Control of Peripheral Nerve Myelination by the ß-Secretase BACE1
Abstract
Although BACE1 (beta-site amyloid precursor protein-cleaving enzyme 1) is essential for the generation of amyloid-b peptide in Alzheimer's disease, its physiological function is unclear. We found that very high levels of BACE1 were expressed at time points when peripheral nerves become myelinated. Deficiency of BACE1 resulted in the accumulation of unprocessed neuregulin 1 (NRG1), an axonally expressed factor required for glial cell development and myelination. BACE1-/- mice displayed hypomyelination of peripheral nerves and aberrant axonal segregation of small-diameter afferent fibers, very similar to that seen in mice with mutations in type III NRG1 or Schwann cell-specific ErbB2 knockouts. Thus, BACE1 is required for myelination and correct bundling of axons by Schwann cells, probably through processing of type III NRG1.
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Besides APP, BACE1 has other substrates that may be important for synaptic plasticity and synaptic homeostasis.
“Besides the amyloidogenic pathway, BACE1 has other substrates that may be important for synaptic plasticity and synaptic homeostasis.”
From The β-Secretase BACE1 in Alzheimer’s Disease (2021) · cites this paper as [70]
Cites
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · see citing works
Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity
Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashler, J. R., Stratman, N. C., Mathews, W. R., Buhl, A. E., et al. (1999) · Nature · doi:10.1038/990107 · Cited by 1,438 · see citing works
Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase
Hussain, I., Powell, D., Howlett, D. R., Tew, D. G., Meek, T. D., Chapman, C., Gloger, I. S., Murphy, K. E., Southan, C. D., Ryan, D. M., et al. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0811 · Cited by 1,080 · see citing works
Luo, Y., Bolon, B., Kahn, S., Bennett, B. D., Babu-Khan, S., Denis, P., Fan, W., Kha, H., Zhang, J., Gong, Y., et al. (2001) · Nature Neuroscience · doi:10.1038/85059 · Cited by 1,001 · see citing works
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
Şahin, U., Weskamp, G., Kelly, K., Zhou, H., Higashiyama, S., Peschon, J. J., Hartmann, D., Säftig, P., & Blobel, C. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200307137 · Cited by 979 · see citing works
Axonal Neuregulin-1 Regulates Myelin Sheath Thickness
Michailov, G. V., Sereda, M. W., Brinkmann, B. G., Fischer, T. M., Haug, B., Birchmeier, C., Role, L. W., Lai, C., Schwab, M. H., & Nave, K. (2004) · Science · doi:10.1126/science.1095862 · Cited by 940 · see citing works
BACE1 is the major β-secretase for generation of Aβ peptides by neurons
Cai, H., Wang, Y.-S., McCarthy, D., Wen, H., Borchelt, D., Price, D. L., & Wong, P. (2001) · Nature Neuroscience · doi:10.1038/85064 · Cited by 791 · see citing works
Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein
Lin, X., Koelsch, G., Wu, S., Downs, D., Dashti, A., & Tang, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1456 · Cited by 769 · see citing works
Neuregulin-1 Type III Determines the Ensheathment Fate of Axons
Taveggia, C., Zanazzi, G. J., Petrylak, A., Yano, H., D, J. R. M., Einheber, S., Xu, X., Esper, R. M., Loeb, J. A., Shrager, P. G., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.017 · Cited by 730 · see citing works
Roberds, S. L. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.12.1317 · Cited by 705 · see citing works
Take five—BACE and the γ‐secretase quartet conduct Alzheimer's amyloid β‐peptide generation
Haass, C. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600061 · Cited by 547 · see citing works
Laird, F. M., Cai, H., Savonenko, A. V., Farah, M. H., He, K., Melnikova, T., Wen, H., Chiang, H.-C., Xu, G., Koliatsos, V. E., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2766-05.2005 · Cited by 521 · see citing works
Cellular mechanisms of β-amyloid production and secretion
Sinha, S., & Lieberburg, I. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11049 · Cited by 438 · see citing works
Farzan, M., Schnitzler, C. E., Vasilieva, N. Y., Leung, D. G., & Choe, H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160115697 · Cited by 409 · see citing works
Binding specificities and affinities of egf domains for ErbB receptors
Jones, J. T., Akita, R. W., & Sliwkowski, M. X. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00283-5 · Cited by 387 · see citing works
BACE1: The β-Secretase Enzyme in Alzheimer's Disease
Vassar, R. J. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:23:1-2:105 · Cited by 369 · see citing works
Phenotypic and Biochemical Analyses of BACE1- and BACE2-deficient Mice
Dominguez, D. I., Tournoy, J., Hartmann, D., Huth, T., Cryns, K., Deforce, S., Serneels, L., Espuny-Camacho, I., Marjaux, E., Craessaerts, K., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505249200 · Cited by 359 · see citing works
Wong, H. K., Sakurai, T., Oyama, F., Kaneko, K., Wada, K., Miyazaki, H., Kurosawa, M., Strooper, B. D., Säftig, P., & Nukina, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414648200 · Cited by 290 · see citing works
Stachel, S. J., Coburn, C. A., Steele, T. G., Jones, K. G., Loutzenhiser, E. F., Gregro, A. R., Rajapakse, H. A., Lai, M., Crouthamel, M., Xu, M., et al. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm049379g · Cited by 278 · see citing works
Kitazume, S., Tachida, Y., Oka, R., Shirotani, K., Saido, T. C., & Hashimoto, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241509198 · Cited by 277 · see citing works
A Dual Role oferbB2in Myelination and in Expansion of the Schwann Cell Precursor Pool
Garratt, A. N., Voiculescu, O., Topilko, P., Charnay, P., & Birchmeier, C. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.5.1035 · Cited by 264 · see citing works
Lichtenthaler, S. F., Dominguez, D.-I., Westmeyer, G. G., Reiß, K., Haass, C., Säftig, P., Strooper, B. D., & Seed, B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303861200 · Cited by 256 · see citing works
Cleavage of Amyloid-β Precursor Protein and Amyloid-β Precursor-like Protein by BACE 1
Li, Q., & Südhof, T. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310001200 · Cited by 219 · see citing works
β-Secretase inhibition for the treatment of Alzheimer's disease – promise and challenge
Citron, M. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2003.12.004 · Cited by 194 · see citing works
BACE2 Functions as an Alternative α-Secretase in Cells
Yan, R., Munzner, J. B., Shuck, M. E., & Bienkowski, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105583200 · Cited by 183 · see citing works
Horiuchi, K., Zhou, H., Kelly, K., Manova, K., & Blobel, C. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.05.004 · Cited by 163 · see citing works
Montero, J. C., Yuste, L., Dı́az-Rodrı́guez, E., Esparı́s-Ogando, A., & Pandiella, A. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0896 · Cited by 162 · see citing works
ASP1 (BACE2) Cleaves the Amyloid Precursor Protein at the β-Secretase Site
Hussain, I., Powell, D. J., Howlett, D. R., Chapman, G. A., Gilmour, L., Murdock, P. R., Tew, D. G., Meek, T. D., Chapman, C. G., Schneider, K., et al. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0884 · Cited by 156 · see citing works
Current progress in beta-amyloid immunotherapy
Schenk, D., Hagen, M., & Seubert, P. A. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.07.012 · Cited by 134 · see citing works
Wang, J. Y., Miller, S. J., & Falls, D. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005700200 · Cited by 126 · see citing works
Neuregulins and the neuromuscular system: 10 years of answers and questions
Falls, D. L. (2003) · Journal of Neurocytology · doi:10.1023/b:neur.0000020614.83883.be · Cited by 120 · see citing works
Characterization of α2,6-Sialyltransferase Cleavage by Alzheimer's β-Secretase (BACE1)
Kitazume, S., Tachida, Y., Oka, R., Kotani, N., Ogawa, K., Suzuki, M., Dohmae, N., Takio, K., Saido, T. C., & Hashimoto, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206262200 · Cited by 109 · see citing works
Li, L., Cleary, S., Mandarano, M. A., Long, W., Birchmeier, C., & Jones, F. E. (2002) · Oncogene · doi:10.1038/sj.onc.1205634 · Cited by 95 · see citing works
Fluhrer, R., Multhaup, G., Schlicksupp, A., Okochi, M., Takeda, M., Lammich, S., Willem, M., Westmeyer, G. G., Bode, W., Walter, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211485200 · Cited by 81 · see citing works
Shi, X.-P., Tugusheva, K., Bruce, J. E., Lucka, A., Wu, G.-X., Chen-Dodson, E., Price, E. A., Li, Y., Xu, M., Huang, Q., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209859200 · Cited by 74 · see citing works
Lemke, G. (2006) · Science s STKE · doi:10.1126/stke.3252006pe11 · Cited by 74 · see citing works
Montero, J. C., Yuste, L., Dı́az-Rodrı́guez, E., Esparı́s-Ogando, A., & Pandiella, A. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3630211 · Cited by 67 · see citing works
Presenilins in Memory, Alzheimer's Disease, and Therapy
Marjaux, E., Hartmann, D., & Strooper, B. D. (2004) · Neuron · doi:10.1016/s0896-6273(04)00218-1 · Cited by 63 · see citing works
Closing the gaps among a web of DNA repair disorders
Michelson, R. J., & Weinert, T. A. (2000) · BioEssays · doi:10.1002/1521-1878(200011)22:11 · Cited by 61 · see citing works
Montero, J. C., Yuste, L., Dı́az-Rodrı́guez, E., et al. (2002) · Biochemical Journal · doi:10.1042/bj3630211 · Cited by 46 · see citing works
Vandermeeren, M., Geraerts, M., Pype, S., Dillen, L., Hove, C. V., & Mercken, M. H. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02369-2 · Cited by 39 · see citing works
ErbB‐4 and neuregulin expression in the adult mouse olfactory bulb after peripheral denervation
Oberto, M., Soncin, I., Bovolin, P., Voyron, S., Bortoli, M. D., Dati, C., Fasolo, A., & Perroteau, I. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01667.x · Cited by 19 · see citing works
Molecular mechanisms for neurodegeneration
Lashuel, H. A. (2013) · Bulletin of the American Physical Society · Cited by 4 · see citing works
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The amyloid hypothesis of Alzheimer's disease at 25 years
Selkoe, D. J., & Hardy, J. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606210 · Cited by 6,164 · see citing works
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744 · see citing works
Self-citationAlzheimer Disease: An Update on Pathobiology and Treatment Strategies
Long, J. M., & Holtzman, D. M. (2019) · Cell · doi:10.1016/j.cell.2019.09.001 · Cited by 3,204 · see citing works
Amyloid Precursor Protein Processing and Alzheimer's Disease
O'Brien, R. J., & Wong, P. C. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113613 · Cited by 2,061 · see citing works
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., Cedazo-Minguez, A., Dubois, B., Edvardsson, D., Feldman, H., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00062-4 · Cited by 1,676 · see citing works
Alzheimer’s Disease: The Challenge of the Second Century
Holtzman, D. M., Morris, J. C., & Goate, A. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002369 · Cited by 1,424 · see citing works
Faghihi, M. A., Modarresi, F., Khalil, A. M., Wood, D. E., Sahagan, B. G., Morgan, T. E., Finch, C. E., St. Laurent III, G., Kenny, P. J., & Wahlestedt, C. (2008) · Nature Medicine · doi:10.1038/nm1784 · Cited by 1,416 · see citing works
Hébert, S. S., Horré, K., Nicolaï, L., Papadopoulou, A. S., Mandemakers, W., Silahtaroglu, A. N., Kauppinen, S., Delacourte, A., & De Strooper, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710263105 · Cited by 1,183 · see citing works
Trafficking and Proteolytic Processing of APP
Haass, C., Kaether, C., Thinakaran, G., & Sisodia, S. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006270 · Cited by 1,075 · see citing works
Alzheimer's disease: strategies for disease modification
Citron, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2896 · Cited by 1,060 · see citing works
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia
Mei, L., & Xiong, W.-C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2392 · Cited by 1,030 · see citing works
Myelination of the Nervous System: Mechanisms and Functions
Nave, K., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 1,000 · see citing works
APP processing in Alzheimer’s disease.
Zhang, Y.-W., Thompson, R., Zhang, H., & Xu, H. (2011) · Molecular Brain · doi:10.1186/1756-6606-4-3 · Cited by 983 · see citing works
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
Kleinberger, G., Yamanishi, Y., Suárez-Calvet, M., Czirr, E., Lohmann, E., Cuyvers, E., Struyfs, H., Pettkus, N., Wenninger-Weinzierl, A., Mazaheri, F., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009093 · Cited by 798 · see citing works
Self-citationAdvances in peripheral nerve regeneration
Scheib, J. L., & Höke, A. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.227 · Cited by 752 · see citing works
The epidermal growth factor receptor family: Biology driving targeted therapeutics
Wieduwilt, M. J., & Moasser, M. M. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7440-8 · Cited by 757 · see citing works
The secretases: enzymes with therapeutic potential in Alzheimer disease
De Strooper, B., Vassar, R., & Golde, T. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.218 · Cited by 799 · see citing works
The β-Secretase BACE1 in Alzheimer’s Disease
Hampel, H., Vassar, R., De Strooper, B., Hardy, J., Willem, M., Singh, N., Zhou, J., Yan, R., Vanmechelen, E., De Vos, A., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.001 · Cited by 694 · see citing works
An overview of APP processing enzymes and products.
Chow, V. W., Mattson, M. P., Wong, P. C., & Gleichmann, M. (2010) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8104-z · Cited by 684 · see citing works
Animal models of Alzheimer's disease and frontotemporal dementia
Götz, J., & Ittner, L. M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2420 · Cited by 676 · see citing works
Axon-Glial Signaling and the Glial Support of Axon Function
Nave, K., & Trapp, B. D. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094309 · Cited by 659 · see citing works
Targeting the β secretase BACE1 for Alzheimer’s disease therapy
Yan, R., & Vassar, R. (2014) · Lancet Neurology · doi:10.1016/s1474-4422(13)70276-x · Cited by 550 · see citing works
Alzheimer's Disease: From Pathology to Therapeutic Approaches
Jakob‐Roetne, R., & Jacobsen, H. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200802808 · Cited by 626 · see citing works
Kuhn, P., Wang, H., Dislich, B., Colombo, A., Zeitschel, U., Ellwart, J. W., Kremmer, E., Roßner, S., & Lichtenthaler, S. F. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.167 · Cited by 621 · see citing works
Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases
Mei, L., & Nave, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.007 · Cited by 590 · see citing works
The Alzheimer's disease Beta-secretase enzyme, BACE1
Cole, S. L., & Vassar, R. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-22 · Cited by 550 · see citing works
Alzheimer's disease as homeostatic responses to age-related myelin breakdown
Bartzokis, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.007 · Cited by 546 · see citing works
Evidence for natural antisense transcript-mediated inhibition of microRNA function
Faghihi, M., Zhang, M., Huang, J., Modarresi, F., van der Brug, M. P., Nalls, M., Cookson, M., Laurent, G. S. S., & Wahlestedt, C. (2010) · Genome Biology · doi:10.1186/gb-2010-11-5-r56 · Cited by 525 · see citing works
Vassar, R., Kovacs, D. M., Yan, R., & Wong, P. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3657-09.2009 · Cited by 577 · see citing works
Negative regulation of myelination: Relevance for development, injury, and demyelinating disease
Jessen, K. R., & Mirsky, R. (2008) · Glia · doi:10.1002/glia.20761 · Cited by 515 · see citing works
Wallerian degeneration: the innate-immune response to traumatic nerve injury
Rotshenker, S. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-109 · Cited by 511 · see citing works
Presenilins and -Secretase: Structure, Function, and Role in Alzheimer DiseasePreprint
Strooper, B. D., Iwatsubo, T., & Wolfe, M. S. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006304 · Cited by 465 · see citing works
Therapeutic strategies for Alzheimer's disease in clinical trials
Godyń, J., Jończyk, J., Panek, D., & Malawska, B. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.07.006 · Cited by 454 · see citing works
Kent, S. A., Spires-Jones, T. L., & Durrant, C. S. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02196-w · Cited by 446 · see citing works
Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes
Ly, P. T. T., Wu, Y., Zou, H., Wang, R., Zhou, W., Kinoshita, A., Zhang, M., Yang, Y., Cai, F., Woodgett, J., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64516 · Cited by 442 · see citing works
Animal Models of Alzheimer Disease
LaFerla, F. M., & Green, K. N. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006320 · Cited by 419 · see citing works
The role of astrocytes in amyloid production and Alzheimer's disease
Frost, G. R., & Li, Y. (2017) · Open Biology · doi:10.1098/rsob.170228 · Cited by 435 · see citing works
Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury
Nocera, G., & Jacob, C. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03516-9 · Cited by 450 · see citing works
Kennedy, M., Stamford, A., Chen, X., Cox, K., Cumming, J., Dockendorf, M., Egan, M. F., Ereshefsky, L., Hodgson, R., Hyde, L., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad9704 · Cited by 391 · see citing works
O’Connor, T., Sadleir, K. R., Maus, E., Velliquette, R. A., Zhao, J., Cole, S. L., Eimer, W. A., Hitt, B. D., Bembinster, L. A., Lammich, S., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.047 · Cited by 422 · see citing works
Brinkmann, B. G., Agarwal, A., Sereda, M. W., Garratt, A. N., Müller, T. H., Wende, H., Stassart, R. M., Nawaz, S., Humml, C., Velanac, V., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.028 · Cited by 419 · see citing works
BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease
Vassar, R. (2014) · Alzheimer's Research & Therapy · doi:10.1186/s13195-014-0089-7 · Cited by 393 · see citing works
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
De Strooper, B. (2010) · Physiological Reviews · doi:10.1152/physrev.00023.2009 · Cited by 455 · see citing works
Natural products as a source of Alzheimer's drug leads
Williams, P., Sorribas, A., & Howes, M.-J. R. (2011) · Nat. Prod. Rep. · doi:10.1039/c0np00027b · Cited by 404 · see citing works
Axonal prion protein is required for peripheral myelin maintenance
Bremer, J., Baumann, F., Tiberi, C., Wessig, C., Fischer, H., Schwarz, P., Steele, A. D., Toyka, K. V., Nave, K., Weis, J., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2483 · Cited by 395 · see citing works
The EGF receptor family: spearheading a merger of signaling and therapeutics
Bublil, E. M., & Yarden, Y. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.008 · Cited by 398 · see citing works
May, P. C., Dean, R. A., Lowe, S. L., Martényi, F., Sheehan, S. M., Boggs, L. N., Monk, S. A., Mathes, B. M., Mergott, D. J., Watson, B. M., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3647-11.2011 · Cited by 373 · see citing works
Schwann Cell MyelinationPreprint
Salzer, J. L. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020529 · Cited by 365 · see citing works
MicroRNAs in Common Human Diseases
Li, Y., & Kowdley, K. V. (2012) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2012.07.005 · Cited by 360 · see citing works
BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease
Ghosh, A. K., & Osswald, H. L. (2014) · Chemical Society Reviews · doi:10.1039/c3cs60460h · Cited by 361 · see citing works
In search of partners: linking extracellular proteases to substrates
Overall, C. M., & Blobel, C. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2120 · Cited by 350 · see citing works
Biology and pathophysiology of the amyloid precursor protein
Zheng, H., & Koo, E. H. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-27 · Cited by 346 · see citing works
Proteolytic processing of Alzheimer’s β‐amyloid precursor protein
Zhang, H., Ma, Q., Zhang, Y., & Xu, H. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07519.x · Cited by 344 · see citing works
Vassar, R. J., Kuhn, P., Haass, C., Kennedy, M. E., Rajendran, L., Wong, P. C., & Lichtenthaler, S. F. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12715 · Cited by 329 · see citing works
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
Kuhn, P., Koroniak–Szejn, K., Hogl, S., Colombo, A. V., Zeitschel, U., Willem, M., Volbracht, C., Schepers, U., Imhof, A., Hoffmeister, A., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.173 · Cited by 318 · see citing works
Moloney, E. B., de Winter, F., & Verhaagen, J. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00252 · Cited by 308 · see citing works
Lichtenthaler, S. F., Lemberg, M. K., & Fluhrer, R. (2018) · The EMBO Journal · doi:10.15252/embj.201899456 · Cited by 298 · see citing works
BACE1 regulates voltage-gated sodium channels and neuronal activity
Kim, D. Y., Carey, B. W., Wang, H., Ingano, L. A. M., Binshtok, A. M., Wertz, M. H., Pettingell, W. H., He, P., Lee, V. M. ‐., Woolf, C. J., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1602 · Cited by 301 · see citing works
BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice
Ohno, M., Cole, S. L., Yasvoina, M., Zhao, J., Citron, M., Berry, R., Disterhoft, J. F., & Vassar, R. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.008 · Cited by 290 · see citing works
Savonenko, A. V., Melnikova, T., Laird, F. M., Stewart, K.-A., Price, D. L., & Wong, P. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710373105 · Cited by 290 · see citing works
Signals to promote myelin formation and repair
Taveggia, C., Feltri, M. L., & Wrabetz, L. G. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.37 · Cited by 281 · see citing works
Membrane rafts in Alzheimer's disease beta-amyloid production
Vetrivel, K. S., & Thinakaran, G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.03.007 · Cited by 283 · see citing works
Selected organophosphorus compounds with biological activity. Applications in medicine
Demkowicz, S., Rachoń, J., Daśko, M., & Kozak, W. (2016) · RSC Advances · doi:10.1039/c5ra25446a · Cited by 282 · see citing works
Fernández‐Bachiller, M. I., Pérez, C., Monjas, L., Rademann, J., & Rodrı́guez-Franco, M. I. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm201460y · Cited by 271 · see citing works
Nrg1/ErbB signaling networks in Schwann cell development and myelination
Newbern, J. M., & Birchmeier, C. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.08.008 · Cited by 266 · see citing works
Cole, S. L., & Vassar, R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800015200 · Cited by 262 · see citing works
The Transcription Factor Yin Yang 1 Is Essential for Oligodendrocyte Progenitor Differentiation
He, Y., Dupree, J. L., Wang, J., Sandoval, J., Li, J., Liu, H., Shi, Y., Nave, K. A., & Casaccia‐Bonnefil, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.029 · Cited by 263 · see citing works
Cognitive impairment and vitamin B12: a review
Moore, E. M., Mander, A. G., Ames, D. J., Carne, R. P., Sanders, K. M., & Watters, D. A. (2012) · International Psychogeriatrics · doi:10.1017/s1041610211002511 · Cited by 265 · see citing works
McConlogue, L., Buttini, M., Anderson, J. P., Brigham, E. F., Chen, K. S., Freedman, S. B., Games, D., Johnson-Wood, K., Lee, M., Zeller, M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611687200 · Cited by 300 · see citing works
New insights on schwann cell development
Monk, K. R., Feltri, M. L., & Taveggia, C. (2015) · Glia · doi:10.1002/glia.22852 · Cited by 256 · see citing works
Neuregulin‐1, a key axonal signal that drives Schwann cell growth and differentiation
Birchmeier, C., & Nave, K. (2008) · Glia · doi:10.1002/glia.20753 · Cited by 254 · see citing works
Molecular mechanisms regulating myelination in the peripheral nervous system
Pereira, J. A., Lebrun-Julien, F., & Suter, U. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.006 · Cited by 253 · see citing works
Kandalepas, P. C., Sadleir, K. R., Eimer, W. A., Zhao, J., Nicholson, D. A., & Vassar, R. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1152-3 · Cited by 240 · see citing works
Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing
Lichtenthaler, S. F., Haass, C., & Steiner, H. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07248.x · Cited by 230 · see citing works
Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors
Tayeb, H. O., Yang, H. D., Price, B. H., & Tarazi, F. I. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.12.002 · Cited by 231 · see citing works
Sutinen, E. M., Pirttilä, T., Anderson, G., Salminen, A., & Ojala, J. O. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-199 · Cited by 228 · see citing works
Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation
Mirsky, R., Woodhoo, A., Parkinson, D. B., Arthur‐Farraj, P., Bhaskaran, A., & Jessen, K. R. (2008) · Journal of the Peripheral Nervous System · doi:10.1111/j.1529-8027.2008.00168.x · Cited by 229 · see citing works
Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level
Sadleir, K. R., Eimer, W. A., Cole, S. L., & Vassar, R. (2015) · Molecular Neurodegeneration · doi:10.1186/1750-1326-10-1 · Cited by 213 · see citing works
May, P. C., Willis, B. A., Lowe, S. L., Dean, R. A., Monk, S. A., Cocke, P. J., Audia, J. E., Boggs, L. N., Borders, A. R., Brier, R. A., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4129-14.2015 · Cited by 206 · see citing works
Agis-Torres, A., Sollhuber, M., Fernandez, M., & Sanchez-Montero, J. M. (2014) · Current Neuropharmacology · doi:10.2174/1570159x113116660047 · Cited by 202 · see citing works
Alzheimer’s disease: the lipid connection
Hartmann, T., Kuchenbecker, J., & Grimm, M. O. W. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04715.x · Cited by 199 · see citing works
Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics
Hemming, M. L., Elias, J. E., Gygi, S. P., & Selkoe, D. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008477 · Cited by 193 · see citing works
Type III neuregulin‐1 promotes oligodendrocyte myelination
Taveggia, C., Thaker, P., Petrylak, A., Caporaso, G. L., Toews, A. D., Falls, D. L., Einheber, S., & Salzer, J. L. (2007) · Glia · doi:10.1002/glia.20612 · Cited by 193 · see citing works
Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation
Obregon, D., Hou, H., Deng, J., Giunta, B., Tian, J., Darlington, D., Shahaduzzaman, M., Zhu, Y., Mori, T., Mattson, M. P., et al. (2012) · Nature Communications · doi:10.1038/ncomms1781 · Cited by 192 · see citing works
Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves
Hu, X., He, W.-X., Diaconu, C., Tang, X., Kidd, G., Macklin, W., Trapp, B. D., & Yan, R. (2008) · The FASEB Journal · doi:10.1096/fj.08-106666 · Cited by 199 · see citing works
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
Xiang, X., Werner, G., Bohrmann, B., Liesz, A., Mazaheri, F., Capell, A., Feederle, R., Knuesel, I., Kleinberger, G., & Haass, C. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606370 · Cited by 183 · see citing works
Self-citationMori, T., Koyama, N., Guillot‐Sestier, M., Tan, J., & Town, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055774 · Cited by 189 · see citing works
Flavonoids as Therapeutic Compounds Targeting Key Proteins Involved in Alzheimer’s Disease
Baptista, F. I., Henriques, A. G., Silva, A. M. S., Wiltfang, J., & Silva, O. A. B. D. C. E. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400213r · Cited by 189 · see citing works
Successful therapies for Alzheimer’s disease: why so many in animal models and none in humans?
Franco, R., & Cedazo-Minguez, A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00146 · Cited by 183 · see citing works
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
Kizuka, Y., Kitazume, S., Fujinawa, R., Saito, T., Iwata, N., Saido, T. C., Nakano, M., Yamaguchi, Y., Hashimoto, Y., Staufenbiel, M., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404438 · Cited by 187 · see citing works
β-Secretase as a Therapeutic Target for Alzheimer’s Disease
Ghosh, A., Gemma, S., & Tang, J. J. N. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2008.05.007 · Cited by 175 · see citing works
BACE1 activity is modulated by cell-associated sphingosine-1-phosphate
Takasugi, N., Sasaki, T., Suzuki, K., Osawa, S., Isshiki, H., Hori, Y., Shimada, N., Higo, T., Yokoshima, S., Fukuyama, T., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6467-10.2011 · Cited by 181 · see citing works
The Neural Cell Adhesion Molecules L1 and CHL1 Are Cleaved by BACE1 Protease in Vivo*
Zhou, L., Barão, S., Laga, M., Bockstael, K., Borgers, M., Gijsen, H., Annaert, W., Moechars, D., Mercken, M., Gevaer, K., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.377465 · Cited by 172 · see citing works
The BACE‐1 inhibitor CNP520 for prevention trials in Alzheimer's disease
Neumann, U., Ufer, M., Jacobson, L. H., Rouzade‐Dominguez, M., Huledal, G., Kolly, C., Lüönd, R. M., Machauer, R., Veenstra, S. J., Hurth, K., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809316 · Cited by 177 · see citing works
Scott, J. D., Li, S. W., Brunskill, A., Chen, X., Cox, K., Cumming, J., Forman, M., Gilbert, E., Hodgson, R., Hyde, L., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00307 · Cited by 137 · see citing works
Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves
Jessen, K. R., & Mirsky, R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00069 · Cited by 173 · see citing works
Induction of Abnormal Proliferation by Nonmyelinating Schwann Cells Triggers Neurofibroma Formation
Zheng, H., Chang, L., Patel, N. U., Yang, J., Lowe, L., Burns, D. K., & Zhu, Y. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.002 · Cited by 170 · see citing works
Signals regulating myelination in peripheral nerves and the Schwann cell response to injury
Glenn, T. D., & Talbot, W. S. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.06.010 · Cited by 171 · see citing works
γ-secretases: from cell biology to therapeutic strategies
Bergmans, B. A., & Strooper, B. D. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70332-1 · Cited by 172 · see citing works
Calvo, M., Zhu, N., Tsantoulas, C., Ma, Z., Grist, J., Loeb, J. A., & Bennett, D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5169-09.2010 · Cited by 166 · see citing works
- Authors
- Willem, M., Garratt, A. N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., DeStrooper, B., Saftig, P., Birchmeier, C., & Haass, C.
- Affiliations
- Amgen (United States) (US)
- Adolf Butenandt-Institute, Department of Biochemistry, Laboratory for Alzheimer's and Parkinson's Disease Research, Schillerstrasse 44, Ludwig-Maximilians-University, 80336 Munich, Germany.
- Corresponding author
- Garratt, Alistair N.
- Haass, Christian
- Venue
- Science
- Published
- 2006-10-27
- Volume
- 314
- Issue
- 5799
- Pages
- 664-666
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1977688919
- Cited by
- 703
- References
- 43
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 13 · 2023: 14 · 2022: 16 · 2021: 26 · 2020: 29 · 2019: 29 · 2018: 31 · 2017: 35 · 2016: 50 · 2015: 39 · 2014: 47 · 2013: 52 · 2012: 55
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Lirias (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- BACE1, peripheral nerve myelination, neuregulin-1, Schwann cells, hypomyelination, axon bundling, afferent nerve fibers, ERBB2, amyloid precursor protein
- MeSH terms
- Alzheimer Disease, Animals, Axons, Ganglia, Spinal, Motor Neurons, Myelin Sheath, Nerve Tissue Proteins, Neurons, Afferent, Endopeptidases, Protein Processing, Post-Translational, Schwann Cells, Sciatic Nerve, Spinal Cord, Aspartic Acid Endopeptidases, Mice, Knockout, Protein Isoforms, Neuregulin-1, Mice, Amyloid Precursor Protein Secretases
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