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Cited by 29Pancreatitis Pathology and TreatmentLipid metabolism and disordersPregnancy and Medication Impact

Severe hypertriglyceridemia and acute pancreatitis during pregnancy: treatment with gemfibrozil.

Saadi, Hussein F., Kurlander, Donald J., Erkins, Johnny M., Hoogwerf, Byron J.·1999·Endocrine Practice
DOI 10.4158/ep.5.1.33
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Abstract

Objective To describe the effect of gemfibrozil therapy during pregnancy in a woman with severe hypertriglyceridemia.Methods We present a case report, with details of lipid levels throughout several attempted pregnancies, and discuss other similar published studies.Results In a 22-year-old woman, severe acute pancreatitis due to hypertriglyceridemia developed during her first pregnancy. After a prolonged hospital course, the outcome was fetal demise. The patient was subsequently treated with gemfibrozil, which controlled the hypertriglyceridemia. A second pregnancy ended with a therapeutic abortion at 1 month because of the possible risk of pancreatitis. Gemfibrozil therapy was instituted but subsequently discontinued when she was discovered to be pregnant again, at approximately 10 weeks of gestation; the potential risks involved with the use of this drug during pregnancy were unknown. Because of the patient's strong desire to maintain the pregnancy, gemfibrozil treatment was resumed 1 week later in order to help prevent recurrent pancreatitis. The patient ultimately delivered a fullterm healthy boy, and she had no recurrence of pancreatitis or other complications.Conclusion In selected patients at high risk for pancreatitis, the potential risk of gemfibrozil use during pregnancy may be offset by its benefits in the management of severe hypertriglyceridemia.

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  • In women with underlying disorders of triglyceride metabolism or overproduction, an estrogen-induced increase in triglycerides during pregnancy can result in risk of pancreatitis with potential fetal loss.

    “In women with underlying disorders of triglyceride metabolism or overproduction, an estrogeninduced increase in triglycerides during pregnancy can result in a risk of pancreatitis with potential fetal loss (85, 86).”

    From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [86]

  • Gemfibrozil can be considered in very severe hypertriglyceridemia beginning in the second trimester in pregnant women who are at risk of pancreatitis.

    “Gemfibrozil can be considered in very severe hypertriglyceridemia beginning in the second trimester in pregnant women who are at risk of pancreatitis (86).”

    From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [86]

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Authors
Saadi, H. F., Kurlander, D. J., Erkins, J. M., & Hoogwerf, B. J.
Affiliations
  • Cleveland Clinic (US)
  • Mount Sinai Hospital (US)
Corresponding author
Saadi, Hussein F.
ORCID
Venue
Endocrine Practice
Publisher
Elsevier BV
Published
1999-01
Volume
5
Issue
1
Pages
33-36
ISSN
1530-891X (ISSN-L)
DOI
10.4158/ep.5.1.33
OpenAlex
W2131195795
Cited by
29
References
22
Citations by year
2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 2 · 2018: 3 · 2017: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Endocrine Practice (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords
gemfibrozil, severe hypertriglyceridemia, acute pancreatitis, pregnancy, drug safety in pregnancy, fetal death, therapeutic abortion, lipid-lowering therapy

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