The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Functions of autophagy in normal and diseased liver
Open accessAbstract
Autophagy has emerged as a critical lysosomal pathway that maintains cell function and survival through the degradation of cellular components such as organelles and proteins. Investigations specifically employing the liver or hepatocytes as experimental models have contributed significantly to our current knowledge of autophagic regulation and function. The diverse cellular functions of autophagy, along with unique features of the liver and its principal cell type the hepatocyte, suggest that the liver is highly dependent on autophagy for both normal function and to prevent the development of disease states. However, instances have also been identified in which autophagy promotes pathological changes such as the development of hepatic fibrosis. Considerable evidence has accumulated that alterations in autophagy are an underlying mechanism of a number of common hepatic diseases including toxin-, drug- and ischemia/reperfusion-induced liver injury, fatty liver, viral hepatitis and hepatocellular carcinoma. This review summarizes recent advances in understanding the roles that autophagy plays in normal hepatic physiology and pathophysiology with the intent of furthering the development of autophagy-based therapies for human liver diseases.
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Citations
Cites
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Cellular and molecular mechanisms of fibrosis
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
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Autophagy regulates lipid metabolism
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Self-citationTFEB Links Autophagy to Lysosomal Biogenesis
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Cited by
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Self-citationBile acid signaling in metabolic disease and drug therapy
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Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy
Chiang, J. Y. L., & Ferrell, J. M. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00223.2019 · Cited by 580
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Autophagy in liver diseases: Time for translation?
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Metadata
- Authors
- Czaja, M. J., Ding, W.-X., Donohue, T. M., Friedman, S. L., Kim, J.-S., Komatsu, M., Lemasters, J. J., Lemoine, A., Lin, J. D., Ou, J.-H. J., Perlmutter, D. H., Randall, G., Ray, R. B., Tsung, A., & Yin, X.-M.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2013-08-14
- Volume
- 9
- Issue
- 8
- Pages
- 1131-1158
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W2111754392
- Cited by
- 436
- References
- 58
- FWCI
- 23.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Czaja, M. J., Ding, W.-X., Donohue, T. M., Friedman, S. L., Kim, J.-S., Komatsu, M., Lemasters, J. J., Lemoine, A., Lin, J. D., Ou, J.-H. J., Perlmutter, D. H., Randall, G., Ray, R. B., Tsung, A., & Yin, X.-M. (2013). Functions of autophagy in normal and diseased liver. Autophagy. https://doi.org/10.4161/auto.25063
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