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Cited by 167

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AMPK Mediates Autophagy during Myocardial Ischemia In Vivo

Open access
Takagi, Hiromitsu, Matsui, Yutaka, Hirotani, Shinichi, Sakoda, Hideyuki, Asano, Tomoichiro, Sadoshima, Junichi·2007·Autophagy
DOI 10.4161/auto.4281
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Abstract

We have recently shown that autophagy is induced by ischemia and reperfusion in the mouse heart in vivo. Ischemia stimulates autophagy through an AMP activated protein kinase (AMPK)-dependent mechanism, whereas reperfusion after ischemia stimulates autophagy through a Beclin 1-dependent, but AMPK-independent, mechanism. Autophagy plays distinct roles during ischemia and reperfusion: autophagy may be protective during ischemia, whereas it may be detrimental during reperfusion. We will discuss the role of AMPK in mediating autophagy during myocardial ischemia in vivo.Addendum to:Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating AutophagyY. Matsui, H. Takagi, X. Qu, M. Abdellatif, H. Sakoda, T. Asano, B. Levine and J. SadoshimaCirc Res 2007; 100:914-22

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Metadata

Authors
Takagi, H., Matsui, Y., Hirotani, S., Sakoda, H., Asano, T., & Sadoshima, J.
Venue
Autophagy
Publisher
Informa UK Limited
Published
2007-07-16
Volume
3
Issue
4
Pages
405-407
ISSN
  • 1554-8627 (ISSN-L)
  • 1554-8635
DOI
10.4161/auto.4281
OpenAlex
W2041538521
Cited by
167
References
0
FWCI
4.61
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: AMPK Mediates Autophagy during Myocardial Ischemia In Vivo. https://app.cochat.ai/papers/10.4161/auto.4281
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Takagi, H., Matsui, Y., Hirotani, S., Sakoda, H., Asano, T., & Sadoshima, J. (2007). AMPK Mediates Autophagy during Myocardial Ischemia In Vivo. Autophagy. https://doi.org/10.4161/auto.4281

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.