The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.
Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease
Open accessAbstract
Autophagy, a vital catabolic process that degrades cytoplasmic components within the lysosome, is an essential cytoprotective response to pathologic stresses that occur during diseases such as cancer, ischemia, and infection. In addition to its role as a stress-response pathway, autophagy plays an essential quality-control function in the cell by promoting basal turnover of long-lived proteins and organelles, as well as by selectively degrading damaged cellular components. This homeostatic function protects against a wide variety of diseases, including neurodegeneration, myopathy, liver disease, and diabetes. This review discusses our current understanding of these two principal functions of autophagy and describes in detail how alterations in autophagy promote human disease.
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Cites
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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Autophagy fights disease through cellular self-digestion
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Cited by
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
Zhang, X., Cheng, X., Yu, L., Yang, J., Calvo, R., Patnaik, S., Hu, X., Gao, Q., Yang, M., Lawas, M., et al. (2016) · Nature Communications · doi:10.1038/ncomms12109 · Cited by 558
The Four Faces of Autophagy: Implications for Cancer Therapy
Gewirtz, D. A. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2966 · Cited by 435
ROS: Crucial Intermediators in the Pathogenesis of Intervertebral Disc Degeneration
Feng, C., Yang, M., Lan, M., Liu, C., Zhang, Y., Huang, B., Liu, H., & Zhou, Y. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5601593 · Cited by 384
Ubiquitin-mediated regulation of autophagy
Chen, R.-H., Chen, Y.-H., & Huang, T.-Y. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0569-y · Cited by 322
The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules
Cruz, F. M., Colbert, J. D., Merino, E., Kriegsman, B. A., & Rock, K. L. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055254 · Cited by 299
Metadata
- Authors
- Murrow, L., & Debnath, J.
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2013-01-24
- Volume
- 8
- Issue
- 1
- Pages
- 105-137
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- OpenAlex
- W2166443964
- Cited by
- 527
- References
- 150
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Murrow, L., & Debnath, J. (2013). Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease. Annual Review of Pathology: Mechanisms of Disease. https://doi.org/10.1146/annurev-pathol-020712-163918
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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