How to Interpret LC3 Immunoblotting

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276

The role of autophagy during the early neonatal starvation period

Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., & Mizushima, N. (2004) · Nature · doi:10.1038/nature03029 · Cited by 2,865

The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

Nakai, A., Yamaguchi, O., Takeda, T., Higuchi, Y., Hikoso, S., Taniike, M., Omiya, S., Mizote, I., Matsumura, Y., Asahi, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1574 · Cited by 1,520

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

Kabeya, Y., Mizushima, N., Yamamoto, A., Oshitani-Okamoto, S., Ohsumi, Y., & Yoshimori, T. (2004) · Journal of Cell Science · doi:10.1242/jcs.01131 · Cited by 1,394

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

Yamamoto, A., Tagawa, Y., Yoshimori, T., Moriyama, Y., Masaki, R., & Tashiro, Y. (1998) · Cell Structure and Function · doi:10.1247/csf.23.33 · Cited by 1,312

Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

Tanida, I., Minematsu-Ikeguchi, N., Ueno, T., & Kominami, E. (2005) · Autophagy · doi:10.4161/auto.1.2.1697 · Cited by 1,108

The pre‐autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

Suzuki, K., Kirisako, T., Kamada, Y., Mizushima, N., Noda, T., & Ohsumi, Y. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.5971 · Cited by 1,060

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

Kanzawa, T., Germano, I. M., Komata, T., Ito, H., Kondo, Y., & Kondo, S. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401359 · Cited by 995

Methods for monitoring autophagy

Mizushima, N. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.02.005 · Cited by 899

Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes

Dolai, S., Takahashi, T., Qin, T., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1852725 · Cited by 32

Ang II Promotes Cardiac Autophagy and Hypertrophy via Orai1/STIM1

Zheng, C., Gao, W., Xie, M., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.622774 · Cited by 32

Melatonin Treatment Improves Renal Fibrosis via miR-4516/SIAH3/PINK1 Axis

Yoon, Y. M., Go, G., Yoon, S., Lim, J. H., Lee, G., Lee, J. H., & Lee, S. H. (2021) · Cells · doi:10.3390/cells10071682 · Cited by 33

Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity

He, T., Wang, Q., Ao, J., Chen, K., Li, X., Zhang, J., & Duan, C. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.112986 · Cited by 32

Exosomes treating osteoarthritis: hope with challenge

Wu, C., He, Y., Yao, Y., Yang, H. S., & Lu, F. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13152 · Cited by 33

Inhibition of autophagy overcomes glucocorticoid resistance in lymphoid malignant cells

Jiang, L., Xu, L., Xie, J., Li, S., Guan, Y., Zhang, Y., Hou, Z., Guo, T., Shu, X., Wang, C., et al. (2015) · Cancer Biology & Therapy · doi:10.1080/15384047.2015.1016658 · Cited by 34

Chapter 16 Assessing Mammalian Autophagy by WIPI‐1/Atg18 Puncta Formation

Proikas‐Cezanne, T., & Pfisterer, S. G. (2009) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(08)03616-1 · Cited by 32

Does autophagy work in synaptic plasticity and memory?

Shehata, M. H., & Inokuchi, K. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0002 · Cited by 33

Enhancement of doxorubicin cytotoxicity of human cancer cells by tyrosine kinase inhibition of insulin receptor and type I IGF receptor

Zeng, X., Zhang, H., Oh, A. S., Zhang, Y., & Yee, D. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1713-x · Cited by 34

A pathway sensor for genome-wide screens of intracellular proteolytic cleavage

Ketteler, R., Sun, Z., Kovacs, K. F., He, W.-W., & Seed, B. (2008) · Genome biology · doi:10.1186/gb-2008-9-4-r64 · Cited by 32

NAD+ depletion by APO866 in combination with radiation in a prostate cancer model, results from an in vitro and in vivo study

Zerp, S. F., Vens, C., Floot, B., Verheij, M., & van Triest, B. (2014) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2013.10.039 · Cited by 32

Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling

Koehler, B. C., Jassowicz, A., Scherr, A., Lorenz, S., Radhakrishnan, P., Kautz, N., Elßner, C., Weiß, J., Jaeger, D., Schneider, M., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1929-y · Cited by 32

Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

Yeo, S. Y., Itahana, Y., Guo, A. K., Han, R., Iwamoto, K., Nguyen, T., Bao, Y., Kleiber, K., Wu, Y., Bay, B., et al. (2016) · eLife · doi:10.7554/elife.07101 · Cited by 32

Modified Panax ginseng extract regulates autophagy by AMPK signaling in A549 human lung cancer cells

Yoo, H., Kim, J. M., Jo, E., Cho, C.-K., Lee, S.-Y., Kang, H. S., Lee, M. G., Yang, P.-Y., & Jang, I. (2017) · Oncology Reports · doi:10.3892/or.2017.5590 · Cited by 32

Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins

Jiménez, C., Ellahioui, Y., Álvarez, R., et al. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.05.047 · Cited by 32

Hypoxia-induced downregulation of autophagy mediator Beclin-1 reduces the susceptibility of malignant intestinal epithelial cells to hypoxia-dependent apoptosis

Yoo, B. H., Wu, X., Derouet, M. F., Haniff, M., Eskelinen, E., & Rosen, K. V. (2009) · Autophagy · doi:10.4161/auto.5.8.10167 · Cited by 32

A new NRF2 activator for the treatment of human metabolic dysfunction-associated fatty liver disease

Hammoutène, A., Laouirem, S., Albuquerque, M., Colnot, N., Brzustowski, A., Valla, D. C., Provost, N., Delerive, P., & Paradis, V. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100845 · Cited by 37

Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury

Yuan, Z.-L., Mo, Y.-Z., Li, D.-L., Xie, L., & Chen, M. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01211-3 · Cited by 35

Mesenchymal Stem Cell-Derived Exosomes as Drug Carriers for Delivering miRNA-29b to Ameliorate Inflammation in Corneal Injury Via Activating Autophagy

Liu, J., Gao, J., Lü, P., Wang, Y., Xing, S., Yan, Y., Han, R., Peng, H. F., & Li, X. (2024) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.65.6.16 · Cited by 32

PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1

Wang, Z., Hu, J. N., Li, G., Qu, L., He, Q., Lou, Y., Song, Q., Ma, D., & Chen, Y. (2014) · Autophagy · doi:10.4161/auto.36439 · Cited by 31

mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging

Takayama, K., Kawakami, Y., Lavasani, M., Mu, X., Cummins, J. H., Yurube, T., Kuroda, R., Kurosaka, M., Fu, F. H., Robbins, P. D., et al. (2016) · Journal of Orthopaedic Research® · doi:10.1002/jor.23409 · Cited by 31

Methyl Helicterate Inhibits Hepatic Stellate Cell Activation Through Modulation of Apoptosis and Autophagy

Zhang, X., Chen, Z.-N., Huang, Q., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495390 · Cited by 31

Angiotensin II suppresses autophagy and disrupts ultrastructural morphology and function of mitochondria in mouse skeletal muscle

Silva, K. A. S., Ghiarone, T., Schreiber, K. L., Grant, D. G., White, T., Frisard, M. I., Sukhanov, S., Chandrasekar, B., Delafontaine, P., & Yoshida, T. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00898.2018 · Cited by 32

Identification of the autophagy pathway in a mollusk bivalve, Crassostrea gigas

Picot, S., Faury, N., Arzul, I., Chollet, B., Renault, T., & Morga, B. (2020) · Autophagy · doi:10.1080/15548627.2020.1713643 · Cited by 27

Harnessing Autophagic Network Is Essential for Trophoblast Stem Cell Differentiation

Chakraborty, S., Bose, R., Islam, S., Das, S., & Ain, R. (2020) · Stem Cells and Development · doi:10.1089/scd.2019.0296 · Cited by 31

Autophagy inhibition enhances the inhibitory�effects of ursolic acid on lung cancer cells

Wang, M., Yu, H., Wu, R., Chen, Z., Hu, Q., Zhang, Y., Gao, S., & Zhou, G. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4714 · Cited by 31

Maladaptive Autophagy in the Pathogenesis of Autoimmune Epithelitis in Sjögren's Syndrome

Colafrancesco, S., Barbati, C., Priori, R., Putro, E., Giardina, F., Gattamelata, A., Monosi, B., Colasanti, T., Celia, A. I., Cerbelli, B., et al. (2021) · Arthritis & Rheumatology · doi:10.1002/art.42018 · Cited by 31

Phytochemicals Mediate Autophagy Against Osteoarthritis by Maintaining Cartilage Homeostasis

Zheng, T., Zhang, X., & Sun, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.795058 · Cited by 31

Cyclic GMP‐AMP synthase contributes to epithelial homeostasis in intestinal inflammation via Beclin‐1‐mediated autophagy

Khan, S., Mentrup, H. L., Novak, E. A., Siow, V. S., Wang, Q., Crawford, E. C., Schneider, C., Comerford, T. E., Firek, B., Rogers, M. B., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202200138r · Cited by 32

Insulin receptor substrate-1 prevents autophagy-dependent cell death caused by oxidative stress in mouse NIH/3T3 cells

Chan, S. H., Kikkawa, U., Matsuzaki, H., Chen, J.-H., & Chang, W. (2012) · Journal of Biomedical Science · doi:10.1186/1423-0127-19-64 · Cited by 31

Hydroxychloroquine facilitates autophagosome formation but not degradation to suppress the proliferation of cervical cancer SiHa cells

Liu, Q., LUO, X. Y., Jiang, H. X., Yang, M., YUAN, G.-H., Tang, Z., & Wang, H. (2014) · Oncology Letters · doi:10.3892/ol.2014.1879 · Cited by 32

LC3-II Tagging and Western Blotting for Monitoring Autophagic Activity in Mammalian Cells

Streeter, A., Menzies, F. M., & Rubinsztein, D. C. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2627-5_8 · Cited by 31

TNF-α stimulates endothelial palmitic acid transcytosis and promotes insulin resistance

Li, W., Yang, X., Zheng, T., Xing, S., Wu, Y., Bian, F., Wu, G., Li, Y., Li, J., Bai, X., et al. (2017) · Scientific Reports · doi:10.1038/srep44659 · Cited by 33

VCP Machinery Mediates Autophagic Degradation of Empty Argonaute

Kobayashi, H., Shoji, K., Kiyokawa, K., Negishi, L., & Tomari, Y. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.003 · Cited by 32

Light-Controlled Intracellular Synthesis of Poly(luciferin) Polymers Induces Cell Paraptosis

Dai, S., Xiao, Z., Shen, F., et al. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.4c15644 · Cited by 30

Coxsackievirus B3-induced calpain activation facilitates the progeny virus replication via a likely mechanism related with both autophagy enhancement and apoptosis inhibition in the early phase of infection: An in vitro study in H9c2 cells

Li, M., Wang, X., Yu, Y. Q., Yu, Y., Xie, Y., Zou, Y., Ge, J., Peng, T., & Chen, R. (2013) · Virus Research · doi:10.1016/j.virusres.2013.10.014 · Cited by 30

Autophagy is altered in skeletal and cardiac muscle of spontaneously hypertensive rats

Bloemberg, D., McDonald, E. J., Dulay, D., & Quadrilatero, J. (2013) · Acta Physiologica · doi:10.1111/apha.12178 · Cited by 30

Autophagy induction by the 30–100kDa fraction of areca nut in both normal and malignant cells through reactive oxygen species

Lin, M.-H., Hsieh, W.-F., Chiang, W.-F., Hong, W., Hsu, Y.-R., Cheng, Y.-C., Chen, T.-C., Hsu, K., Lina, P.-Y., Liu, S.-Y., et al. (2010) · Oral Oncology · doi:10.1016/j.oraloncology.2010.08.002 · Cited by 30

CHARACTERIZATION OF ATG8 IN LEPIDOPTERAN INSECT CELLS

Gai, Z., Zhang, X., Islam, M., Wang, X., Li, A., Yang, Y., Li, Y., Peng, J., Hong, H., & Liu, K. (2013) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.21114 · Cited by 30

Cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy

Xia, L., Wang, Y., Chen, Y., Yan, J., Fan, H., Su, X., Zhang, C., & Xu, M. (2017) · Oncotarget · doi:10.18632/oncotarget.17854 · Cited by 30

The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress

Mans, L., Cano, L. Q., van Pelt, J., Giardoglou, P., Keune, W., & Haramis, A.-P. G. (2017) · Scientific Reports · doi:10.1038/s41598-017-07116-9 · Cited by 27

Western blot analysis of the autophagosomal membrane protein LGG-1/LC3 in Caenorhabditis elegans.

Springhorn, A., & Hoppe, T. (2019) · Methods in Enzymology · doi:10.1016/bs.mie.2018.12.034 · Cited by 24

Autophagy Mediates Astrogenesis in Adult Hippocampal Neural Stem Cells

Ha, S., Jeong, S.-H., Yi, K., Chu, J. J.-M., Kim, S., Kim, E., & Yu, S. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.2.229 · Cited by 30

Multichannel DNA Sensor Array Fingerprints Cell States and Identifies Pharmacological Effectors of Catabolic Processes

Saha, N. D., Sasmal, R., Meethal, S. K., Vats, S., Gopinathan, P. V., Jash, O., Manjithaya, R. R., Gagey‐Eilstein, N., & Agasti, S. S. (2019) · ACS Sensors · doi:10.1021/acssensors.9b01009 · Cited by 31

Emerging connections between oxidative stress, defective proteolysis, and metabolic diseases

Homma, T., & Fujii, J. (2020) · Free Radical Research · doi:10.1080/10715762.2020.1734588 · Cited by 32

Salidroside-Mediated Autophagic Targeting of Active Src and Caveolin-1 Suppresses Low-Density Lipoprotein Transcytosis across Endothelial Cells

Bai, X., Jia, X., Lu, Y., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/9595036 · Cited by 30

Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals

Kacprzyk, J., Locatelli, A. G., Hughes, G. M., Huang, Z., Clarke, M., Gorbunova, V. A., Sacchi, C., Stewart, G. S., & Teeling, E. C. (2021) · Aging · doi:10.18632/aging.202852 · Cited by 32

Inhibition of GSK-3 ameliorates the pathogenesis of Huntington's disease

Rippin, I., Bonder, K., Joseph, S., Sarsor, A., Vaks, L., & Eldar-Finkelman, H. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105336 · Cited by 30

S-Nitrosylation of cathepsin B affects autophagic flux and accumulation of protein aggregates in neurodegenerative disorders

Kim, K.-R., Cho, E., Eom, J.-W., Oh, S., Nakamura, T., Oh, C.-K., Lipton, S. A., & Kim, Y. H. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01004-0 · Cited by 31

The Role of Traditional Chinese Medicine Natural Products in β-Amyloid Deposition and Tau Protein Hyperphosphorylation in Alzheimer’s Disease

Yan, H., Feng, L., & Li, M. (2023) · Drug Design Development and Therapy · doi:10.2147/dddt.s380612 · Cited by 32

Modulation of pediatric brain tumor autophagy and chemosensitivity

Levy, J. M. M., & Thorburn, A. M. (2011) · Journal of Neuro-Oncology · doi:10.1007/s11060-011-0684-4 · Cited by 30

Suppression of autophagy enhances the cytotoxicity of the DNA-damaging aromatic amine p-anilinoaniline

Elliott, A. A., & Reiners, J. J. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.06.017 · Cited by 30

Involvement of autophagy in recombinant human arginase-induced cell apoptosis and growth inhibition of malignant melanoma cells

Wang, Z., Shi, X., Li, Y., Zeng, X. L., Fan, J., Sun, Y., Xian, Z., Zhang, G., Wang, S., Hu, H., et al. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-5118-0 · Cited by 30

Inhibition of the autophagy flux by gingerol enhances TRAIL-induced tumor cell death

Nazim, U. M., Jeong, J., Seol, J., et al. (2015) · Oncology Reports · doi:10.3892/or.2015.3869 · Cited by 30

Regulation of ubiquitin-proteasome and autophagy pathways after acute LPS and epoxomicin administration in mice

Jamart, C., Gomes, A. V., Dewey, S., Deldicque, L., Raymackers, J., & Francaux, M. (2014) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-15-166 · Cited by 30

Sickness-Associated Anorexia: Mother Nature’s Idea of Immunonutrition?

van Niekerk, G., Isaacs, A. W., Nell, T. A., & Engelbrecht, A. (2016) · Mediators of Inflammation · doi:10.1155/2016/8071539 · Cited by 32

Avian metapneumovirus subgroup C induces autophagy through the ATF6 UPR pathway

Hou, L., Li, W., Zhu, S., Wang, J., Quan, R., Li, Z., & Liu, J. (2017) · Autophagy · doi:10.1080/15548627.2017.1356950 · Cited by 30

Transglutaminase type 2 in the regulation of proteostasis

D’Eletto, M., Rossin, F., Fedorova, O., Farrace, M. G., & Piacentini, M. (2018) · Biological Chemistry · doi:10.1515/hsz-2018-0217 · Cited by 32

Anthraquinones and autophagy – Three rings to rule them all?

Deitersen, J., El‐Kashef, D. H., Proksch, P., & Stork, B. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.115042 · Cited by 32

Clearance of mutant huntingtin

Li, X., Li, H., & Li, S. (2010) · Autophagy · doi:10.4161/auto.6.5.12336 · Cited by 29

Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats

Azimullah, S., Meeran, M. F. N., Ayoob, K., Arunachalam, S., Ojha, S. K., & Beiram, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129876 · Cited by 33

Peste des petits ruminants virus exploits cellular autophagy machinery for replication

Zhang, Y., Wu, S., Lv, J., Feng, C., Deng, J., Wang, C., Yuan, X., Zhang, T., & Lin, X. (2013) · Virology · doi:10.1016/j.virol.2012.12.011 · Cited by 29

Antiapoptotic and Antiautophagic Effects of Eicosapentaenoic Acid in Cardiac Myoblasts Exposed to Palmitic Acid

Cetrullo, S., Tantini, B., Flamigni, F., Pazzini, C., Facchini, A., Stefanelli, C., Caldarera, C. M., & Pignatti, C. (2012) · Nutrients · doi:10.3390/nu4020078 · Cited by 29

Dysregulation of Parkin-mediated mitophagy in thyroid Hürthle cell tumors

Lee, J., Ham, S., Lee, M. H., Kim, S. J., Park, J. H., Lee, S. E., Chang, J. Y., Joung, K. H., Kim, T. Y., Kim, J., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv122 · Cited by 33

Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice

Aumailley, L., Garand, C., Dubois, M. J., Johnson, F. B., Marette, A., & Lebel, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140292 · Cited by 29

Autophagy inhibition in endogenous and nutrient‐deprived conditions reduces dorsal root ganglia neuron survival and neurite growth in vitro

Clarke, J.-P. W. E., & Mearow, K. M. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23733 · Cited by 30

p62/sequestosome 1 in human colorectal carcinoma as a potent prognostic predictor associated with cell proliferation

Nakayama, S., Karasawa, H., Suzuki, T., Yabuuchi, S., Takagi, K., Aizawa, T., Onodera, Y., Nakamura, Y., Watanabe, M., Fujishima, F., et al. (2017) · Cancer Medicine · doi:10.1002/cam4.1093 · Cited by 29

Angiotensin II induces calcium-mediated autophagy in podocytes through enhancing reactive oxygen species levels

Gao, N., Wang, H., Yin, H., & Yang, Z. R. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.09.010 · Cited by 30

Lup-20(29)-en-3β,28-di-yl-nitrooxy acetate affects MCF-7 proliferation through the crosstalk between apoptosis and autophagy in mitochondria

Yan, X., Yang, L., Feng, G., Yu, Z., Xiao, M., Cai, W., Xing, Y., Bai, S., Guo, J., Wang, Z., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0255-5 · Cited by 30

Signaling Lymphocyte Activation Molecule Family 5 Enhances Autophagy and Fine-Tunes Cytokine Response in Monocyte-Derived Dendritic Cells via Stabilization of Interferon Regulatory Factor 8

Agod, Z., Pázmándi, K., Bencze, D., Vereb, G., Bı́ró, T., Szabó, A., Rajnavölgyi, É., Bácsi, A., Engel, P., & Lányi, Á. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00062 · Cited by 29

Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin

Huang, Y., Chen, Y., Shaw, A., Goldfine, H., Tian, J., & Cai, J.-Y. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/5073420 · Cited by 28

TNFAIP8L2/TIPE2 impairs autolysosome reformation via modulating the RAC1-MTORC1 axis

Li, W., Li, Y., Guan, Y., Du, Y., Zhao, M., Chen, X., Zhu, F., Guo, C. H., Jia, Y., Li, Y., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1761748 · Cited by 29

ALS-associated TBK1 variant p.G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation

Foster, A., Downing, P., Figredo, E., Polain, N., Stott, A., Layfield, R., & Rea, S. L. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103539 · Cited by 29

Fine particulate matter inhibits phagocytosis of macrophages by disturbing autophagy

Li, Y., Yong, Y., Yang, M., Wang, W., Qu, X., Dang, X., Shang, D., Shao, Y., Liu, J., & Chang, Y. (2020) · The FASEB Journal · doi:10.1096/fj.202000657r · Cited by 32

Nesfatin-1 Promotes the Osteogenic Differentiation of Tendon-Derived Stem Cells and the Pathogenesis of Heterotopic Ossification in Rat Tendons via the mTOR Pathway

Xu, K., Zhang, Z., Chen, M., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.547342 · Cited by 29

Autophagy Induction as a Host-Directed Therapeutic Strategy against Mycobacterium tuberculosis Infection

Adikesavalu, H., Gopalaswamy, R., Kumar, A., Ranganathan, U. D., & Shanmugam, S. (2021) · Medicina · doi:10.3390/medicina57060522 · Cited by 31

SphK1‐driven autophagy potentiates focal adhesion paxillin‐mediated metastasis in colorectal cancer

Wu, J., Lin, L., Luo, S., et al. (2021) · Cancer Medicine · doi:10.1002/cam4.4129 · Cited by 29

Silibinin eliminates mitochondrial ROS and restores autophagy through IL6ST/JAK2/STAT3 signaling pathway to protect cardiomyocytes from doxorubicin-induced injury

Li, W., Qu, X., Kang, X., Zhang, H., Zhang, X., Hu, H., Yao, L., Zhang, L., Zheng, J., Zheng, Y., et al. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175153 · Cited by 30

Targeted Co-Delivery of Gefitinib and Rapamycin by Aptamer-Modified Nanoparticles Overcomes EGFR-TKI Resistance in NSCLC via Promoting Autophagy

Liu, Y., Dai, X., Jiang, S., Qahar, M., Feng, C., Guo, D., Wang, L., Ma, S., & Huang, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148025 · Cited by 30

A secretory form of Parkin‐independent mitophagy contributes to the repertoire of extracellular vesicles released into the tumour interstitial fluid in vivo

Howard, M., Erickson, J. W., Cuba, Z., Kim, S., Zhou, W., Gade, P. V., Carter, R., Mitchell, K. C., Branscome, H., Siddhi, D., et al. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12244 · Cited by 31

Paeoniflorin, ferulic acid, and atractylenolide III improved LPS-induced neuroinflammation of BV2 microglia cells by enhancing autophagy

Zhou, X., Chen, X., Cheng, X., Lin, L., Quan, S., Li, S., Zhan, R., Wu, Q., & Liu, S. (2023) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2023.04.007 · Cited by 30

Autophagy is Involved in the Initiation and Progression of Graves' Orbitopathy

Yoon, J. S., Lee, H. J., Chae, M. K., & Lee, E. J. (2015) · Thyroid · doi:10.1089/thy.2014.0300 · Cited by 29

Genistein enhances TRAIL-induced cancer cell death via inactivation of autophagic flux

Nazim, U. M., & Park, S. (2015) · Oncology Reports · doi:10.3892/or.2015.4247 · Cited by 29

Autophagy is induced by 3β-O-succinyl-lupeol (LD9-4) in A549 cells via up-regulation of Beclin 1 and down-regulation mTOR pathway

Hao, J. C., Pei, Y., Ji, G., Li, W., Feng, S., & Qiu, S. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.08.045 · Cited by 29

Trehalose activates autophagy and decreases proteasome inhibitor‐induced endoplasmic reticulum stress and oxidative stress‐mediated cytotoxicity in hepatocytes

Honma, Y., Sato‐Morita, M., Katsuki, Y., Mihara, H., Baba, R., & Harada, M. (2017) · Hepatology Research · doi:10.1111/hepr.12892 · Cited by 30

N-Desmethyldauricine Induces Autophagic Cell Death in Apoptosis-Defective Cells via Ca2+ Mobilization

Law, B. Y. K., Mok, S. W. F., Chen, J., Michelangeli, F., Jiang, Z., Han, Y. K., Qu, Y. Q., Qiu, A. C. L., Xu, S., Xue, W., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00388 · Cited by 29

Walsuronoid B induces mitochondrial and lysosomal dysfunction leading to apoptotic rather than autophagic cell death via ROS/p53 signaling pathways in liver cancer

Geng, Y., Zhang, C., Lei, J.-L., Yu, P., Xia, Y., Zhang, H., Yang, L., & Kong, L. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.06.134 · Cited by 29

Oxidative stress-elicited autophagosome accumulation contributes to human neuroblastoma SH-SY5Y cell death induced by PBDE-47

Zhang, C., Li, P., Zhang, S., Lei, R., Li, B., Wu, X. Y., Jiang, C., Zhang, X., Ma, R., Yang, L., et al. (2017) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2017.10.007 · Cited by 29

SGK1 Inhibits Autophagy in Murine Muscle Tissue

Zuleger, T., Heinzelbecker, J., Takács, Z., Hunter, C., Voelkl, J. G. J., Lang, F. J. W., & Proikas‐Cezanne, T. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4043726 · Cited by 29

Crosstalk between Autophagy and Nanomaterials: Internalization, Activation, Termination

Wei, F., & Duan, Y. (2018) · Advanced Biosystems · doi:10.1002/adbi.201800259 · Cited by 29

Acupuncture promotes nerve repair through the benign regulation of mTOR‐mediated neuronal autophagy in traumatic brain injury rats

Zhao, S., Wang, S., Cao, L., Zeng, H., Lin, S., Lin, Z., Chen, M., Mingmin, Z., Pang, Z., & Zhang, Y. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14018 · Cited by 29

Effects of tension on mitochondrial autophagy and osteogenic differentiation of periodontal ligament stem cells

Shao, X., Hu, Z., Su, H., Wang, Y., & Lin, Y. (2023) · Cell Proliferation · doi:10.1111/cpr.13561 · Cited by 27

Clarithromycin enhances dasatinib-induced cell death in chronic myeloid leukemia cells, by inhibition of late stage autophagy

Schafranek, L., Leclercq, T. M., White, D. L., et al. (2012) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2012.698737 · Cited by 28

Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells

Huang, Y., & Ratovitski, E. A. (2010) · Aging · doi:10.18632/aging.100249 · Cited by 28

Downregulation of pyrroline-5-carboxylate reductase-2 induces the autophagy of melanoma cells via AMPK/mTOR pathway

Ou, R., Zhang, X., Cai, J., Shao, X., Lv, M., Qiu, W., Xuan, X., Liu, J., Li, Z., & Xu, Y. (2015) · Tumor Biology · doi:10.1007/s13277-015-3927-8 · Cited by 27

A role for Glucagon-Like Peptide-1 in the regulation of β-cell autophagy

Arden, C. (2018) · Peptides · doi:10.1016/j.peptides.2017.12.002 · Cited by 28

Infectious Bursal Disease Virus Hijacks Endosomal Membranes as the Scaffolding Structure for Viral Replication

Gimenez, M. C., Zanetti, F., Terebiznik, M. R., Colombo, M. I., & Delgui, L. R. (2018) · Journal of Virology · doi:10.1128/jvi.01964-17 · Cited by 28

LW6 enhances chemosensitivity to gemcitabine and inhibits autophagic flux in pancreatic cancer

Zhang, X., Kumstel, S., Jiang, K., Meng, S., Gong, P., Vollmar, B., & Zechner, D. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2019.04.006 · Cited by 29

Autophagy inhibition enhances Matrine derivative MASM induced apoptosis in cancer cells via a mechanism involving reactive oxygen species-mediated PI3K/Akt/mTOR and Erk/p38 signaling

Zou, Y., Sarem, M., Xiang, S., Hu, H., Xu, W., & Shastri, V. P. (2019) · BMC Cancer · doi:10.1186/s12885-019-6199-7 · Cited by 28

Effect and mechanism of asiatic acid on autophagy in myocardial ischemia‑reperfusion injury in vivo and in vitro

Yi, C., Si, L., Xu, J., Yang, J., Wang, Q., & Wang, X. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.9182 · Cited by 31

Autophagy in cancer biology and therapy

Noor, N., Gammoh, Simon, 。., et al. (2014) · Acta Scientiarum Naturalium Universitatis Sunyatseni

Is Selective Autophagy Distinct from Starvation-Induced Autophagy?

Guillebaud, G., & Germain, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802937-4.00005-3

Bnip3 interacts with LC3 to induce selective removal of endoplasmic reticulum and mitochondria via autophagy

Hanna, R. A. (2011) · eScholarship (California Digital Library) · Cited by 2

Self-consumption: the interplay of autophagy and apoptosis

Mariño, G., Niso-Santano, M., Baehrecke, E. H., & Kroemer, G. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3735 · Cited by 2,172

Posttranslational Modifications of Autophagy-related Proteins

Qian, H. (2013) · Zhongguo shengwu huaxue yu fenzi shengwu xuebao