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Autophagy is required for tolerance of drought and salt stress in plants
Open accessAbstract
Autophagy is a protein degradation process in which cells recycle cytoplasmic contents when subjected to environmental stress conditions or during certain stages of development. Upon the induction of autophagy, a double membrane autophagosome forms around cytoplasmic components and delivers them to the vacuole or lysosome for degradation. In plants, autophagy has been shown previously to be induced during abiotic stresses including nutrient starvation and oxidative stress. In this paper, we demonstrate the induction of autophagy in high salt and osmotic stress conditions, concomitant with the upregulation of expression of an Arabidopsis thaliana autophagy-related gene AtATG18a. Autophagy-defective RNAi-AtATG18a plants are more sensitive to salt and drought conditions than wild-type plants, demonstrating a role for autophagy in the response to these stresses. NADPH oxidase inhibitors block autophagy induction upon nutrient starvation and salt stress, but not during osmotic stress, indicating that autophagy can be activated by NADPH oxidase-dependent or -independent pathways. Together our results indicate that diverse environmental stresses can induce autophagy and that autophagy is regulated by distinct signaling pathways in different conditions.
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“Autophagy is the major pathway by which proteins and organelles are targeted for degradation in the vacuoles of plants (Liu et al., 2009).”
From Responses of Nannochloropsis oceanica IMET1 to Long-Term Nitrogen Starvation and Recovery (2013) · cites this paper as Liu et al., 2009
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“Plant autophagy is thought to play an important role in nutrient recycling under starvation (Liu et al., 2009).”
From Responses of Nannochloropsis oceanica IMET1 to Long-Term Nitrogen Starvation and Recovery (2013) · cites this paper as Liu et al., 2009
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Metadata
- Authors
- Liu, Y., Xiong, Y., & Bassham, D. C.
- Affiliations
- Iowa State University (US)
- Corresponding author
- Bassham, Diane C.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2009-10
- Volume
- 5
- Issue
- 7
- Pages
- 954-963
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W2045981379
- Cited by
- 422
- References
- 0
- Citations by year
- 2026: 19 · 2025: 31 · 2024: 39 · 2023: 25 · 2022: 40 · 2021: 37 · 2020: 43 · 2019: 26 · 2018: 25 · 2017: 37 · 2016: 18 · 2015: 20 · 2014: 16 · 2013: 12 · 2012: 17
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Autophagy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0515998)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- drought stress, salt stress, osmotic stress, Arabidopsis thaliana, stress tolerance, NADPH oxidase, nutrient deprivation, oxidative stress, stress signaling pathways
- MeSH terms
- Autophagy-Related Proteins, Autophagy, Enzyme Inhibitors, Imidazoles, Mannitol, Osmotic Pressure, Sodium Chloride, Stress, Physiological, Signal Transduction, Arabidopsis, NADPH Oxidases, Arabidopsis Proteins, RNA Interference, Droughts
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