The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1
Open accessAbstract
Macroautophagy (autophagy) is the major intracellular degradation pathway for long-lived proteins and organelles. It helps the cell to survive a spectrum of stressful conditions including starvation, growth factor deprivation and misfolded protein accumulation. Moreover, abnormalities of autophagy play a role in major health problems including cancer and neurodegenerative diseases. Yet, mechanisms controlling autophagic activity are not fully understood. Here, we describe hsa-miR-376b (miR-376b) as a new microRNA (miRNA) regulating autophagy. We showed that miR-376b expression attenuated starvation- and rapamycin-induced autophagy in MCF-7 and Huh-7 cells. We discovered autophagy proteins ATG4C and BECN1 (Beclin 1) as cellular targets of miR-376b. Indeed, upon miRNA overexpression, both mRNA and protein levels of ATG4C and BECN1 were decreased. miR-376b target sequences were present in the 3' UTR of ATG4C and BECN1 mRNAs and introduction of mutations abolished their miR-376b responsiveness. Antagomir-mediated inactivation of the endogenous miR-376b led to an increase in ATG4C and BECN1 levels. Therefore, miR-376b controls autophagy by directly regulating intracellular levels of two key autophagy proteins, ATG4C and BECN1.
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Cites
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“The other target, ATG4C, has been shown to function in autophagic membrane elongation through its effects on the maturation of LC3 proteins.(18,19,22,23) ATG4B rather than ATG4C was responsible for LC3 protein delipidation, an event important for autophagosome/late endosome-lysosome fusion and LC3 protein recycling.”
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Cited by
Salminen, A., Kaarniranta, K., Kauppinen, A., Ojala, J., Haapasalo, A., Soininen, H., & Hiltunen, M. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.002 · Cited by 364
MicroRNAs in apoptosis, autophagy and necroptosis
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Feng, Y., Yao, Z., & Klionsky, D. J. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.02.002 · Cited by 296
MicroRNA regulation of autophagy
Frankel, L. B., & Lund, A. H. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs266 · Cited by 256
Nguyen, H. T. T., Dalmasso, G., Müller, S., Carrière, J., Seibold, F., & Darfeuille–Michaud, A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.10.021 · Cited by 245
Metadata
- Authors
- Korkmaz, G., le Sage, C., Tekirdag, K. A., Agami, R., & Gozuacik, D.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2012-02
- Volume
- 8
- Issue
- 2
- Pages
- 165-176
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W2058167857
- Cited by
- 245
- References
- 13
- FWCI
- 17.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Korkmaz, G., le Sage, C., Tekirdag, K. A., Agami, R., & Gozuacik, D. (2012). miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. Autophagy. https://doi.org/10.4161/auto.8.2.18351
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