The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
VEGF and Notch Signaling: The Yin and Yang of Angiogenic Sprouting
Open accessAbstract
Tubular sprouting in angiogenesis relies on division of labour between endothelial tip cells, leading and guiding the sprout, and their neighboring stalk cells, which divide and form the vascular lumen. We previously learned how the graded extracellular distribution of heparin-binding vascular endothelial growth factor (VEGF)-A orchestrates and balances tip and stalk cell behavior. Recent data now provided insight into the regulation of tip cell numbers, illustrating how delta-like (DII)4-Notch signalling functions to limit the explorative tip cell behavior induced by VEGF-A. These data also provided a first answer to the question why not all endothelial cells stimulated by VEGF-A turn into tip cells. Here we review this new model and discuss how VEGF-A and DII4/Notch signalling may interact dynamically at the cellular level to control vascular patterning.
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Cites
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894
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Cited by
VEGF in signaling and disease: beyond discovery and development
Apte, R. S., Chen, D. S., & Ferrara, N. (2019) · Cell · doi:10.1016/j.cell.2019.01.021 · Cited by 2,721
Lee, C., Kim, M.-J., Kumar, A., Lee, H.-W., Yang, Y., & Kim, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02249-0 · Cited by 365
Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis
Phng, L.-K., Potente, M., Leslie, J. D., Babbage, J., Nyqvist, D., Lobov, I., Ondr, J. K., Rao, S., Lang, R. A., Thurston, G., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2008.12.009 · Cited by 349
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Metadata
- Authors
- Hellström, M., Phng, L.-K., & Gerhardt, H.
- Venue
- Cell Adhesion & Migration
- Publisher
- Informa UK Limited
- Published
- 2007-07
- Volume
- 1
- Issue
- 3
- Pages
- 133-136
- ISSN
- 1933-6918 (ISSN-L)
- 1933-6926
- OpenAlex
- W2166807613
- Cited by
- 167
- References
- 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hellström, M., Phng, L.-K., & Gerhardt, H. (2007). VEGF and Notch Signaling: The Yin and Yang of Angiogenic Sprouting. Cell Adhesion & Migration. https://doi.org/10.4161/cam.1.3.4978
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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