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Glucose regulated proteins in cancer progression, Drug resistance and immunotherapy
Open accessAbstract
It has been established that as molecular chaperones, the glucose-regulated proteins (GRPs) play an important role in maintaining cellular homeostasis. This conventional concept of GRPs as protein folding chaperones is updated by discoveries that GRPs promote tumor proliferation, metastasis, drug resistance, immunotherapy, which have major clinical implications in the prognosis and treatment of cancer. Further, the localization of GRPs on the cell surface of certain cell types suggests that they serve new functions as cell surface receptors for signaling. These and other new developments on the role of GRP78, GRP94 and GRP170 in cancer progression and therapy are discussed in this review.
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Cited by
Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp
Alfarouk, K. O., Stock, C.-M., Taylor, S., Walsh, M., Muddathir, A. K., Verduzco, D., Bashir, A. H. H., Mohammed, O. Y., Elhassan, G. O., Harguindey, S., et al. (2015) · Cancer Cell International · doi:10.1186/s12935-015-0221-1 · Cited by 665
Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential
Lee, A. S. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3701 · Cited by 587
Self-citationDong, D., Ni, M., Li, J., Xiong, S., Ye, W., Virrey, J. J., Mao, C., Ye, R., Wang, M., Pen, L., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2950 · Cited by 375
Self-citationEndoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy
Schönthal, A. H. (2012) · Scientifica · doi:10.6064/2012/857516 · Cited by 353
Fu, Y., Li, J., & Lee, A. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4594 · Cited by 304
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Metadata
- Authors
- Fu, Y., & Lee, A. S.
- Venue
- Cancer Biology & Therapy
- Publisher
- Informa UK Limited
- Published
- 2006-07
- Volume
- 5
- Issue
- 7
- Pages
- 741-744
- ISSN
- 1538-4047 (ISSN-L)
- 1555-8576
- OpenAlex
- W1993822183
- Cited by
- 219
- References
- 0
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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