The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
From Plk1 to Plk5: Functional evolution of polo-like kinases
Open accessAbstract
Mammalian polo-like kinases (Plks) are characterized by the presence of an N-terminal protein kinase domain and a C-terminal polo-box domain (PBD) involved in substrate binding and regulation of kinase activity. Plk1-4 have traditionally been linked to cell cycle progression, genotoxic stress and, more recently, neuron biology. Recently, a fifth mammalian Plk family member, Plk5, has been characterized in murine and human cells. Plk5 is expressed mainly in differentiated tissues such as the cerebellum. Despite apparent loss of catalytic activity and a stop codon in the middle of the human gene, Plk5 proteins retain important functions in neuron biology. Notably, its expression is silenced by epigenetic alterations in brain tumors, such as glioblastomas, and its re-expression prevents cell proliferation of these tumor cells. In this review, we will focus on the non-cell cycle roles of Plks, the biology of the new member of the family and the possible kinase- and PBD-independent functions of polo-like kinases.
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Cites
The protein kinase complement of the human genome
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Self-citationPolo-like kinases and the orchestration of cell division
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The Polo kinase Plk4 functions in centriole duplication
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Proteomic Screen Finds pSer/pThr-Binding Domain Localizing Plk1 to Mitotic Substrates
Elia, A. E. H., Cantley, L. C., & Yaffe, M. B. (2003) · Science · doi:10.1126/science.1079079 · Cited by 684
Plk4-Induced Centriole Biogenesis in Human Cells
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The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1
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Plk1 Inhibitors in Cancer Therapy: From Laboratory to Clinics
Gutteridge, R. E. A., Ndiaye, M. A., Liu, X., & Ahmad, N. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0897 · Cited by 406
Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies
Kawahata, I., Finkelstein, D. I., & Fukunaga, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116216 · Cited by 102
Therapeutic Targets of KRAS in Colorectal Cancer
Rahman, S., Garrel, S., Gerber, M., Maitra, R., & Goel, S. (2021) · Cancers · doi:10.3390/cancers13246233 · Cited by 28
Metadata
- Authors
- de Cárcer, G., Manning, G., & Malumbres, M.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2011-07-15
- Volume
- 10
- Issue
- 14
- Pages
- 2255-2262
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W1968438075
- Cited by
- 273
- References
- 77
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- de Cárcer, G., Manning, G., & Malumbres, M. (2011). From Plk1 to Plk5: Functional evolution of polo-like kinases. Cell Cycle. https://doi.org/10.4161/cc.10.14.16494
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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