Rapamycin-Induced Glucose Intolerance: Hunger or Starvation Diabetes
Open accessAbstract
Rapamycin prolongs healthy lifespan in yeast, flies and mammals and delays age-related diseases, including cancer and atherosclerosis. Rapamycin is considered for prevention of diabetic complications, such as retinopathy and nephropathy, and acute treatment with rapamycin decreases insulin resistance. However, under certain conditions, chronic administration of rapamycin may cause glucose intolerance and even provoke type II diabetes. This does not fit logically with its potential effects against diabetic complications. This also seems puzzling, because calorie restriction (CR) can prevent type II diabetes and its complications, and rapamycin mimics CR. It was somehow forgotten that almost two centuries ago, Claude Bernard discovered "starvation diabetes," as shown later, characterized by glucose intolerance, decreased insulin, increased lipoproteins and ketones, gluconeogenesis and hepatic resistance to insulin. This reversible condition is not true diabetes: it does not lead to diabetic complications, and CR extends healthy lifespan. If rapamycin is a CR-mimetic, no wonder it may, in certain models, induce "hunger diabetes." But will rapamycin prevent true type II diabetes? Here are some answers.
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Blagosklonny argued that the metabolic side effects of rapamycin are a consequence of it acting as a CRM and are required to mediate its positive effects on lifespan.
“Blagosklonny argued that the metabolic side effects of rapamycin are a consequence of it acting as a CRM and are required to mediate its positive effects on lifespan (226).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [226]
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- Authors
- Blagosklonny, M. V.
- Affiliations
- Roswell Park Comprehensive Cancer Center (US)
- Corresponding author
- Blagosklonny, Mikhail V
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2011-12-15
- Volume
- 10
- Issue
- 24
- Pages
- 4217-4224
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W1981104548
- Cited by
- 59
- References
- 0
- Citations by year
- 2025: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 9 · 2012: 11
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Cycle (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- rapamycin, impaired glucose tolerance, type 2 diabetes, caloric restriction, insulin resistance, hepatic insulin resistance, gluconeogenesis, healthspan, diabetes complications
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Models, Biological, Glucose Intolerance, Ribosomal Protein S6 Kinases, Sirolimus, Caloric Restriction, Diabetes Complications, Insulin-Secreting Cells, TOR Serine-Threonine Kinases
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