Radiation-induced cellular senescence results from a slippage of long-term G 2 arrested cells into G 1 phase
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Diploid cells undergoing senescence and mitotic slippage have been reported in the literature. However, the mechanisms triggering senescence in long-term G2-arrested cells are currently unclear. Previously, we reported that the cell cycle of the human uveal melanoma cell line, 92-1, is suspended for up to 6 d upon exposure to 10 Gy ionizing radiation (IR), followed by senescence. In the current study, we initially distinguished senescence in long-term blocked 92-1 cells from mitotic slippage by confirming the blockage of cells in the G2 phase. We subsequently showed that the genes essential for G2-M transition are prematurely downregulated at both the transcriptional and translational levels. Furthermore, levels of the G1-specific markers, Cyclin D1 and Caveolin-1, were distinctly increased, while S/G2-specific markers, Cyclin B1 and Aurora A, were significantly downregulated. These findings collectively imply that long-term G2-arrested cells undergo senescence via G2 slippage. To our knowledge, this is the first study to report that the cellular process of G2 slippage is the mechanism responsible for senescence of cells under long-term G2 arrest.
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Radiation-induced senescence results from mitotic bypass of stably G2-arrested cells into tetraploid G1, where cyclin D1 accumulates.
“Ye el al. showed that radiation-induced cellular senescence results from mitotic bypass of stably G2arrested cells into a tetraploid G1 phase, where they accumulate cyclin D1. 90”
From Senescence from G2 arrest, revisited (2015) · cites this paper as [90]
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References 48 · Cited by 43
Research works printed but not linked: 1
- Hinz M, Krappmann D, Eichten A, Heder A, Scheidereit C, Strauss M. NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 1999; 19:2690-8; PMID:10082535
- Authors
- Ye, C., Zhang, X., Wan, J., Chang, L., Hu, W., Bing, Z., Zhang, S., Li, J., He, J., Wang, J., & Zhou, G.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Wang, Jufang
- Zhou, Guangming
- ORCID
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2013-05
- Volume
- 12
- Issue
- 9
- Pages
- 1424-1432
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- PMC
- PMC3674070
- OpenAlex
- W1995299918
- Cited by
- 43
- References
- 48
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 5 · 2013: 3
- FWCI
- 4.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Cycle (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- radiation-induced senescence, cellular senescence, mitotic slippage, G2 cell cycle arrest, ionizing radiation, uveal melanoma, cyclin D1, caveolin-1, cyclin B1, AURKA, G1 phase
- MeSH terms
- Gene Expression Regulation, Humans, Mitosis, Radiation, Ionizing, Time Factors, X-Rays, Signal Transduction, Down-Regulation, G1 Phase, Cellular Senescence, Statistics, Nonparametric, Cell Line, Tumor, Receptors, Notch, G2 Phase Cell Cycle Checkpoints
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