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Cited by 14Wnt/β-catenin signaling in development and cancerProtein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Lkb1 and GSK3b: Kinases at the Center (and the poles) of the Action

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Green, Jeremy B.A.·2004·Cell Cycle
DOI 10.4161/cc.3.1.619
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  • LKB-1 phosphorylates and activates PAR-1, but also phosphorylates the inactivating Ser-9 on GSK-3β and may be the elusive GSK-3β kinase activated by Wnt signaling.

    “LKB-1 phosphorylates and activates PAR-1 (120,122,123), but also phosphorylates the inactivating Ser-9 on GSK-3β and may be the elusive GSK-3β kinase activated by Wnt signaling (124).”

    From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [124]

    In “Kinases at the Center and Poles of the Action” (page not available), the paper says Lkb1 regulates inhibitory Ser-9 phosphorylation of GSK-3β, but does not say Lkb1 directly phosphorylates that site. It also says Ser-9 phosphorylation is not a step in Wnt signal transduction, so it does not support identifying Lkb1 as a GSK-3β kinase activated by Wnt. The PAR-1 clause has separate citations and is not assessed here. (LLM, conf=0.88)

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Authors
Green, J. B. A.
Corresponding author
Green, Jeremy B.A.
ORCID
Green, Jeremy B.A.
Venue
Cell Cycle
Publisher
Informa UK Limited
Published
2004-01
Volume
3
Issue
1
Pages
11-13
ISSN
  • 1538-4101 (ISSN-L)
  • 1551-4005
DOI
10.4161/cc.3.1.619
OpenAlex
W1969286584
Cited by
14
References
0
Citations by year
2014: 2 · 2012: 2
FWCI
0.83
Type
journal article
Language
en
Open access
Locations
Cell Cycle (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords
LKB1, GSK3β, kinases, cell polarity, Wnt signaling, cell cycle regulation

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