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Cited by 12

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Integrin Signaling and Lipid Rafts

Pozo, Miguel A. Del·2004·Cell Cycle
DOI 10.4161/cc.3.6.952
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Abstract

Integrin-mediated adhesion regulates the recruitment of the small GTPase Rac to the plasma membrane and subsequent activation of downstream signaling. We recently reported that Rac binds preferentially to cholesterol-rich membranes ("lipid rafts"), and integrins regulate Rac function by preventing the internalization of its binding sites within these domains. Regulation of lipid rafts by integrins may be important for the spatial control of cell migration and signaling pathways involved in anchorage-dependent cell growth.

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Metadata

Authors
Pozo, M. A. D.
Venue
Cell Cycle
Publisher
Informa UK Limited
Published
2004-06
Volume
3
Issue
6
Pages
723-726
ISSN
  • 1538-4101
  • 1551-4005
DOI
10.4161/cc.3.6.952
Cited by
12
References
0
Language
en

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