The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
The Life Cycle of C-Myc: From Synthesis to Degradation
Open accessAbstract
The c-Myc transcription factor is a potent regulator of cellular proliferation and cell fate decision. Precise regulation of c-Myc protein levels is essential to maintain normal cell function. In order to maintain proper levels of c-Myc, its protein stability is tightly controlled. c-Myc is degraded through the ubiquitin-proteasome pathway. This perspective discusses a sophisticated and complex signaling pathway that controls the life cycle of c-Myc from protein synthesis to ubiquitin-mediated degradation. The pathway involves Ras-activated kinases, the Pin1 prolyl isomerase, the PP2A phosphatase and a series of c-Myc phosphorylation and dephosphorylation events that control its stability.
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Citations
Cites
Phosphorylation meets ubiquitination: the control of NF-κB activity
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Mechanisms Underlying Ubiquitination
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Induction of apoptosis in fibroblasts by c-myc protein
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The ubiquitin-proteasome proteolytic pathway
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Self-citationMYC oncogenes and human neoplastic disease
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Cited by
Reflecting on 25 years with MYC
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CIP2A inhibits PP2A in human malignancies
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Self-citationFarrell, A. S., & Sears, R. C. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014365 · Cited by 468
Self-citationmTOR , metabolism, and the regulation of T‐cell differentiation and function
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Metadata
- Authors
- Sears, R. C.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2004-09-09
- Volume
- 3
- Issue
- 9
- Pages
- 1131-1135
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W2046405795
- Cited by
- 417
- References
- 63
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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