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Let-7 Prevents Early Cancer Progression by Suppressing Expression of the Embryonic Gene HMGA2
Open accessAbstract
The microRNA let-7 regulates late embryonic development by suppressing expression of a number of genes such as c-myc and RAS as well as the embryonic gene high mobility group, A2 (HMGA2). We now demonstrate that HMGA2 is more efficiently targeted by let-7 than RAS. Its expression inversely correlates with the expression of let-7 in the NCI60 cells lines, and the expression of RAS does not change when amounts of let-7 that efficiently silence expression of HMGA2 are introduced into tumor cells. We did not find a difference in the expression of HMGA2 between primary ovarian cancer samples and matching metastases, suggesting that the expression of HMGA2 represents an early event during cancer progression. The late repression of HMGA2 by let-7 during embryonic development, and the early reexpression of HMGA2 during cancer development, is in line with the hypothesis that cancer development represents a case of reverse embryogenesis.
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Citations
Cited by
Park, S.-M., Gaur, A. B., Lengyel, E., & Peter, M. E. (2008) · Genes & Development · doi:10.1101/gad.1640608 · Cited by 2,272
Self-citationMicroRNAs in Development and Disease
Sayed, D., & Abdellatif, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00006.2010 · Cited by 1,078
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death
Schickel, R., Boyerinas, B., Park, S.-M., & Peter, M. E. (2008) · Oncogene · doi:10.1038/onc.2008.274 · Cited by 719
Self-citationThe let-7 microRNA reduces tumor growth in mouse models of lung cancer
Esquela-Kerscher, A., Trang, P., Wiggins, J. F., Patrawala, L., Cheng, A., Ford, L., Weidhaas, J. B., Brown, D., Bader, A. G., & Slack, F. J. (2008) · Cell Cycle · doi:10.4161/cc.7.6.5834 · Cited by 593
mir-17-92, a cluster of miRNAs in the midst of the cancer network
Olive, V., Jiang, I., & He, L. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.03.004 · Cited by 465
Metadata
- Authors
- Park, S.-M., Shell, S., Radjabi, A. R., Schickel, R., Feig, C., Boyerinas, B., Dinulescu, D. M., Lengyel, E., & Peter, M. E.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2007-11
- Volume
- 6
- Issue
- 21
- Pages
- 2585-2590
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W2067213721
- Cited by
- 242
- References
- 0
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Park, S.-M., Shell, S., Radjabi, A. R., Schickel, R., Feig, C., Boyerinas, B., Dinulescu, D. M., Lengyel, E., & Peter, M. E. (2007). Let-7 Prevents Early Cancer Progression by Suppressing Expression of the Embryonic Gene HMGA2. Cell Cycle. https://doi.org/10.4161/cc.6.21.4845
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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