The DOI matches its Crossref record; 713 of the 713 references it cites were found in a registry or an index.
MicroRNAs in Development and Disease
Abstract
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently introduced an additional level of intricacy to our understanding of gene regulation. There are currently over 10,000 miRNAs that have been identified in a range of species including metazoa, mycetozoa, viridiplantae, and viruses, of which 940, to date, are found in humans. It is estimated that more than 60% of human protein-coding genes harbor miRNA target sites in their 3′ untranslated region and, thus, are potentially regulated by these molecules in health and disease. This review will first briefly describe the discovery, structure, and mode of function of miRNAs in mammalian cells, before elaborating on their roles and significance during development and pathogenesis in the various mammalian organs, while attempting to reconcile their functions with our existing knowledge of their targets. Finally, we will summarize some of the advances made in utilizing miRNAs in therapeutics.
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Cites
8 retracted
RETRACTED: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis
Valastyan, S., Reinhardt, F., Benaich, N., Calogrias, D., Szász, A. M., Wang, Z. C., Brock, J. E., Richardson, A. L., & Weinberg, R. A. (2009) · Cell · doi:10.1016/j.cell.2009.03.047 · Cited by 820
RetractedGarofalo, M., Di Leva, G., Romano, G., Nuovo, G., Suh, S.-S., Ngankeu, A., Taccioli, C., Pichiorri, F., Alder, H., Secchiero, P., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.10.014 · Cited by 733
RetractedRETRACTED: Downregulation of miR‐122 in the rodent and human hepatocellular carcinomas
Kutay, H., Bai, S., Datta, J., Motiwala, T., Pogribny, I., Frankel, W., Jacob, S. T., & Ghoshal, K. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20982 · Cited by 608
RetractedXu, C., Lu, Y., Pan, Z., Chu, W., Luo, X., Lin, H., Xiao, J., Shan, H., Wang, Z., & Yang, B. (2007) · Journal of Cell Science · doi:10.1242/jcs.010728 · Cited by 439
RetractedDatta, J., Kutay, H., Nasser, M. W., Nuovo, G. J., Wang, B., Majumder, S., Liu, C.-G., Volinia, S., Croce, C. M., Schmittgen, T. D., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6655 · Cited by 438
RetractedNasser, M. W., Datta, J., Nuovo, G., Kutay, H., Motiwala, T., Majumder, S., Wang, B., Suster, S., Jacob, S. T., & Ghoshal, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804788200 · Cited by 360
RetractedLuo, X., Lin, H., Pan, Z., Xiao, J., Zhang, Y., Lu, Y., Yang, B., & Wang, Z. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801035200 · Cited by 177
RetractedPrasad, S. V. N., Duan, Z.-H., Gupta, M. K., Surampudi, V. S. K., Volinia, S., Calin, G. A., Liu, C., Kotwal, A., Moravec, C. S., Starling, R. C., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.036541 · Cited by 141
RetractedThe C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
Cited by
Transcriptional Regulation and Its Misregulation in Disease
Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.02.014 · Cited by 1,620
Tham, Y. K., Bernardo, B. C., Ooi, J. Y. Y., Weeks, K. L., & McMullen, J. R. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1477-x · Cited by 708
The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics
Bautista-Sánchez, D., Arriaga-Canon, C., Pedroza-Torres, A., De La Rosa-Velázquez, I. A., González-Barrios, R., Contreras-Espinosa, L., Montiel-Manríquez, R., Castro-Hernández, C., Fragoso-Ontiveros, V., Álvarez-Gómez, R. M., et al. (2020) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2020.03.003 · Cited by 549
Anti-Inflammatory MicroRNAs and Their Potential for Inflammatory Diseases Treatment
Tahamtan, A., Teymoori-Rad, M., Nakstad, B., & Salimi, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01377 · Cited by 357
MicroRNA biogenesis: regulating the regulators
Finnegan, E. F., & Pasquinelli, A. E. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2012.738643 · Cited by 311
Metadata
- Authors
- Sayed, D., & Abdellatif, M.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2011-07
- Volume
- 91
- Issue
- 3
- Pages
- 827-887
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2171260596
- Cited by
- 1,078
- References
- 713
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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