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Cited by 24DNA Repair MechanismsChromatin Remodeling and CancerNuclear Structure and Function

ATR kinase as master regulator of nucleotide excision repair during S phase of the cell cycle

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Auclair, Yannick, Rouget, Raphael, Drobetsky, Elliot A.·2009·Cell Cycle
DOI 10.4161/cc.8.12.8800
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Abstract

Nucleotide excision repair (NER) is a major determinant in cancer development and treatment via its essential role in eliminating highly-genotoxic, helix-distorting DNA adducts that block replication and transcription. Over the years, many elegant studies employing UV as model mutagen have led to a detailed understanding of how the NER pathway itself is coordinated. Nonetheless relatively little is known regarding any precise functions of various preeminent mutagen-responsive signaling cascades lying upstream of NER, notably those mediated by the canonical MAPKs or the PIKK family members ATR and ATM. Here we present a brief overview of NER, mostly in the context of studies on human cells treated with UV, and describe recent results from our laboratory which have significantly elucidated the role of UV-induced signal transduction in this repair pathway.

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  • In mammalian cells, NER also acts in S phase, where GG-NER is enhanced and stimulated by active ATR.

    “In mammalian cells the situation is more complex, because NER acts also in S phase, where GG-NER is enhanced [88] and is stimulated by active ATR [89,90].”

    From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [90]

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Authors
Auclair, Y., Rouget, R., & Drobetsky, E. A.
Affiliations
Hôpital Maisonneuve-Rosemont (CA)
Corresponding author
Drobetsky, Elliot A.
ORCID
Venue
Cell Cycle
Publisher
Informa UK Limited
Published
2009-06-15
Volume
8
Issue
12
Pages
1865-1871
ISSN
  • 1538-4101 (ISSN-L)
  • 1551-4005
DOI
10.4161/cc.8.12.8800
OpenAlex
W2087177695
Cited by
24
References
0
Citations by year
2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 1 · 2013: 2 · 2012: 3
FWCI
1.20
Type
journal article
Language
en
Open access
Locations
  • Cell Cycle (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords
nucleotide excision repair, ATR kinase, S phase, UV-induced DNA damage, DNA adducts, MAPK signaling, DNA damage response, signal transduction, DNA replication
MeSH terms
Cell Cycle, DNA Damage, DNA Repair, DNA-Binding Proteins, Humans, Signal Transduction, S Phase, Protein Serine-Threonine Kinases, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins

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