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Divergent transcription: A new feature of active promoters
Open accessAbstract
Divergent transcription is common of many promoters in organisms as diverse as mammals and yeast. Many independent experiments indicate that RNA polymerase II is frequently initiated but paused in the sense direction downstream from the promoter. Similarly a second peak of transcriptionally-engaged polymerase is paused in the anti-sense direction upstream of the promoter. Chromatin modifications that are associated with active promoters reside in nucleosomes immediately flanking this pair of paused polymerases. The nucleosome-free region associated with most promoters could in part be defined by this divergent transcription. The potential implications of divergent transcription on gene regulation and possible mechanisms that give rise to this phenomenon are discussed.
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Cited by
Nascent transcript sequencing visualizes transcription at nucleotide resolution
Churchman, L. S., & Weissman, J. S. (2011) · Nature · doi:10.1038/nature09652 · Cited by 823
Determinants of enhancer and promoter activities of regulatory elements
Andersson, R., & Sandelin, A. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-019-0173-8 · Cited by 713
Core, L. J., Martins, A. L., Danko, C. G., Waters, C. T., Siepel, A., & Lis, J. T. (2014) · Nature Genetics · doi:10.1038/ng.3142 · Cited by 693
Self-citationLocalization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution
Cabili, M. N., Dunagin, M. C., McClanahan, P. D., Biaesch, A., Padovan-Merhar, O., Regev, A., Rinn, J. L., & Raj, A. (2015) · Genome Biology · doi:10.1186/s13059-015-0586-4 · Cited by 684
Jonkers, I., Kwak, H., & Lis, J. T. (2014) · eLife · doi:10.7554/elife.02407 · Cited by 581
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Metadata
- Authors
- Seila, A. C., Core, L. J., Lis, J. T., & Sharp, P. A.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2009-08-15
- Volume
- 8
- Issue
- 16
- Pages
- 2557-2564
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W2091452413
- Cited by
- 177
- References
- 0
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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