The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?
Open accessAbstract
A cancer cell comprising largely of carbon, hydrogen, oxygen, phosphorus, nitrogen and sulfur requires not only glucose, which is avidly transported and converted to lactate by aerobic glycolysis or the Warburg effect, but also glutamine as a major substrate. Glutamine and essential amino acids, such as methionine, provide energy through the TCA cycle as well as nitrogen, sulfur and carbon skeletons for growing and proliferating cancer cells. The interplay between utilization of glutamine and glucose is likely to depend on the genetic make-up of a cancer cell. While the MYC oncogene induces both aerobic glycolysis and glutaminolysis, activated β-catenin induces glutamine synthesis in hepatocellular carcinoma. Cancer cells that have elevated glutamine synthetase can use glutamate and ammonia to synthesize glutamine and are hence not addicted to glutamine. As such, cancer cells have many degrees of freedom for re-programming cell metabolism, which with better understanding will result in novel therapeutic approaches.
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“Glutamine serves as an anaplerosis substrate to fuel the TCA cycle for energy generation and also provides nitrogen for protein synthesis (Dang, 2010; Wise and Thompson, 2010; DeBerardinis and Cheng, 2010; Daye and Wellen, 2012; Gaglio et al., 2009; Johnson et al., 2003; Rajagopalan and DeBerardinis, 2011; Shanware et al., 2011; Weinberg et al., 2010).”
From Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism (2016) · cites this paper as Dang, 2010
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Research works printed but not linked: 5
- Baggetto LG. Deviant energetic metabolism of glyco- lytic cancer cells. Biochimie 1992; 74:959-74.
- Dang CV. Rethinking the Warburg effect with Myc micromanaging glutamine metabolism. Cancer Res 2010; 70:859-62.
- Weinhouse S. Glycolysis, respiration and anoma- lous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture. Cancer Res 1972; 32:2007-16.
- Linder-Horowitz M, Knox WE, Morris HP. Glutaminase activities and growth rates of rat hepa- tomas. Cancer Res 1969; 29:1195-9.
- Kovacevic Z, Morris HP. The role of glutamine in the oxidative metabolism of malignant cells. Cancer Res 1972; 32:326-33.
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Metadata
- Authors
- Dang, C. V.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Dang, Chi V.
- ORCID
- Dang, Chi V.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2010-10
- Volume
- 9
- Issue
- 19
- Pages
- 3884-3886
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W1986517285
- Cited by
- 245
- References
- 0
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 21 · 2021: 15 · 2020: 15 · 2019: 15 · 2018: 13 · 2017: 18 · 2016: 24 · 2015: 21 · 2014: 25 · 2013: 21 · 2012: 17
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cell Cycle (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- glutaminolysis, glutamine metabolism, cancer metabolism, aerobic glycolysis, Warburg effect, TCA cycle, MYC oncogene, β-catenin, glutamine synthetase, glutamine addiction, hepatocellular carcinoma, methionine, metabolic reprogramming, cancer therapy
- MeSH terms
- Amino Acids, Carbon, Citric Acid Cycle, Energy Metabolism, Glucose, Glutamine, Glycolysis, Humans, Neoplasms, Nitrogen, Proto-Oncogene Proteins c-myc, Glutamic Acid
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