Cited by 245Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and MetabolismCancer, Lipids, and Metabolism

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Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?

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Dang, Chi V.·2010·Cell Cycle

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Abstract

A cancer cell comprising largely of carbon, hydrogen, oxygen, phosphorus, nitrogen and sulfur requires not only glucose, which is avidly transported and converted to lactate by aerobic glycolysis or the Warburg effect, but also glutamine as a major substrate. Glutamine and essential amino acids, such as methionine, provide energy through the TCA cycle as well as nitrogen, sulfur and carbon skeletons for growing and proliferating cancer cells. The interplay between utilization of glutamine and glucose is likely to depend on the genetic make-up of a cancer cell. While the MYC oncogene induces both aerobic glycolysis and glutaminolysis, activated β-catenin induces glutamine synthesis in hepatocellular carcinoma. Cancer cells that have elevated glutamine synthetase can use glutamate and ammonia to synthesize glutamine and are hence not addicted to glutamine. As such, cancer cells have many degrees of freedom for re-programming cell metabolism, which with better understanding will result in novel therapeutic approaches.

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Authors: Dang, C. V.
Affiliations: Johns Hopkins University (US)
Corresponding author: Dang, Chi V.
ORCID: Dang, Chi V.
Venue: Cell Cycle
Publisher: Informa UK Limited
Published: 2010-10
Volume: 9
Issue: 19
Pages: 3884-3886
ISSN: 1538-4101 (ISSN-L)
1551-4005
DOI: 10.4161/cc.9.19.13302
OpenAlex: W1986517285
Cited by: 245
References: 0
Citations by year: 2026: 5 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 21 · 2021: 15 · 2020: 15 · 2019: 15 · 2018: 13 · 2017: 18 · 2016: 24 · 2015: 21 · 2014: 25 · 2013: 21 · 2012: 17
FWCI: 5.18
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cell Cycle (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords: glutaminolysis, glutamine metabolism, cancer metabolism, aerobic glycolysis, Warburg effect, TCA cycle, MYC oncogene, β-catenin, glutamine synthetase, glutamine addiction, hepatocellular carcinoma, methionine, metabolic reprogramming, cancer therapy
MeSH terms: Amino Acids, Carbon, Citric Acid Cycle, Energy Metabolism, Glucose, Glutamine, Glycolysis, Humans, Neoplasms, Nitrogen, Proto-Oncogene Proteins c-myc, Glutamic Acid

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Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?

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