Cited by 245Hidradenitis Suppurativa and TreatmentsAutoimmune and Inflammatory DisordersAcne and Rosacea Treatments and Effects

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Comorbidities of hidradenitis suppurativa (acne inversa)

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Fimmel, Sabine, Zouboulis, Christos C.·2010·Dermato-Endocrinology

DOI 10.4161/derm.2.1.12490PMC PMC3084959

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Abstract

Comorbidities of hidradenitis suppurativa (acne inversa) were reviewed by extracting original and review publications included in MEDLINE, EMBASE and COCHRANE libraries using the terms "hidradenitis," "Verneuil" and "acne inversa." Follicular occlusion disorders, inflammatory bowel diseases, especially Crohn disease, spondylarthropathy, other hyperergic diseases, genetic keratin disorders associated with follicular occlusion and squamous cell carcinoma were the most common hidradenitis suppurativa comorbid diseases. A first classification of these major comorbidities and their possible genetic background reveals a list of chromosome loci and genes, which could be hidradenitis suppurativa candidates. Most of these diseases belong to the group of autoinflammatory disorders, where th17 cell cytokines seem to play a central role.

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Myeloid marker S100A8/A9 and lymphocyte marker, soluble interleukin 2 receptor: biomarkers of hidradenitis suppurativa disease activity?
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Combined fractional carbon dioxide laser and long‐pulsed neodymium : yttrium‐aluminium‐garnet (1064 nm) laser in treatment of hidradenitis suppurativa; a prospective randomized intra‐individual controlled study
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A Molecular Perspective on the Potential Benefits of Metformin for the Treatment of Inflammatory Skin Disorders
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High burden of hospital resource utilization in patients with hidradenitis suppurativa in England: a retrospective cohort study using hospital episode statistics
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Adalimumab for the treatment of hidradenitis suppurativa/acne inversa
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Correlation of the refined Hurley classification for hidradenitis suppurativa with patient‐reported quality of life and objective disease severity assessment
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Hidradenitis suppurativa: Inside and out
Apurwa, A., Patil, S. P., Nadkarni, N. J., Agarwal, S., Chaudhari, P., & Gautam, M. (2018) · Indian Journal of Dermatology · doi:10.4103/ijd.ijd_412_16 · Cited by 39
Prevalence of inflammatory bowel disease (IBD) in hidradenitis suppurativa (HS): systematic review and adjusted meta‐analysis
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Evaluation of medical and surgical treatments for hidradenitis suppurativa using real‐life data from the Scandinavian registry ( HISREG )
Grimstad, Ø., Tzellos, T., Dufour, D. N., Bremnes, Ø. M., Skoie, I. M., Snekvik, I., Jarnæss, E., Kyrgidis, Α., & Ingvarsson, G. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15353 · Cited by 38
Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis
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Unravelling the complex pathogenesis of hidradenitis suppurativa
Frew, J. W. (2024) · British Journal of Dermatology · doi:10.1093/bjd/ljae238 · Cited by 37
Circulating levels of adiponectin, leptin, resistin and visfatin in non-diabetics patients with hidradenitis suppurativa
González-López, M. A., Vilanova, I., Ocejo-Viñals, G., Arlegui, R., Navarro, I., Guiral, S., Mata, C., Pérez-Paredes, M. G., Portilla, V., Corrales, A., et al. (2019) · Archives of Dermatological Research · doi:10.1007/s00403-019-02018-4 · Cited by 37
Actualización en hidradenitis supurativa (ii): aspectos terapéuticos
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Hidradenitis Suppurativa-Like Lesions Associated with Pharmacologic Inhibition of Gamma-Secretase
Coyne, G. O., Woodring, T. S., Lee, C. R., Chen, A. P., & Kong, H. H. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.09.051 · Cited by 35
Hidradenitis suppurativa and polycystic ovarian syndrome: Systematic review and meta‐analysis
Phan, K. H., Charlton, O., & Smith, S. D. (2019) · Australasian Journal of Dermatology · doi:10.1111/ajd.13110 · Cited by 34
Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa
Dany, M., & Elston, D. M. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.03.016 · Cited by 33
Automatic International Hidradenitis Suppurativa Severity Score System (AIHS4): A Novel Tool to Assess the Severity of Hidradenitis Suppurativa Using Artificial Intelligence
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The off-label treatment of severe hidradenitis suppurativa with TNF-α inhibitors: a systematic review
van Rappard, D. C., Limpens, J., & Mekkes, J. R. (2012) · Journal of Dermatological Treatment · doi:10.3109/09546634.2012.674193 · Cited by 32
Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis
Damiani, G. B., Leone, S., Fajgenbaum, K., Bragazzi, N. L., Pacifico, A., Conic, R. R. Z., Pigatto, P. D., Maiorana, C., Poli, P. P., Berti, E., et al. (2019) · World Journal of Hepatology · doi:10.4254/wjh.v11.i4.391 · Cited by 32
Hidradenitis suppurativa: infection, autoimmunity, or both?
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Epidemiology of hidradenitis suppurativa
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Long-Wave Medical Infrared Thermography: A Clinical Biomarker of Inflammation in Hidradenitis Suppurativa/Acne Inversa
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Achieving Hidradenitis Suppurativa Response Score is Associated with Significant Improvement in Clinical and Patient-reported Outcomes: Post Hoc Analysis of Pooled Data From PIONEER I and II
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Practical Guidelines for Managing Patients With Hidradenitis Suppurativa: An Update
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Pathogenetic Characteristics of Mesenchymal Stem Cells in Hidradenitis Suppurativa
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Methylated miRNAs may serve as potential biomarkers and therapeutic targets for hidradenitis suppurativa
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Establishment of a European Registry for hidradenitis suppurativa/acne inversa by using an open source software
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Which hidradenitis suppurativa comorbidities should I take into account?
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Hidradenitis Suppurativa and Bipolar Disorders: A Population-Based Study
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The measurement performance of the EQ-5D-5L versus EQ-5D-3L in patients with hidradenitis suppurativa
Bató, A., Brodszky, V., Gergely, L. H., Gáspár, K., Wikonkál, N. M., Kinyó, Á., Szabó, Á., Beretzky, Z., Szegedi, A., Remenyik, É., et al. (2021) · Quality of Life Research · doi:10.1007/s11136-020-02732-x · Cited by 26
Hidradenitis Suppurativa and Concurrent Psoriasis: Comparison of Epidemiology, Comorbidity Profiles, and Risk Factors
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Epidemiology of Hidradenitis Suppurativa: Prevalence, Pathogenesis, and Factors Associated with the Development of HS
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Comorbidities, treatment, and outcome in severe anogenital inverse acne (hidradenitis suppurativa): a 15-year single center report
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The pharmacology of antibiotic therapy in hidradenitis suppurativa
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Surgical management of hidradenitis suppurativa
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Hidradenitis suppurativa and squamous cell carcinoma: a systemic review of the literature
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Descriptive Epidemiology of Hidradenitis Suppurativa in Greece: A Study of 152 Cases
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A fatal case of hidradenitis suppurativa associated with sepsis and squamous cell carcinoma
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Authors: Fimmel, S., & Zouboulis, C. C.
Affiliations: Stiftung Charité (DE)
Städtisches Klinikum Dessau (DE)
ORCID: Zouboulis, Christos C.
Venue: Dermato-Endocrinology
Publisher: Informa UK Limited
Published: 2010-01
Volume: 2
Issue: 1
Pages: 9-16
ISSN: 1938-1972 (ISSN-L)
1938-1980
DOI: 10.4161/derm.2.1.12490
PMC: PMC3084959
OpenAlex: W2057540123
Cited by: 245
References: 160
Citations by year: 2026: 13 · 2025: 10 · 2024: 21 · 2023: 18 · 2022: 20 · 2021: 21 · 2020: 21 · 2019: 24 · 2018: 21 · 2017: 16 · 2016: 23 · 2015: 22 · 2014: 3 · 2013: 8 · 2012: 2
FWCI: 4.26
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Dermato-Endocrinology (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Hidradenitis Suppurativa and Treatments
Health Sciences › Medicine › Dermatology › Autoimmune and Inflammatory Disorders
Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
Keywords: hidradenitis suppurativa, comorbidities, inflammatory bowel disease, Crohn's disease, spondyloarthritis, hyperkeratosis, squamous cell carcinoma, autoinflammatory disease, Th17 cytokines, genetic susceptibility, candidate genes

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Comorbidities of hidradenitis suppurativa (acne inversa)

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