The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Epigenetic Control of a Transcription Factor at the Cross Section of Two Antagonistic Pathways
Open accessAbstract
The expression of the Arabidopsis gene WRKY70 is known to be antagonistically regulated by the salicylic acid (SA) and jasmonic acid (JA) signaling pathways. The gene encodes a transcription factor functioning at the crossroad of the two pathways. Here we show that the Arabidopsis homolog of Trithorax, ATX1, activates the expression of the WRKY70 gene and is involved in establishing the trimethylation pattern of histone H3 tail lysine 4 (H3K4me3) residues of its nucleosomes. Chromatin immunoprecipitation (ChIP) analyses with antiATX1 specific antibodies demonstrated that WRKY70 is a primary target for the ATX1 histone methylase activity, while the SA-responsive gene, PR1, and the JA-responsive gene, THI2.1, are secondary targets. The unexpected finding that PR1 and THI2.1 nucleosomes carryH3K4me3-marks unrelated to their transcription states suggests that the defense-response genes PR1 and THI2.1 keep their nucleosomes in 'actively' modified state, perhaps, in preparation for quick-changes of transcription when needed by the cell. Based on the experimental data, we propose a model that could explain the ability of a single epigenetic factor to orchestrate expression of a large number of genes, particularly in cases involving response reactions.
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Cites
Regulation of chromatin structure by site-specific histone H3 methyltransferases
Rea, S., Eisenhaber, F., O'Carroll, D., Strahl, B. D., Sun, Z.-W., Schmid, M., Opravil, S., Mechtler, K., Ponting, C. P., Allis, C. D., et al. (2000) · Nature · doi:10.1038/35020506 · Cited by 2,845 · cited 1×
“1-4 The molecular nature of epigenetic mechanisms has been a longstanding enigma until the recent discovery that the SET domain [SuVar(3-9)-E (z)-Trithorax] conserved in both PcG and TrxG components has histone methyltransferase activity.”
BackgroundActive Genes Are Tri-Methylated at K4 of Histone H3
Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature · doi:10.1038/nature01080 · Cited by 2,138
The INK4A/ARF locus and its two gene products.
Sharpless, N. E., & DePinho, R. A. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80004-5 · Cited by 533
Cited by
Rushton, P. J., Somssich, I. E., Ringler, P., & Shen, Q. J. (2010) · Trends in Plant Science · doi:10.1016/j.tplants.2010.02.006 · Cited by 2,700
Systemic Acquired Resistance: Turning Local Infection into Global Defense
Fu, Z. Q., & Dong, X. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042811-105606 · Cited by 1,524
Saleh, A., Alvarez-Venegas, R., & Avramova, Z. (2008) · Nature Protocols · doi:10.1038/nprot.2008.66 · Cited by 641
Self-citationMultiple exposures to drought 'train' transcriptional responses in Arabidopsis
Ding, Y., Fromm, M., & Avramova, Z. (2012) · Nature Communications · doi:10.1038/ncomms1732 · Cited by 637
Self-citationMengiste, T. (2012) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-081211-172955 · Cited by 566
Metadata
- Authors
- Alvarez-Venegas, R., Abdallat, A. A., Guo, M., Alfano, J. R., & Avramova, Z.
- Venue
- Epigenetics
- Publisher
- Informa UK Limited
- Published
- 2007-04-03
- Volume
- 2
- Issue
- 2
- Pages
- 106-113
- ISSN
- 1559-2294 (ISSN-L)
- 1559-2308
- OpenAlex
- W2108325221
- Cited by
- 170
- References
- 3
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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