Cited by 534Cancer-related Molecular PathwaysTelomeres, Telomerase, and SenescenceChromatin Remodeling and Cancer

The INK4A/ARF locus and its two gene products.

Sharpless, Norman E, DePinho, Ronald A·1999·Current Opinion in Genetics & Development

Abstract

The INK4A/ARF locus on chromosome 9 is one of the sites mutated most frequently in human cancer. Two genes comprising overlapping reading frames encoding p16(INK4a) and p19(ARF) have been discovered at this locus and, remarkably, both play an important role in regulating cell growth, survival and senescence.

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Crossref · 10.1016/s0959-437x(99)80004-5

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Authors
Sharpless, N. E., & DePinho, R. A.
Affiliations
Dana-Farber Cancer Institute (US)
Corresponding author
DePinho, Ronald A
Venue
Current Opinion in Genetics & Development
Publisher
Elsevier BV
Published
1999-02
Volume
9
Issue
1
Pages
22-30
ISSN
0959-437X (ISSN-L)
OpenAlex
W1991595805
Cited by
533
References
92
Citations by year
2026: 4 · 2025: 9 · 2024: 8 · 2023: 7 · 2022: 10 · 2021: 15 · 2020: 8 · 2019: 9 · 2018: 11 · 2017: 4 · 2016: 12 · 2015: 9 · 2014: 12 · 2013: 21 · 2012: 15
FWCI
5.41
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Genetics & Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hd028317-05, 7r01ey011267-04)
  • National Eye Institute (R01EY11267)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD28317)
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
INK4a/ARF locus, p16INK4a, p19ARF, chromosome 9, tumor suppressor, cell cycle regulation, cellular senescence, cell growth, cell survival, cancer mutations
MeSH terms
Amino Acid Sequence, Humans, Molecular Sequence Data, Mutation, Neoplasms, Proteins, Genes, Tumor Suppressor, Sequence Homology, Amino Acid, Cyclin-Dependent Kinase Inhibitor p16, Genes, p16, Tumor Suppressor Protein p14ARF

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