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The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Maternal tobacco use modestly alters correlated epigenome-wide placental DNA methylation and gene expression

Suter, Melissa, Ma, Jun, Harris, Alan S., Patterson, Lauren, Brown, Kathleen A., Shope, Cynthia, Showalter, Lori, Abramovici, Adi, Aagaard-Tillery, Kjersti M.·2011·Epigenetics
DOI 10.4161/epi.6.11.17819
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Abstract

Several studies linking alterations in differential placental methylation with pregnancy disorders have implicated (de)regulation of the placental epigenome with fetal programming and later-in-life disease. We have previously demonstrated that maternal tobacco use is associated with alterations in promoter methylation of placental CYP1A1 and that these changes are correlated with CYP1A1 gene expression and fetal growth restriction. In this study we sought to expand our analysis of promoter methylation by correlating it to gene expression on a genome-wide scale. Employing side-by-side IlluminaHG-12 gene transcription with Infinium27K methylation arrays, we interrogated correlative changes in placental gene expression and DNA methylation associated with maternal tobacco smoke exposure at an epigenome-wide level and in consideration of signature gene pathways. We observed that the expression of 623 genes and the methylation of 1024 CpG dinucleotides are significantly altered among smokers, with only 38 CpGs showing significant differential methylation (differing by a methylation level of ≥10%). We identified a significant Pearson correlation (≥0.7 or ≤-0.7) between placental transcriptional regulation and differential CpG methylation in only 25 genes among non-smokers but in 438 genes among smokers (18-fold increase, p < 0.0001), with a dominant effect among oxidative stress pathways. Differential methylation at as few as 6 sites was attributed to maternal smoking-mediated birth…

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Citations

Cites

Research works printed but not linked: 29

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Metadata

Authors
Suter, M., Ma, J., Harris, A. S., Patterson, L., Brown, K. A., Shope, C., Showalter, L., Abramovici, A., & Aagaard-Tillery, K. M.
Venue
Epigenetics
Publisher
Informa UK Limited
Published
2011-11
Volume
6
Issue
11
Pages
1284-1294
ISSN
  • 1559-2294
  • 1559-2308
DOI
10.4161/epi.6.11.17819
Cited by
243
References
2
Language
en

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