Double vision: Pigment genes do more than just color
Open accessAbstract
The use of P element collections led to the discovery of unanticipated effects from common genetic background mutants white, brown, and rosy in our previously reported model of tauopathy that expresses full-length human tau in the fly eye, in which mutant rosy suppresses mutant white and brown worsening of tau-induced toxicity (Ambegaokar & Jackson, 2010, Genetics, v. 186, p. 435-42). Here we discuss further possible effects of mini-white and evidence for autophagy as a mediator of white enhancement of tau toxicity.
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Target of rapamycin-regulated autophagy is activated dose-dependently by white mutations.
“we observe a decrease in phospho-S6K in white homozygotes when compared with white hetereozygotes, suggesting that target of rapamycin-regulated autophagy is activated dose-dependently by white mutations (189).”
From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [189]
white homozygotes show a decrease in phospho-S6K compared with white heterozygotes.
“we observe a decrease in phospho-S6K in white homozygotes when compared with white hetereozygotes, suggesting that target of rapamycin-regulated autophagy is activated dose-dependently by white mutations (189).”
From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [189]
Cites
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
Wang, Y., Martinez-Vicente, M., Krüger, U., Kaushik, S., Wong, E., Mandelkow, E.-M., Cuervo, A. M., & Mandelkow, E. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp367 · Cited by 617 · see citing works
Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization
Sjöberg, M. K., Shestakova, E., Mansuroglu, Z., Maccioni, R. B., & Bonnefoy, E. (2006) · Journal of Cell Science · doi:10.1242/jcs.02907 · Cited by 166 · see citing works
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Ambegaokar, S. S., & Jackson, G. R. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr432 · Cited by 113 · see citing works
“Mutations in white and brown lead to abnormally large pigment granules that become abnormal autolysosomes (187,188), and we observe a decrease in phospho-S6K in white homozygotes when compared with white hetereozygotes, suggesting that target of rapamycin-regulated autophagy is activated dose-dependently by white muta…”
BackgroundSelf-citation
- Authors
- Ambegaokar, S. S., & Jackson, G.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Corresponding author
- Jackson, George
- Venue
- Fly
- Publisher
- Informa UK Limited
- Published
- 2011-07
- Volume
- 5
- Issue
- 3
- Pages
- 206-209
- ISSN
- 1933-6934 (ISSN-L)
- 1933-6942
- PMC
- PMC3225764
- OpenAlex
- W2077439711
- Cited by
- 2
- References
- 2
- Citations by year
- 2019: 1
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Fly (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Health Assistance Foundation
- National Institutes of Health
- National Institute on Aging (P50AG016570, AG 16570)
- National Institute of Neurological Disorders and Stroke (NS04648)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- tauopathy, Drosophila eye, white mutant, P-element mutagenesis, autophagy, tau toxicity, genetic background effects
- MeSH terms
- Animals, Autophagy, Color, Drosophila, Humans, Pigments, Biological, tau Proteins, Compound Eye, Arthropod
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