Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization
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The microtubule-associated tau protein participates in the organization and integrity of the neuronal cytoskeleton. A nuclear form of tau has been described in neuronal and non-neuronal cells, which displays a nucleolar localization during interphase but is associated with nucleolar-organizing regions in mitotic cells. In the present study, based on immunofluorescence, immuno-FISH and confocal microscopy, we show that nuclear tau is mainly present at the internal periphery of nucleoli, partially colocalizing with the nucleolar protein nucleolin and human AT-rich α-satellite DNA sequences organized as constitutive heterochromatin. By using gel retardation, we demonstrate that tau not only colocalizes with, but also specifically binds to, AT-rich satellite DNA sequences apparently through the recognition of AT-rich DNA stretches. Here we propose a functional role for nuclear tau in relation to the nucleolar organization and/or heterochromatinization of a portion of RNA genes. Since nuclear tau has also been found in neurons from patients with Alzheimer's disease (AD), aberrant nuclear tau could affect the nucleolar organization during the course of AD. We discuss nucleolar tau associated with AT-rich α-satellite DNA sequences as a potential molecular link between trisomy 21 and AD.
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Tau is thought to protect DNA from oxidative damage.
“and is thought to protect DNA from oxidative damage46-48”
From Tau promotes neurodegeneration through global chromatin relaxation (2014) · cites this paper as [47]
In vitro and in cultured cells, tau binds the minor groove of the DNA double helix.
“In vitro and in cultured cells, tau binds the minor groove of the DNA double helix”
From Tau promotes neurodegeneration through global chromatin relaxation (2014) · cites this paper as [47]
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- Authors
- Sjöberg, M. K., Shestakova, E., Mansuroglu, Z., Maccioni, R. B., & Bonnefoy, E.
- Affiliations
- Laboratory of Cellular, Molecular Biology and Neurosciences, Millennium Institute for Advanced Studies in Cell Biology and Biotechnology (CBB), Faculty of Sciences, University of Chile, Las Encinas 3370, Ñuñoa, Santiago, Chile
- Centre National de la Recherche Scientifique (FR)
- University of Chile (CL)
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2006-05-15
- Volume
- 119
- Issue
- 10
- Pages
- 2025-2034
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2124201582
- Cited by
- 166
- References
- 74
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 14 · 2022: 8 · 2021: 15 · 2020: 11 · 2019: 9 · 2018: 13 · 2017: 13 · 2016: 7 · 2015: 15 · 2014: 9 · 2013: 7 · 2012: 5
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- other-oa
- Locations
- Journal of Cell Science (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Universidad de Chile (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- tau protein, nucleolus, nucleolar organization, alpha-satellite DNA, nucleolin, constitutive heterochromatin, Alzheimer's disease, Down syndrome, protein-DNA interactions
- MeSH terms
- Animals, Cell Nucleolus, DNA, Satellite, Fibroblasts, HeLa Cells, Humans, Lymphocytes, Protein Binding, tau Proteins, In Situ Hybridization, Fluorescence, Microscopy, Confocal, Electrophoretic Mobility Shift Assay, Mice
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