The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
RNA Chaperones, RNA Annealers and RNA Helicases
Open accessAbstract
RNA molecules face difficulties when folding into their native structures. In the cell, proteins can assist RNAs in reaching their functionally active states by binding and stabilizing a specific structure or, in a quite opposite way, by interacting in a non-specific manner. These proteins can either facilitate RNA-RNA interactions in a reaction termed RNA annealing, or they can resolve non-functional inhibitory structures. The latter is defined as "RNA chaperone activity" and is the main topic of this review. Here we define RNA chaperone activity in a stringent way and we review those proteins for which RNA chaperone activity has been clearly demonstrated. These proteins belong to quite diverse families such as hnRNPs, histone-like proteins, ribosomal proteins, cold shock domain proteins and viral nucleocapsid proteins. DExD/H-box containing RNA helicases are discussed as a special family of enzymes that restructure RNA or RNPs in an ATP-dependent manner. We further address the different mechanisms RNA chaperones might use to promote folding including the recently proposed theory of protein disorder as a key element in triggering RNA-protein interactions. Finally, we present a new website for proteins with RNA chaperone activity which compiles all the information on these proteins with the perspective to promote the understanding of their activity.
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Cites
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Matrix domain modulates HIV-1 Gag's nucleic acid chaperone activity via inositol phosphate binding
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Metadata
- Authors
- Rajkowitsch, L., Chen, D., Stampfl, S., Semrad, K., Waldsich, C., Mayer, O., Jantsch, M. F., Konrat, R., Bläsi, U., & Schroeder, R.
- Venue
- RNA Biology
- Publisher
- Informa UK Limited
- Published
- 2007-07
- Volume
- 4
- Issue
- 3
- Pages
- 118-130
- ISSN
- 1547-6286 (ISSN-L)
- 1555-8584
- OpenAlex
- W2032669220
- Cited by
- 332
- References
- 138
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Rajkowitsch, L., Chen, D., Stampfl, S., Semrad, K., Waldsich, C., Mayer, O., Jantsch, M. F., Konrat, R., Bläsi, U., & Schroeder, R. (2007). RNA Chaperones, RNA Annealers and RNA Helicases. RNA Biology. https://doi.org/10.4161/rna.4.3.5445
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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