The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Core protein: A pleiotropic keystone in the HBV lifecycle
Open accessAbstract
Hepatitis B Virus (HBV) is a small virus whose genome has only four open reading frames. We argue that the simplicity of the virion correlates with a complexity of functions for viral proteins. We focus on the HBV core protein (Cp), a small (183 residue) protein that self-assembles to form the viral capsid. However, its functions are a little more complicated than that. In an infected cell Cp modulates every step of the viral lifecycle. Cp is bound to nuclear viral DNA and affects its epigenetics. Cp correlates with RNA specificity. Cp assembles specifically on a reverse transcriptase-viral RNA complex or, apparently, nothing at all. Indeed Cp has been one of the model systems for investigation of virus self-assembly. Cp participates in regulation of reverse transcription. Cp signals completion of reverse transcription to support virus secretion. Cp carries both nuclear localization signals and HBV surface antigen (HBsAg) binding sites; both of these functions appear to be regulated by contents of the capsid. Cp can be targeted by antivirals -- while self-assembly is the most accessible of Cp activities, we argue that it makes sense to engage the broader spectrum of Cp function. This article forms part of a symposium in Antiviral Research on “From the discovery of the Australia antigen to the development of new curative therapies for hepatitis B: an unfinished story.”
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Cites
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The Crystal Structure of the Human Hepatitis B Virus Capsid
Wynne, S. A., Crowther, R. A., & Leslie, A. G. W. (1999) · Molecular Cell · doi:10.1016/s1097-2765(01)80009-5 · Cited by 667
Control of cccDNA function in hepatitis B virus infection
Levrero, M., Pollicino, T., Petersen, J., Belloni, L., Raimondo, G., & Dandri, M. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.05.022 · Cited by 552
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Inhibition of Hepatitis B Virus Replication by Drug-Induced Depletion of Nucleocapsids
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Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function
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Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection
Lucifora, J., Arzberger, S., Durantel, D., Belloni, L., Strubin, M., Levrero, M., Zoulim, F., Hantz, O., & Protzer, U. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.02.015 · Cited by 481
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Cited by
Chabrolles, H., Auclair, H., Vegna, S., Lahlali, T., Pons, C., Michelet, M., Couté, Y., Belmudes, L., Chadeuf, G., Kim, Y., et al. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008593 · Cited by 48
Metadata
- Authors
- Zlotnick, A., Venkatakrishnan, B., Tan, Z., Lewellyn, E., Turner, W., & Francis, S.
- Venue
- Antiviral Research
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 121
- Pages
- 82-93
- ISSN
- 0166-3542 (ISSN-L)
- OpenAlex
- W789385326
- Cited by
- 268
- References
- 117
- FWCI
- 18.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Zlotnick, A., Venkatakrishnan, B., Tan, Z., Lewellyn, E., Turner, W., & Francis, S. (2015). Core protein: A pleiotropic keystone in the HBV lifecycle. Antiviral Research. https://doi.org/10.1016/j.antiviral.2015.06.020
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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