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Cited by 51

Individual microRNAs (miRNAs) display distinct mRNA targeting “rules”

Wang, Wang-Xia, Wilfred, Bernard R., Xie, Kevin, Jennings, Mary H., Hu, Yanling, Stromberg, Arnold J., Nelson, Peter·2010·RNA Biology
DOI 10.4161/rna.7.3.11693PMC PMC3040646
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  • Members of the miR-15/107 family have overlapping mRNA targets.

    “These miRNAs have overlapping targets.”

    From Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells (2014) · cites this paper as [16]

  • Since miR-15/107 miRNAs have highly overlapping targets and multiple members are transcribed at constitutively high levels, any therapeutic or diagnostic method based on one family member must also take into account the biological activities of other family members.

    “In other words, since miR-15/107 miRNAs have highly overlapping targets [7,16,41], and multiple members of the gene family are transcribed at constitutively high levels, any therapeutic or diagnostic method based on one family member must also take into account the biological activities of other family members.”

    From Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells (2014) · cites this paper as [16]

  • Because miR-15/107 miRNAs co-exist alongside highly-expressed miRNAs with overlapping targets, it is necessary to take into account the expression and activities of paralogous miRNAs, rather than just focusing on individual miRNAs in isolation.

    “Since miR-15/107 miRNAs (like many other miRNAs that have co-evolved with paralogs) co-exist alongside highly-expressed miRNAs with overlapping targets [7,16], these data provide support to the idea that it is necessary to take into account the expression and activities of paralogous miRNAs, rather than just focusing on individual miRNAs in isolation.”

    From Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells (2014) · cites this paper as [16]

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Research works printed but not linked: 39

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Authors
Wang, W.-X., Wilfred, B. R., Xie, K., Jennings, M. H., Hu, Y., Stromberg, A. J., & Nelson, P.
Venue
RNA Biology
Publisher
Informa UK Limited
Published
2010-05
Volume
7
Issue
3
Pages
373-380
ISSN
  • 1547-6286
  • 1555-8584
DOI
10.4161/rna.7.3.11693
PMC
PMC3040646
Cited by
51
References
0
Language
en

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