MicroRNA-9: Functional evolution of a conserved small regulatory RNA
Abstract
The functional significance of microRNA-9 (miR-9) during evolution is evidenced by its conservation at the nucleotide level from flies to humans but not its diverse expression patterns. Recent studies in several model systems reveal that miR-9 can regulate neurogenesis through its actions in neural or non-neural cell lineages. In vertebrates, miR-9 exerts diverse cell-autonomous effects on the proliferation, migration, and differentiation of neural progenitor cells by modulating different mRNA targets. In some developmental contexts, miR-9 suppresses apoptosis and is misregulated in several types of cancer cells, influencing proliferation or metastasis formation. Moreover, downregulation of miR-9 in postmitotic neurons is also implicated in some neurodegenerative diseases. Thus, miR-9 is emerging as an important regulator in development and disease through its ability to modulate different targets in a manner dependent on the developmental stage and the cellular context.
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miR-9-5p and miR-9-3p are abundantly expressed in postmitotic neurons.
“However, miR-9-5p and miR-9-3p are abundantly expressed, not only in neural progenitors, but also in postmitotic neurons (Yuva-Aydemir et al., 2011;Liu et al., 2012).”
From The Brain-Enriched MicroRNA miR-9-3p Regulates Synaptic Plasticity and Memory (2016) · cites this paper as Yuva-Aydemir et al., 2011
Cites
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Regulation of miRNA expression during neural cell specification
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Regulatory networks defining EMT during cancer initiation and progression
Craene, B. D., & Berx, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3447 · Cited by 2,487 · see citing works
MicroRNAs shape the neuronal landscape
McNeill, E., & Van Vactor, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.005 · Cited by 274 · see citing works
The Brain-Enriched MicroRNA miR-9-3p Regulates Synaptic Plasticity and Memory
Sim, S.-E., Lim, C.-S., Kim, J.-I., Seo, D., Chun, H., Yu, N.-K., Lee, J., Kang, S. J., Ko, H.-G., Choi, J.-H., et al. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0630-16.2016 · Cited by 116 · see citing works
Global Transcriptome Abnormalities of the Eutopic Endometrium from Women with Adenomyosis
Herndon, C. N., Aghajanova, L., Balayan, S., Erikson, D., Barragan, F., Goldfien, G., Vo, K. C., Hawkins, S., & Giudice, L. C. (2016) · Reproductive Sciences · doi:10.1177/1933719116650758 · Cited by 106 · see citing works
Shi, S., Leites, C., He, D., Schwartz, D., Moy, W., Shi, J., & Duan, J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.535203 · Cited by 61 · see citing works
- Authors
- Yuva-Aydemir, Y., Simkin, A., Gascon, E., & Gao, F.-B.
- Venue
- RNA Biology
- Publisher
- Informa UK Limited
- Published
- 2011-07
- Volume
- 8
- Issue
- 4
- Pages
- 557-564
- ISSN
- 1547-6286
- 1555-8584
- Cited by
- 156
- References
- 5
- Language
- en
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