MicroRNAs shape the neuronal landscape
Open accessAbstract
The nervous system equips us with capability to adapt to many conditions and circumstances. We rely on an armamentarium of intricately formed neural circuits for many of our adaptive strategies. However, this capability also depends on a well-conserved toolkit of different molecular mechanisms that offer not only compensatory responses to a changing world, but also provide plasticity to achieve changes in cellular state that underlie a broad range of processes from early developmental transitions to life-long memory. Among the molecular tools that mediate changes in cellular state, our understanding of posttranscriptional regulation of gene expression is expanding rapidly. Part of the "epigenetic landscape" that shapes the deployment and robust regulation of gene networks during the construction and the remodeling of the brain is the microRNA system controlling both levels and translation of messenger RNA. Here we consider recent advances in the study of microRNA-mediated regulation of synaptic form and function.
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Microglia can secrete exosomes carrying miRNA capable of exerting acute impact upon adult neuroplasticity.
“it has been reported that microglia can secrete exosomes carrying miRNA that are capable of exerting an acute impact upon adult neuroplasticity.17,18”
From Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression (2022) · cites this paper as [17]
miR-146a-5p is a microglial-enriched miRNA that affects excitatory synapses.
“miR-146a-5p has been shown to be a microglial-enriched miRNA that affects excitatory synapses.17,18”
From Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression (2022) · cites this paper as [17]
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- Authors
- McNeill, E., & Van Vactor, D.
- Affiliations
- Harvard University (US)
- ORCID
- McNeill, Elizabeth
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 75
- Issue
- 3
- Pages
- 363-379
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3441179
- OpenAlex
- W2004390998
- Cited by
- 274
- References
- 180
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 9 · 2023: 10 · 2022: 11 · 2021: 16 · 2020: 20 · 2019: 11 · 2018: 23 · 2017: 22 · 2016: 25 · 2015: 31 · 2014: 43 · 2013: 36 · 2012: 3
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS069695, T32NS007484)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- microRNA, post-transcriptional regulation, synaptic plasticity, neuroplasticity, epigenetic regulation, mRNA translation, neural circuits, memory formation, brain development, synaptic function
- MeSH terms
- Animals, Brain, Gene Expression Regulation, Humans, Neuronal Plasticity, Neurons, MicroRNAs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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