Cited by 274MicroRNA in disease regulationNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

MicroRNAs shape the neuronal landscape

Open access
McNeill, Elizabeth, Van Vactor, David·2012·Neuron

Abstract

The nervous system equips us with capability to adapt to many conditions and circumstances. We rely on an armamentarium of intricately formed neural circuits for many of our adaptive strategies. However, this capability also depends on a well-conserved toolkit of different molecular mechanisms that offer not only compensatory responses to a changing world, but also provide plasticity to achieve changes in cellular state that underlie a broad range of processes from early developmental transitions to life-long memory. Among the molecular tools that mediate changes in cellular state, our understanding of posttranscriptional regulation of gene expression is expanding rapidly. Part of the "epigenetic landscape" that shapes the deployment and robust regulation of gene networks during the construction and the remodeling of the brain is the microRNA system controlling both levels and translation of messenger RNA. Here we consider recent advances in the study of microRNA-mediated regulation of synaptic form and function.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2012.07.005

Cites

180 of 180 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Kindler S Kreienkamp H-J Kreutz MR Sala C 2012 Synaptic Plasticity Vienna Springer Vienna 285 305

Cited by

Sorted by citations

Authors
McNeill, E., & Van Vactor, D.
Affiliations
Harvard University (US)
Venue
Neuron
Publisher
Elsevier BV
Published
2012-08
Volume
75
Issue
3
Pages
363-379
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2004390998
Cited by
274
References
180
Citations by year
2026: 8 · 2025: 6 · 2024: 9 · 2023: 10 · 2022: 11 · 2021: 16 · 2020: 20 · 2019: 11 · 2018: 23 · 2017: 22 · 2016: 25 · 2015: 31 · 2014: 43 · 2013: 36 · 2012: 3
FWCI
2.70
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS069695, T32NS007484)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
microRNA, post-transcriptional regulation, synaptic plasticity, neuroplasticity, epigenetic regulation, mRNA translation, neural circuits, memory formation, brain development, synaptic function
MeSH terms
Animals, Brain, Gene Expression Regulation, Humans, Neuronal Plasticity, Neurons, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review