The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock
Open accessAbstract
Multiple experimental and human trials have shown that microcirculatory alterations are frequent in sepsis. In this review, we discuss the various mechanisms that are potentially involved in their development and the implications of these alterations. Endothelial dysfunction, impaired inter-cell communication, altered glycocalyx, adhesion and rolling of white blood cells and platelets, and altered red blood cell deformability are the main mechanisms involved in the development of these alterations. Microcirculatory alterations increase the diffusion distance for oxygen and, due to the heterogeneity of microcirculatory perfusion in sepsis, may promote development of areas of tissue hypoxia in close vicinity to well-oxygenated zones. The severity of microvascular alterations is associated with organ dysfunction and mortality. At this stage, therapies to specifically target the microcirculation are still being investigated.
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Cites
Novel cell death program leads to neutrophil extracellular traps
Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197
Eltzschig, H. K., & Carmeliet, P. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0910283 · Cited by 2,061
Crabtree, M. J., Smith, C. L., Lam, G., Goligorsky, M. S., & Gross, S. S. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00823.2007 · Cited by 213
Cited by
Endothelial barrier dysfunction in septic shock
Opal, S. M., & van der Poll, T. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12331 · Cited by 353
Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury
Park, I., Kim, M., Choe, K., Song, E., Seo, H., Hwang, Y., Ahn, J., Lee, S.-H., Lee, J. H., Jo, Y. H., et al. (2019) · European Respiratory Journal · doi:10.1183/13993003.00786-2018 · Cited by 336
Oudemans-van Straaten, H. M., Man, A. M. S.-D., & de Waard, M. C. (2014) · Critical Care · doi:10.1186/s13054-014-0460-x · Cited by 299
Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?
Dewitte, A., Lepreux, S., Villeneuve, J., Rigothier, C., Combe, C., Ouattara, A., & Ripoche, J. (2017) · Annals of Intensive Care · doi:10.1186/s13613-017-0337-7 · Cited by 194
Kuhn, S.-O., Meissner, K., Mayes, L. M., & Bartels, K. (2018) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000549 · Cited by 82
Metadata
- Authors
- De Backer, D., Orbegozo Cortes, D., Donadello, K., & Vincent, J.-L.
- Venue
- Virulence
- Publisher
- Informa UK Limited
- Published
- 2013-09-25
- Volume
- 5
- Issue
- 1
- Pages
- 73-79
- ISSN
- 2150-5594 (ISSN-L)
- 2150-5608
- OpenAlex
- W1995485815
- Cited by
- 393
- References
- 3
- FWCI
- 17.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- De Backer, D., Orbegozo Cortes, D., Donadello, K., & Vincent, J.-L. (2014). Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock. Virulence. https://doi.org/10.4161/viru.26482
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