Vitamin C in sepsis
Open accessAbstract
PURPOSE OF REVIEW: This narrative review summarizes recent insights into the role of vitamin C in sepsis. RECENT FINDINGS: Septic shock remains a major source of morbidity and mortality in critically ill patients. Although many nutritional supplements have previously been tested unsuccessfully, vitamins are still being explored as a therapeutic option in septic patients. In particular, vitamin C-containing regimens as adjunctive therapy in sepsis have received much attention. SUMMARY: In-vitro evidence supports a critical role for vitamin C in cellular mechanisms relevant to the pathophysiology of sepsis. However, whether this justifies therapeutic use of vitamin C in septic patients remains uncertain.
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LUNGSAFE reported that plateau pressure correlated with mortality; however, the relationship between the two was not evident when plateau pressure was below 20 cm H2O.
“LUNGSAFE, a large international observational study, which reported that plateau pressure correlated with mortality; however, the relationship between the two was not evident when plateau pressure was below 20 cm H 2 O (435).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [435]
The Introduction discusses sepsis mortality, but not the LUNGSAFE study or ventilator plateau pressure. Searches of our copy for LUNGSAFE, plateau pressure, and the 20 cm H2O threshold found no passage addressing the claimed mortality relationship; the retrieved passages have no page numbers. (LLM, conf=0.76)
Experimental — accuracy not yet measuredVitamin C is known to have anti-inflammatory properties.
“Vitamin C is known to have anti-inflammatory properties [520].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [520]
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- [67]Tanaka H Reduction of Resuscitation Fluid Volumes in Severely Burned Patients Using Ascorbic Acid Administration Arch Surg 2000 135 326 31 10722036
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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
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- Authors
- Kuhn, S.-O., Meissner, K., Mayes, L. M., & Bartels, K.
- Affiliations
- Universitätsmedizin Greifswald (DE)
- University of Colorado Anschutz (US)
- Corresponding author
- Bartels, Karsten
- Venue
- Current Opinion in Anaesthesiology
- Published
- 2018-02
- Volume
- 31
- Issue
- 1
- Pages
- 55-60
- ISSN
- 0952-7907 (ISSN-L)
- PMC
- PMC5996765
- OpenAlex
- W2769196701
- Cited by
- 82
- References
- 75
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 13 · 2022: 19 · 2021: 24 · 2020: 9 · 2019: 6 · 2018: 1
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Current Opinion in Anaesthesiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (K23DA040923)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- vitamin C, sepsis, septic shock, adjunctive therapy, dietary supplements, vitamin therapy, sepsis pathophysiology, critically ill patients
- MeSH terms
- Ascorbic Acid, Humans, Critical Illness, Sepsis
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