Cited by 2,022Cell Adhesion Molecules ResearchAngiogenesis and VEGF in CancerNitric Oxide and Endothelin Effects

Evolving functions of endothelial cells in inflammation

Pober, Jordan S., Sessa, William C.·2007·Nature Reviews Immunology

Abstract

Inflammation is usually analysed from the perspective of tissue-infiltrating leukocytes. Microvascular endothelial cells at a site of inflammation are both active participants in and regulators of inflammatory processes. The properties of endothelial cells change during the transition from acute to chronic inflammation and during the transition from innate to adaptive immunity. Mediators that act on endothelial cells also act on leukocytes and vice versa. Consequently, many anti-inflammatory therapies influence the behaviour of endothelial cells and vascular therapeutics influence inflammation. This Review describes the functions performed by endothelial cells at each stage of the inflammatory process, emphasizing the principal mediators and signalling pathways involved and the therapeutic implications.

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Crossref · 10.1038/nri2171

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  • A burst in the generation of proinflammatory agents contributes to endothelial barrier breakdown in sepsis, ARDS, dengue fever, and malaria, promoting shock and multiorgan failure in patients.

    “A burst in the generation of proinflammatory agents, as a part of an overwhelmed host response, contributes to endothelial barrier breakdown in these diseases, promoting shock and multiorgan failure in patients (1, 2).”
  • Immune functions are not unique to hematopoietic cells; many other cell types display basic mechanisms of pathogen defence.

    “However, immune functions are not unique to hematopoietic cells, and many other cell types display basic mechanisms of pathogen defence3–5.”

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Authors
Pober, J. S., & Sessa, W. C.
Affiliations
Yale University (US)
Corresponding author
Pober, Jordan S.
Venue
Nature Reviews Immunology
Published
2007-10
Volume
7
Issue
10
Pages
803-815
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2171783221
Cited by
2,022
References
99
Citations by year
2026: 147 · 2025: 138 · 2024: 163 · 2023: 138 · 2022: 185 · 2021: 194 · 2020: 151 · 2019: 100 · 2018: 104 · 2017: 120 · 2016: 75 · 2015: 100 · 2014: 78 · 2013: 74 · 2012: 77
FWCI
3.57
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
endothelial cells, inflammation, acute and chronic inflammation, leukocyte-endothelium interaction, vascular inflammation, anti-inflammatory therapy, inflammatory mediators
MeSH terms
Animals, Anti-Inflammatory Agents, Communicable Diseases, Histamine, Humans, Inflammation, Wounds and Injuries, Signal Transduction, Cytokines, Endothelial Cells

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