Evolving functions of endothelial cells in inflammation
Abstract
Inflammation is usually analysed from the perspective of tissue-infiltrating leukocytes. Microvascular endothelial cells at a site of inflammation are both active participants in and regulators of inflammatory processes. The properties of endothelial cells change during the transition from acute to chronic inflammation and during the transition from innate to adaptive immunity. Mediators that act on endothelial cells also act on leukocytes and vice versa. Consequently, many anti-inflammatory therapies influence the behaviour of endothelial cells and vascular therapeutics influence inflammation. This Review describes the functions performed by endothelial cells at each stage of the inflammatory process, emphasizing the principal mediators and signalling pathways involved and the therapeutic implications.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A burst in the generation of proinflammatory agents contributes to endothelial barrier breakdown in sepsis, ARDS, dengue fever, and malaria, promoting shock and multiorgan failure in patients.
“A burst in the generation of proinflammatory agents, as a part of an overwhelmed host response, contributes to endothelial barrier breakdown in these diseases, promoting shock and multiorgan failure in patients (1, 2).”
From Targeting β1-integrin inhibits vascular leakage in endotoxemia (2018) · cites this paper as [1]
Immune functions are not unique to hematopoietic cells; many other cell types display basic mechanisms of pathogen defence.
“However, immune functions are not unique to hematopoietic cells, and many other cell types display basic mechanisms of pathogen defence3–5.”
From Structural cells are key regulators of organ-specific immune responses (2020) · cites this paper as [4]
Cites
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064 · see citing works
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738 · see citing works
The immune response in atherosclerosis: a double-edged sword
Hansson, G. K., & Libby, P. (2006) · Nature reviews. Immunology · doi:10.1038/nri1882 · Cited by 2,176 · see citing works
Caterina, R. D., Libby, P., Peng, H., Thannickal, V. J., Rajavashisth, T. B., Gimbrone, M. A., Shin, W. S., & Liao, J. K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118074 · Cited by 1,781 · see citing works
Phenotypic Heterogeneity of the Endothelium
Aird, W. C. (2007) · Circulation Research · doi:10.1161/01.res.0000255691.76142.4a · Cited by 1,744 · see citing works
Dvorak, H. F. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.10.088 · Cited by 1,574 · see citing works
Endothelial Cell-to-Cell Junctions: Molecular Organization and Role in Vascular Homeostasis
Bazzoni, G., & Dejana, E. (2004) · Physiological Reviews · doi:10.1152/physrev.00035.2003 · Cited by 1,384 · see citing works
Angiopoietin-1 protects the adult vasculature against plasma leakage
Thurston, G., Rudge, J. S., Ioffe, E., Zhou, H., Ross, L. H., Croll, S. D., Glazer, N. L., Holash, J. A., McDonald, D. M., & Yancopoulos, G. D. (2000) · Nature Medicine · doi:10.1038/74725 · Cited by 1,284 · see citing works
Phenotypic Heterogeneity of the Endothelium
Aird, W. C. (2007) · Circulation Research · doi:10.1161/01.res.0000255690.03436.ae · Cited by 1,252 · see citing works
Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
Shibuya, M., & Claesson, L. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.11.012 · Cited by 1,063 · see citing works
Bevilacqua, M. P., Pober, J. S., Majeau, G. R., Fiers, W. C., Cotran, R. S., & Gimbrone, M. A. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4533 · Cited by 1,059 · see citing works
Self-citationLuster, A. D., Unkeless, J. C., & Ravetch, J. V. (1985) · Nature · doi:10.1038/315672a0 · Cited by 944 · see citing works
Fiedler, U., Reiss, Y., Scharpfenecker, M., Grunow, V., Koidl, S., Thurston, G., Gale, N. W., Witzenrath, M., Rosseau, S., Suttorp, N., et al. (2006) · Nature Medicine · doi:10.1038/nm1351 · Cited by 933 · see citing works
DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS
Gainetdinov, R. R., Premont, R. T., Bohn, L., Lefkowitz, R. J., & Caron, M. G. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144206 · Cited by 864 · see citing works
Clauss, M. A., Gerlach, M. L., Gerlach, H., Brett, J., Wang, F., Familletti, P. C., Pan, Y.-C. E., Olander, J. V., Connolly, D. T., & Stern, D. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1535 · Cited by 831 · see citing works
THE ROLE OF ENDOTHELIAL CELLS IN INFLAMMATION
Pober, J. S., & Cotran, R. S. (1990) · Transplantation · doi:10.1097/00007890-199010000-00001 · Cited by 813 · see citing works
Self-citationLymphoid organ development: from ontogeny to neogenesis
Drayton, D. L., Liao, S., Mounzer, R. H., & Ruddle, N. H. (2006) · Nature Immunology · doi:10.1038/ni1330 · Cited by 777 · see citing works
Yoshizumi, M., Perrella, M. A., Burnett, J. C., & Lee, M. E. (1993) · Circulation Research · doi:10.1161/01.res.73.1.205 · Cited by 771 · see citing works
Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells
Middleton, J., Neil, S. J. D., Wintle, J., Clark‐Lewis, I., Moore, H. D., Lam, C., Auer, M., Hub, E., & Rot, A. (1997) · Cell · doi:10.1016/s0092-8674(00)80422-5 · Cited by 729 · see citing works
P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues
Austrup, F., Vestweber, D., Borges, E., Löhning, M., Bräuer, R., Herz, U., Renz, H. E., Hallmann, R., Scheffold, A., Radbruch, A., et al. (1997) · Nature · doi:10.1038/385081a0 · Cited by 723 · see citing works
Apoptotic Vascular Endothelial Cells Become Procoagulant
Bombeli, T., Karsan, A., Tait, J. F., & Harlan, J. M. (1997) · Blood · doi:10.1182/blood.v89.7.2429 · Cited by 623 · see citing works
Angiopoietins: a link between angiogenesis and inflammation
Fiedler, U., & Augustin, H. G. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.10.004 · Cited by 606 · see citing works
Lee, C. G., Link, H., Bałuk, P., Homer, R., Chapoval, S. P., Bhandari, V., Kang, M., Cohn, L. E., Kim, Y. K., McDonald, D. M., et al. (2004) · Nature Medicine · doi:10.1038/nm1105 · Cited by 586 · see citing works
NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling
Kreuz, S., Siegmund, D., Scheurich, P., & Wajant, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.3964-3973.2001 · Cited by 579 · see citing works
Lorant, D. E., Patel, K. D., McIntyre, T. M., McEver, R. P., Prescott, S. M., & Zimmerman, G. A. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.1.223 · Cited by 576 · see citing works
Inhibitors of NF-κB signaling: 785 and counting
Gilmore, T. D., & Herscovitch, M. (2006) · Oncogene · doi:10.1038/sj.onc.1209982 · Cited by 571 · see citing works
Sessa, W. C. (2004) · Journal of Cell Science · doi:10.1242/jcs.01165 · Cited by 561 · see citing works
Self-citationBerg, E. L., Yoshino, T., Rott, L. S., Robinson, M. K., Warnock, R. A., Kishimoto, T., Picker, L. J., & Butcher, E. C. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.6.1461 · Cited by 548 · see citing works
PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells
Bonfanti, R., Furie, B., Furie, B., & Wagner, D. D. (1989) · Blood · doi:10.1182/blood.v73.5.1109.1109 · Cited by 546 · see citing works
CD99 plays a major role in the migration of monocytes through endothelial junctions
Schenkel, A. R., Mamdouh, Z., Chen, X., Liebman, R. M., & Müller, W. A. (2002) · Nature Immunology · doi:10.1038/ni749 · Cited by 507 · see citing works
Transcellular Diapedesis Is Initiated by Invasive Podosomes
Carman, C. V., Sage, P. T., Sciuto, T. E., de la Fuente, M. Á., Geha, R. S., Ochs, H. D., Dvorak, H. F., Dvořàk, A. M., & Springer, T. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.015 · Cited by 497 · see citing works
Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor
Matsushita, K., Morrell, C. N., Cambien, B., Yang, S.-X., Yamakuchi, M., Bao, C., Hara, M. R., Quick, R. A., Cao, W., O'Rourke, B. P., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00803-1 · Cited by 446 · see citing works
Role of Angiogenesis in Cardiovascular Disease
Khurana, R., Simons, M., Martin, J. F., & Zachary, I. C. (2005) · Circulation · doi:10.1161/circulationaha.105.535294 · Cited by 445 · see citing works
Prescott, S. M., Zimmerman, G. A., & McIntyre, T. M. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.11.3534 · Cited by 435 · see citing works
Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family
Martin, M. U., & Wesche, H. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00320-8 · Cited by 426 · see citing works
Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+-permeable channel
Lückhoff, A., & Clapham, D. E. (1992) · Nature · doi:10.1038/355356a0 · Cited by 417 · see citing works
CXC chemokines in angiogenesis
Strieter, R. M., Burdick, M. D., Gomperts, B. N., Belperio, J. A., & Keane, M. P. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.04.007 · Cited by 416 · see citing works
Pober, J. S., Lapierre, L. A., Stolpen, A. H., Brock, T. A., Springer, T. A., Fiers, W. C., Bevilacqua, M. P., Mendrick, D. L., & Gimbrone, M. A. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.10.3319 · Cited by 415 · see citing works
Self-citationNeutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP
Feng, D., Nagy, J. A., Pyne, K., Dvorak, H. F., & Dvořàk, A. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.6.903 · Cited by 412 · see citing works
Nitric Oxide and the Vascular Endothelium
Moncada, S., & Higgs, E. A. (2006) · Springer eBooks · doi:10.1007/3-540-32967-6_7 · Cited by 408 · see citing works
Cyclooxygenase-2: Regulation and relevance in inflammation
Mitchell, J. A., Larkin, S. W., & Williams, T. J. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00212-x · Cited by 375 · see citing works
Angiogenesis in rheumatoid arthritis.
Paleolog, E. M. (2002) · Arthritis Research · doi:10.1186/ar575 · Cited by 354 · see citing works
Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell death
Bhandari, V., Choo-Wing, R., Lee, C. G., Zhu, Z., Nedrelow, J. H., Chupp, G. L., Zhang, X., Matthay, M. A., Ware, L. B., Homer, R., et al. (2006) · Nature Medicine · doi:10.1038/nm1494 · Cited by 337 · see citing works
Munro, J. M., Pober, J. S., & Cotran, R. S. (1989) · PubMed · Cited by 332 · see citing works
Self-citationCoughlin, C. M., Salhany, K. E., Gee, M. S., LaTemple, D. C., Kotenko, S. V., Ma, X., Gri, G., Wysocka, M., Kim, J. E., Liu, L., et al. (1998) · Immunity · doi:10.1016/s1074-7613(00)80585-3 · Cited by 324 · see citing works
The Role of the Microtubules in Tumor Necrosis Factor-α–Induced Endothelial Cell Permeability
Petrache, I., Birukova, A. A., Ramirez, S. I., Garcia, J. G. N., & Verin, A. D. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2002-0075oc · Cited by 322 · see citing works
Caveolae and Caveolins in the Cardiovascular System
Gratton, J., Bernatchez, P. N., & Sessa, W. C. (2004) · Circulation Research · doi:10.1161/01.res.0000129178.56294.17 · Cited by 317 · see citing works
Self-citationHirahara, K., Liu, L., Clark, R. A., Yamanaka, K., Fuhlbrigge, R. C., & Kupper, T. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4488 · Cited by 292 · see citing works
Proinflammatory functions of vascular endothelial growth factor in alloimmunity
Reinders, M. E. J., Sho, M., Izawa, A., Wang, P., Mukhopadhyay, D., Koss, K. E., Geehan, C. S., Luster, A. D., Sayegh, M. H., & Briscoe, D. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17712 · Cited by 251 · see citing works
Mechanisms regulating endothelial cell barrier function
Stevens, T., Garcia, J. G. N., Shasby, D. M., Bhattacharya, J., & Malik, A. B. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.3.l419 · Cited by 248 · see citing works
Briscoe, D. M., Cotran, R. S., & Pober, J. S. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.9.2954 · Cited by 230 · see citing works
Self-citationMadge, L. A., & Pober, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001237200 · Cited by 205 · see citing works
Self-citationRole of Cyclooxygenases in Angiogenesis
Leahy, K., Koki, A. T., & Masferrer, J. L. (2000) · Current Medicinal Chemistry · doi:10.2174/0929867003374336 · Cited by 198 · see citing works
T L ymphocyte –E ndothelial C ell I nteractions
Choi, J., Enis, D. R., Koh, K. P., Shiao, S. L., & Pober, J. S. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104639 · Cited by 194 · see citing works
Self-citationTHE SITE OF LEUCOCYTE EMIGRATION DURING INFLAMMATION
Marchesi, V. (1961) · Quarterly Journal of Experimental Physiology and Cognate Medical Sciences · doi:10.1113/expphysiol.1961.sp001522 · Cited by 190 · see citing works
Targeting the Inflammatory Response in Healing Myocardial Infarcts
Frangogiannis, N. G. (2006) · Current Medicinal Chemistry · doi:10.2174/092986706777585086 · Cited by 190 · see citing works
Synchrony of High Endothelial Venules and Lymphatic Vessels Revealed by Immunization
Liao, S., & Ruddle, N. H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.3369 · Cited by 180 · see citing works
Feng, D., Nagy, J. A., Pyne, K., Hammel, I., Dvorak, H. F., & Dvořàk, A. M. (1999) · Microcirculation · doi:10.1111/j.1549-8719.1999.tb00085.x · Cited by 175 · see citing works
IFN-gamma enhances endothelial activation induced by tumor necrosis factor but not IL-1.
Doukas, J., & Pober, J. S. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.6.1727 · Cited by 172 · see citing works
Self-citationZhang, R., Xu, Y., Ekman, N., Wu, Z., Wu, J., Alitalo, K. K., & Wang, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310678200 · Cited by 163 · see citing works
Heltianu, C., Simionescu, M., & Simionescu, N. (1982) · The Journal of Cell Biology · doi:10.1083/jcb.93.2.357 · Cited by 157 · see citing works
Al‐Lamki, R. S., Wang, J., Vandenabeele, P., Bradley, J. A., Thiru, S., Luo, D., Wang, M., Pober, J. S., & Bradley, J. R. (2005) · The FASEB Journal · doi:10.1096/fj.05-3841com · Cited by 146 · see citing works
Self-citationSadeghi, M. M., Collinge, M., Pardi, R., & Bender, J. R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.5.2712 · Cited by 144 · see citing works
LOCALIZATION OF HLA-ABC AND DR ANTIGENS IN HUMAN KIDNEY
Hart, D. N. J., Fuggle, S. V., WILLIAMS, K. A., Fabre, J. W., Ting, A., & Morris, P. J. (1981) · Transplantation · doi:10.1097/00007890-198106000-00005 · Cited by 142 · see citing works
Initiation and pattern of angiogenesis in wound healing in the rat
Phillips, G. D., Whitehead, R. A., & Knighton, D. R. (1991) · American Journal of Anatomy · doi:10.1002/aja.1001920305 · Cited by 141 · see citing works
Monaco, C. G., Andreakos, E., Kiriakidis, S., Feldmann, M., & Paleolog, E. M. (2004) · Current Drug Targets - Inflammation & Allergy · doi:10.2174/1568010043483881 · Cited by 138 · see citing works
Transport Across the Endothelium: Regulation of Endothelial Permeability
Minshall, R. D., & Malik, A. B. (2006) · Springer eBooks · doi:10.1007/3-540-32967-6_4 · Cited by 135 · see citing works
Kuhlencordt, P. J., Rosel, E. A., Gerszten, R. E., Morales‐Ruiz, M., Dombkowski, D., Atkinson, W. J., Han, F., Preffer, F. I., Rosenzweig, A., Sessa, W. C., et al. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00546.2002 · Cited by 129 · see citing works
Self-citationClark, P. R., Manes, T. D., Pober, J. S., & Kluger, M. S. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700670 · Cited by 122 · see citing works
Self-citationG Protein βγ Subunits Stimulate p114RhoGEF, a Guanine Nucleotide Exchange Factor for RhoA and Rac1
Niu, J., Profirovic, J., Pan, H., Vaiškunaite, R., & Voyno-Yasenetskaya, T. (2003) · Circulation Research · doi:10.1161/01.res.0000097607.14733.0c · Cited by 120 · see citing works
Review of Trials in Chronic Heart Failure Showing Broad-Spectrum Anti-Inflammatory Approaches
Gullestad, L. L., & Aukrust, P. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.03.008 · Cited by 119 · see citing works
Angiopoietin‐1 negatively regulates expression and activity of tissue factor in endothelial cells
Kim, I., Oh, J., Ryu, Y. S., So, J.-N., Sessa, W. C., Walsh, K., & Koh, G. Y. (2001) · The FASEB Journal · doi:10.1096/fj.01-0556fje · Cited by 115 · see citing works
Self-citationKarmann, K., Min, W., Fanslow, W. C., & Pober, J. S. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.1.173 · Cited by 114 · see citing works
Self-citationMemory T Cells and Their Costimulators in Human Allograft Injury
Shiao, S. L., McNiff, J. M., & Pober, J. S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.4886 · Cited by 110 · see citing works
Self-citationSohn, R. H., Deming, C., Johns, D. C., Champion, H. C., Bian, C., Gardner, K. L., & Rade, J. J. (2005) · Blood · doi:10.1182/blood-2004-03-0928 · Cited by 110 · see citing works
Pan, J., Xia, L., & McEver, R. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.10058 · Cited by 108 · see citing works
Role of prostaglandins and nitric oxide in acute inflammatory reactions in guinea‐pig skin
Teixeira, M. M., Williams, T. J., & Hellewell, P. G. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13994.x · Cited by 108 · see citing works
Feng, D., Nagy, J. A., Pyne, K., Hammel, I., Dvorak, H. F., & Dvořàk, A. M. (1999) · Microcirculation · doi:10.1080/713773925 · Cited by 107 · see citing works
Vascular Endothelium and Blood Flow
Busse, R., & Fleming, I. (2006) · Springer eBooks · doi:10.1007/3-540-36028-x_2 · Cited by 104 · see citing works
Leucocyte-Endothelial Interactions in Health and Disease
Ley, K. F., & Reutershan, J. (2006) · Springer eBooks · doi:10.1007/3-540-36028-x_4 · Cited by 100 · see citing works
Cardiovascular hazard and non-steroidal anti-inflammatory drugs
Wong, D., Wang, M., Cheng, Y., & FitzGerald, G. A. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.02.001 · Cited by 95 · see citing works
Wang, J., Al‐Lamki, R. S., Zhang, H., Kirkiles-Smith, N. C., Gaeta, M. L., Thiru, S., Pober, J. S., & Bradley, J. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212662200 · Cited by 88 · see citing works
Self-citationBirch, K. A., Pober, J. S., Zavoico, G. B., Means, A. R., & Ewenstein, B. M. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.6.1501 · Cited by 87 · see citing works
Self-citationQin, L., Zhao, D., Liu, X., Nagy, J. A., Hoang, M. V., Brown, L. F., Dvorak, H. F., & Zeng, H. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-06-0126 · Cited by 83 · see citing works
Zavoico, G. B., Ewenstein, B. M., Schafer, A. I., & Pober, J. S. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.11.3993 · Cited by 80 · see citing works
Self-citationBoulday, G., Hašková, Z., Reinders, M. E. J., Pal, S., & Briscoe, D. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.5.3098 · Cited by 72 · see citing works
The Cathepsin B Death Pathway Contributes to TNF Plus IFN-γ-Mediated Human Endothelial Injury
Li, J. H., & Pober, J. S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1858 · Cited by 71 · see citing works
Self-citationImproved Lymphocyte Function-associated Antigen-1 (LFA-1) Inhibition by Statin Derivatives
Weitz‐Schmidt, G., Welzenbach, K., Dawson, J., & Kallen, J. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407951200 · Cited by 67 · see citing works
Li, J. H., Kluger, M. S., Madge, L. A., Lian, Z., Bothwell, A. L. M., & Pober, J. S. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64424-0 · Cited by 64 · see citing works
Self-citationRanjbaran, H., Wang, Y., Manes, T. D., Yakimov, A. O., Akhtar, S., Kluger, M. S., Pober, J. S., & Tellides, G. (2006) · Circulation · doi:10.1161/circulationaha.106.631457 · Cited by 62 · see citing works
Self-citationHancock, W. W., Kraft, N., & Atkins, R. C. (1982) · Pathology · doi:10.3109/00313028209092120 · Cited by 61 · see citing works
Vascular Endothelium Does Not Activate CD4+ Direct Allorecognition in Graft Rejection
Kreisel, D., Krasinskas, A. M., Krupnick, A. S., Gelman, A. E., Balsara, K. R., Popma, S. H., Riha, M., Rosengard, A. M., Turka, L. A., & Rosengard, B. R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.5.3027 · Cited by 58 · see citing works
Capillary leakage in inflammation. A study by vascular labeling.
Joris, I., Cuénoud, H., Doern, G. V., Underwood, J. M., & Majno, G. (1990) · Europe PMC (PubMed Central) · Cited by 57 · see citing works
Natalizumab and the role of α4-integrin antagonism in the treatment of multiple sclerosis
O'Connor, P. W. (2006) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.7.1.123 · Cited by 52 · see citing works
Birch, K. A., Ewenstein, B. M., Golan, D. E., & Pober, J. S. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041600318 · Cited by 49 · see citing works
Self-citationEicosanoids and the Vascular Endothelium
Egan, K. M., & FitzGerald, G. A. (2006) · Springer eBooks · doi:10.1007/3-540-32967-6_6 · Cited by 48 · see citing works
Sessa, W. C. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)01985-2 · Cited by 38 · see citing works
Self-citationResolution of inflammation: Intracellular feedback loops in the endothelium
Winsauer, G., & de Martin, R. (2007) · Thrombosis and Haemostasis · doi:10.1160/th06-08-0473 · Cited by 37 · see citing works
Cell Cooperation in Development of Eosinophil-Predominant Inflammation in Airways
Chaplin, D. (2002) · Immunologic Research · doi:10.1385/ir:26:1-3:055 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Origin and physiological roles of inflammation
Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618 · see citing works
Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis
Gimbrone, M. A., & García‐Cardeña, G. (2016) · Circulation Research · doi:10.1161/circresaha.115.306301 · Cited by 3,554 · see citing works
Inflammation and tumor progression: signaling pathways and targeted intervention
Zhao, H., Wu, L., Yan, G., Chen, Y., Zhou, M., Wu, Y., & Li, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00658-5 · Cited by 2,907 · see citing works
Cells of the adult human heart
Litviňuková, M., Talavera-López, C., Maatz, H., Reichart, D., Worth, C. L., Lindberg, E. L., Kanda, M., Polanski, K., Heinig, M., Lee, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2797-4 · Cited by 1,729 · see citing works
Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure
Boomer, J. S., To, K. B., Chang, K. C., Takasu, O., Osborne, D. F., Walton, A. H., Bricker, T. L., Jarman, S. D., Kreisel, D., Krupnick, A. S., et al. (2011) · JAMA · doi:10.1001/jama.2011.1829 · Cited by 1,789 · see citing works
Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280 · see citing works
Leukocyte Migration into Inflamed Tissues
Nourshargh, S., & Alon, R. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.008 · Cited by 1,172 · see citing works
Pathophysiology of Atherosclerosis
Jebari‐Benslaiman, S., Galicia-García, U., Larrea, A., Olaetxea, J. R., Alloza, I., Vandenbroeck, K., Benito‐Vicente, A., & Martı́n, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063346 · Cited by 1,078 · see citing works
COVID-19: the vasculature unleashed
Teuwen, L.-A. M. N., Geldhof, V., Pasut, A., & Carmeliet, P. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0343-0 · Cited by 1,010 · see citing works
Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis
Koupenova, M., Clancy, L., Corkrey, H. A., & Freedman, J. E. (2018) · Circulation Research · doi:10.1161/circresaha.117.310795 · Cited by 997 · see citing works
COVID-19 is, in the end, an endothelial disease
Libby, P., & Lüscher, T. F. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa623 · Cited by 960 · see citing works
Seldin, M. M., Meng, Y., Qi, H., Zhu, W., Wang, Z., Hazen, S. L., Lusis, A. J., & Shih, D. M. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.115.002767 · Cited by 911 · see citing works
DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation
Zindel, J., & Kubes, P. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032847 · Cited by 874 · see citing works
Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming
Tian, L., Goldstein, A., Wang, H., Ching Lo, H., Sun Kim, I., Welte, T., Sheng, K., Dobrolecki, L. E., Zhang, X., Putluri, N., et al. (2017) · Nature · doi:10.1038/nature21724 · Cited by 841 · see citing works
Immunity, inflammation and cancer: a leading role for adenosine
Antonioli, L., Blandizzi, C., Pacher, P., & Haskó, G. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3613 · Cited by 765 · see citing works
Angiotensin II revisited: new roles in inflammation, immunology and aging
Benigni, A., Cassis, P., & Remuzzi, G. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000080 · Cited by 757 · see citing works
The spectrum of inflammatory responses
Medzhitov, R. (2021) · Science · doi:10.1126/science.abi5200 · Cited by 718 · see citing works
Endothelial cell control of thrombosis
Yau, J. W., Teoh, H., & Verma, S. (2015) · BMC Cardiovascular Disorders · doi:10.1186/s12872-015-0124-z · Cited by 693 · see citing works
Toll-like receptors in immunity and inflammatory diseases: Past, present, and future
Kumar, V. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.03.002 · Cited by 649 · see citing works
Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways
Komarova, Y. A., & Malik, A. B. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135833 · Cited by 640 · see citing works
Medina-Leyte, D. J., Zepeda-García, Ó., Domínguez‐Pérez, M., González-Garrido, A., Villarreal-Molina, M. T., & Jacobo‐Albavera, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083850 · Cited by 629 · see citing works
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
Dahlman, J. E., Barnes, C., Khan, O. F., Thiriot, A., Jhunjhunwala, S., Shaw, T. E., Xing, Y., Sager, H. B., Sahay, G., Speciner, L., et al. (2014) · Nature Nanotechnology · doi:10.1038/nnano.2014.84 · Cited by 593 · see citing works
Endothelium—role in regulation of coagulation and inflammation
van Hinsbergh, V. W. M. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0285-5 · Cited by 594 · see citing works
The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System
Daryabor, G., Atashzar, M. R., Kabelitz, D., Meri, S., & Kalantar, K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01582 · Cited by 600 · see citing works
Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity
Xanthos, D. N., & Sandkühler, J. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3617 · Cited by 580 · see citing works
Emerging concepts in sporadic cerebral amyloid angiopathy
Charidimou, A., Boulouis, G., Gurol, M. E., Ayata, C., Bacskai, B. J., Frosch, M. P., Viswanathan, A., & Greenberg, S. M. (2017) · Brain · doi:10.1093/brain/awx047 · Cited by 555 · see citing works
Immunomodulation by endothelial cells — partnering up with the immune system?
Amersfoort, J., Eelen, G., & Carmeliet, P. (2022) · Nature reviews. Immunology · doi:10.1038/s41577-022-00694-4 · Cited by 549 · see citing works
Single-cell analysis reveals T cell infiltration in old neurogenic niches
Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1362-5 · Cited by 521 · see citing works
The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection
Pons, S., Fodil, S., Azoulay, É., & Zafrani, L. (2020) · Critical Care · doi:10.1186/s13054-020-03062-7 · Cited by 518 · see citing works
NF-κB in inflammation and cancer
Mao, H., Zhao, X., & Sun, S. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01310-w · Cited by 577 · see citing works
Endothelium structure and function in kidney health and disease
Jourde‐Chiche, N., Fakhouri, F., Dou, L., Bellien, J., Burtey, S., Frimat, M., Jarrot, P., Kaplanski, G., Quintrec, M. L., Pernin, V., et al. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0098-z · Cited by 499 · see citing works
NLRP3 inflammasome in endothelial dysfunction
Bai, B., Yang, Y., Wang, Q., Li, M., Tian, C., Liu, Y., Aung, L. H. H., Li, P., Yu, T., & Chu, X. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02985-x · Cited by 492 · see citing works
Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis
Suárez, Y., Fernandez-Hernando, C. F., Yu, J., Gerber, S. A., Harrison, K. D., Pober, J. S., Iruela‐Arispe, M. L., Merkenschlager, M., & Sessa, W. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804597105 · Cited by 486 · see citing works
Self-citationCytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets
Ramji, D. P., & Davies, T. S. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.04.003 · Cited by 469 · see citing works
Essential Oils: Chemistry and Pharmacological Activities
de Sousa, D. P., Damasceno, R. O. S., Amorati, R., Elshabrawy, H. A., de Castro, R. D., Bezerra, D. P., Nunes, V. R. V., Gomes, R. C., & Lima, T. C. (2023) · Biomolecules · doi:10.3390/biom13071144 · Cited by 468 · see citing works
Molecular Biology of Atherosclerosis
Hopkins, P. N. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2012 · Cited by 456 · see citing works
MicroRNA-181b regulates NF-κB–mediated vascular inflammation
Sun, X., Icli, B., Wara, A. K., Belkin, N., He, S., Kobzik, L., Hunninghake, G. M., Pinilla-Vera, M., Blackwell, T. S., Baron, R. M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61495 · Cited by 450 · see citing works
Structural cells are key regulators of organ-specific immune responses
Krausgruber, T., Fortelny, N., Fife-Gernedl, V., Senekowitsch, M., Schuster, L. C., Lercher, A., Nemc, A., Schmidl, C., Rendeiro, A. F., Bergthaler, A., et al. (2020) · Nature · doi:10.1038/s41586-020-2424-4 · Cited by 434 · see citing works
MicroRNA‐146 represses endothelial activation by inhibiting pro‐inflammatory pathways
Cheng, H. S., Sivachandran, N., Lau, A. C., Boudreau, É., Zhao, J. L., Baltimore, D., Delgado-Olguı́n, P., Cybulsky, M. I., & Fish, J. E. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202318 · Cited by 418 · see citing works
MicroRNAs As Novel Regulators of Angiogenesis
Suárez, Y., & Sessa, W. C. (2009) · Circulation Research · doi:10.1161/circresaha.108.191270 · Cited by 411 · see citing works
Self-citationThrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
Gu, S. X., Tyagi, T., Jain, K., Gu, V. W., Lee, S. H., Hwa, J. M., Kwan, J. M., Krause, D. S., Lee, A. I., Halene, S., et al. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00469-1 · Cited by 414 · see citing works
Immune mechanisms in medium and large-vessel vasculitis
Weyand, C. M., & Goronzy, J. J. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.161 · Cited by 412 · see citing works
Advances in nanomaterial-based targeted drug delivery systems
Cheng, X., Xie, Q., & Sun, Y. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1177151 · Cited by 419 · see citing works
Jin, Y., Ji, W., Yang, H., Chen, S., Zhang, W., & Duan, G. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00454-7 · Cited by 398 · see citing works
Huinen, Z. R., Huijbers, E. J. M., B, J. R. V. B., Nowak-Sliwinska, P. M., & Griffioen, A. W. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00496-y · Cited by 398 · see citing works
PECAM-1: regulator of endothelial junctional integrity
Privratsky, J. R., & Newman, P. J. (2014) · Cell and Tissue Research · doi:10.1007/s00441-013-1779-3 · Cited by 369 · see citing works
Wang, Q., Ren, Y., Mu, J., Egilmez, N. K., Zhuang, X., Deng, Z., Zhang, L., Yan, J., Miller, D. M., & Zhang, H. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3095 · Cited by 368 · see citing works
Tissue homeostasis and inflammation
Meizlish, M. L., Franklin, R. A., Zhou, X., & Medzhitov, R. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-061020-053734 · Cited by 364 · see citing works
Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies
Singh, N. K., & Rao, G. N. (2018) · Progress in Lipid Research · doi:10.1016/j.plipres.2018.11.001 · Cited by 348 · see citing works
Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity
Bakker, W., Eringa, E. C., Sipkema, P., & van Hinsbergh, V. W. M. (2008) · Cell and Tissue Research · doi:10.1007/s00441-008-0685-6 · Cited by 343 · see citing works
The bone marrow at the crossroads of blood and immunity
Mercier, F., Ragu, C., & Scadden, D. T. (2011) · Nature reviews. Immunology · doi:10.1038/nri3132 · Cited by 338 · see citing works
Marizzoni, M., Cattaneo, A., Mirabelli, P., Festari, C., Lopizzo, N., Nicolosi, V., Mombelli, E., Mazzelli, M., Luongo, D., Naviglio, D., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200306 · Cited by 336 · see citing works
Endothelial cells in the pathogenesis of pulmonary arterial hypertension
Evans, C. E., Cober, N. D., Dai, Z., Stewart, D. J., & Zhao, Y. (2021) · European Respiratory Journal · doi:10.1183/13993003.03957-2020 · Cited by 328 · see citing works
Interrelation of immunity and tissue repair or regeneration
Eming, S. A., Hammerschmidt, M., Krieg, T., & Roers, A. (2009) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2009.04.009 · Cited by 321 · see citing works
Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum
Vieira‐de‐Abreu, A., Campbell, R. A., Weyrich, A. S., & Zimmerman, G. A. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0286-4 · Cited by 323 · see citing works
Liu, Y., Lian, K., Zhang, L., Wang, R., Yi, F., Gao, C., Xin, C., Zhu, D., Li, Y., Yan, W., et al. (2014) · Basic Research in Cardiology · doi:10.1007/s00395-014-0415-z · Cited by 322 · see citing works
The changing immune system in sepsis
Boomer, J. S., Green, J. M., & Hotchkiss, R. S. (2013) · Virulence · doi:10.4161/viru.26516 · Cited by 319 · see citing works
Galvani, S., Sanson, M., Blaho, V. A., Swendeman, S. L., Obinata, H., Conger, H., Dahlbäck, B., Kono, M., Proia, R. L., Smith, J. D., et al. (2015) · Science Signaling · doi:10.1126/scisignal.aaa2581 · Cited by 317 · see citing works
Platelets as Cellular Effectors of Inflammation in Vascular Diseases
Rondina, M. T., Weyrich, A. S., & Zimmerman, G. A. (2013) · Circulation Research · doi:10.1161/circresaha.113.300512 · Cited by 315 · see citing works
Nanoparticles' interactions with vasculature in diseases
Tee, J. K., Yip, L. X., Tan, E. S., Santitewagun, S., Prasath, A., Ke, P. C., Ho, H. K., & Leong, D. T. (2019) · Chemical Society Reviews · doi:10.1039/c9cs00309f · Cited by 315 · see citing works
Role of reactive oxygen and nitrogen species in the vascular responses to inflammation
Kvietys, P. R., & Granger, D. N. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.11.002 · Cited by 313 · see citing works
Speer, T., Rohrer, L., Blyszczuk, P., Shroff, R., Kuschnerus, K., Kränkel, N., Kania, G., Zewinger, S., Akhmedov, A., Shi, Y., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.009 · Cited by 310 · see citing works
Understanding and exploiting nanoparticles' intimacy with the blood vessel and blood
Setyawati, M. I., Tay, C. Y., Docter, D., Stauber, R. H., & Leong, D. T. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00499c · Cited by 308 · see citing works
Inflammation and the Blood Microvascular SystemPreprint
Pober, J. S., & Sessa, W. C. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016345 · Cited by 304 · see citing works
Self-citationVascular Endothelial Cells and Innate Immunity
Shao, Y., Saredy, J., Yang, W. Y., Sun, Y., Lu, Y., Saaoud, F., Drummer, C., Johnson, C., Xu, K., Jiang, X., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314330 · Cited by 302 · see citing works
Emerging roles of innate and adaptive immunity in Alzheimer’s disease
Chen, X., & Holtzman, D. M. (2022) · Immunity · doi:10.1016/j.immuni.2022.10.016 · Cited by 297 · see citing works
Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation
Wettschureck, N., Strilić, B., & Offermanns, S. (2019) · Physiological Reviews · doi:10.1152/physrev.00037.2018 · Cited by 282 · see citing works
C-reactive protein and inflammation: conformational changes affect function
Wu, Y., Potempa, L. A., Kebir, D. E., & Filep, J. G. (2015) · Biological Chemistry · doi:10.1515/hsz-2015-0149 · Cited by 286 · see citing works
Mechanisms Regulating Endothelial Permeability
Baweja, S., Tauseef, M., Yazbeck, P., & Mehta, D. (2014) · Pulmonary Circulation · doi:10.1086/677356 · Cited by 282 · see citing works
Thrombospondin-1: Multiple Paths to Inflammation
Lopez-Dee, Z. P., Pidcock, K. A., & Gutierrez, L. S. (2011) · Mediators of Inflammation · doi:10.1155/2011/296069 · Cited by 283 · see citing works
Setyawati, M. I., Tay, C. Y., Bay, B., & Leong, D. T. (2017) · ACS Nano · doi:10.1021/acsnano.7b01744 · Cited by 283 · see citing works
Engineering the multiscale complexity of vascular networks
O’Connor, C., Brady, E., Zheng, Y., Moore, E., & Stevens, K. R. (2022) · Nature Reviews Materials · doi:10.1038/s41578-022-00447-8 · Cited by 271 · see citing works
Mechanisms of Endothelial Dysfunction, Injury, and Death
Pober, J. S., Wang, M., & Bradley, J. R. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092155 · Cited by 272 · see citing works
Self-citationPivotal Advance: Th‐1 cytokines inhibit, and Th‐2 cytokines promote fibrocyte differentiation
Shao, D., Suresh, R., Vakil, V., Gomer, R., & Pilling, D. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107782 · Cited by 288 · see citing works
Sturtzel, C. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-57613-8_4 · Cited by 268 · see citing works
Micro- and nanoplastics: A new cardiovascular risk factor?
Zhu, X., Wang, C., Duan, X., Liang, B., Genbo Xu, E., & Huang, Z. (2023) · Environment International · doi:10.1016/j.envint.2022.107662 · Cited by 273 · see citing works
Cytokines and Chemokines in Cerebral Malaria Pathogenesis
Dunst, J., Kamena, F., & Matuschewski, K. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00324 · Cited by 264 · see citing works
Schildberger, A., Roßmanith, E., Eichhorn, T., Straßl, K., & Weber, V. (2013) · Mediators of Inflammation · doi:10.1155/2013/697972 · Cited by 263 · see citing works
Thrombosis in Coronavirus disease 2019 (COVID-19) through the prism of Virchow’s triad
Ahmed, S., Zimba, O., & Gasparyan, A. Y. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-05275-1 · Cited by 251 · see citing works
Inflammasomes in Tissue Damages and Immune Disorders After Trauma
Bortolotti, P., Faure, E., & Kipnis, É. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01900 · Cited by 259 · see citing works
Safi, S. Z., Qvist, R., Kumar, S., Batumalaie, K., & Ismail, I. S. (2014) · BioMed Research International · doi:10.1155/2014/801269 · Cited by 257 · see citing works
Innate Immune Responses to Danger Signals in Systemic Inflammatory Response Syndrome and Sepsis
Castellheim, A. G., Brekke, O., Espevik, T., Harboe, M., & Mollnes, T. E. (2009) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2009.02255.x · Cited by 259 · see citing works
Saleh, H. A., Yousef, M., & Abdelnaser, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.606069 · Cited by 204 · see citing works
von Willebrand factor and inflammation
Kawecki, C., Lenting, P. J., & Denis, C. V. (2017) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13696 · Cited by 251 · see citing works
Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation
Buckley, C. D., Barone, F., Nayar, S., Bénézech, C., & Caamaño, J. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120252 · Cited by 249 · see citing works
Medina-Leyte, D. J., Domínguez‐Pérez, M., Mercado, I., Villarreal-Molina, M. T., & Jacobo‐Albavera, L. (2020) · Applied Sciences · doi:10.3390/app10030938 · Cited by 249 · see citing works
TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering
Ma, J., Sánchez‐Duffhues, G., Goumans, M., & ten Dijke, P. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00260 · Cited by 247 · see citing works
Extracellular vesicles as emerging intercellular communicasomes
Yoon, Y., Kim, O. Y., & Gho, Y. (2014) · BMB Reports · doi:10.5483/bmbrep.2014.47.10.164 · Cited by 227 · see citing works
Combinations of Immunotherapy and Radiation in Cancer Therapy
Vatner, R. E., Cooper, B. T., Vanpouille‐Box, C., Demaria, S., & Formenti, S. C. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00325 · Cited by 241 · see citing works
Vascular endothelial cell Toll-like receptor pathways in sepsis
Khakpour, S., Wilhelmsen, K., & Hellman, J. (2015) · Innate Immunity · doi:10.1177/1753425915606525 · Cited by 232 · see citing works
Diabetic retinopathy and inflammation: Novel therapeutic targets
Das, A., Rangasamy, S., & McGuire, P. G. (2012) · Middle East African Journal of Ophthalmology · doi:10.4103/0974-9233.92116 · Cited by 231 · see citing works
Plasmin as a proinflammatory cell activator
Syrovets, T., Lunov, O., & Simmet, T. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212056 · Cited by 215 · see citing works
Gehrke, N., & Schattenberg, J. M. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.02.020 · Cited by 211 · see citing works
Carman, C. V., & Martinelli, R. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00603 · Cited by 208 · see citing works
The Role of Tumor Inflammatory Microenvironment in Lung Cancer
Tan, Z., Xue, H., Sun, Y., Zhang, C., Song, Y., & Qi, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.688625 · Cited by 204 · see citing works
Wnt5a Induces Endothelial Inflammation via β-Catenin–Independent Signaling
Kim, J., Kim, D. W., Kim, D. W., Ha, Y., Ihm, M. H., Kim, H., Song, K., & Lee, I. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000181 · Cited by 202 · see citing works
Understanding tumour endothelial cell heterogeneity and function from single-cell omics
Zeng, Q., Mousa, M., Nadukkandy, A. S., Franssens, L., Alnaqbi, H., Alshamsi, F., Safar, H. A., & Carmeliet, P. (2023) · Nature Reviews. Cancer · doi:10.1038/s41568-023-00591-5 · Cited by 196 · see citing works
Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19
Alon, R., Sportiello, M., Kozlovski, S., Kumar, A., Reilly, E. C., Zarbock, A., Garbi, N., & Topham, D. J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00470-2 · Cited by 197 · see citing works
Vascular Targeting of Nanocarriers: Perplexing Aspects of the Seemingly Straightforward Paradigm
Howard, M. D., Zern, B. J., Anselmo, A. C., Shuvaev, V. V., Mitragotri, S., & Muzykantov, V. R. (2014) · ACS Nano · doi:10.1021/nn500136z · Cited by 197 · see citing works
Hu, R., Wang, M., Ni, S.-H., Wang, M., Liu, L., You, H., Wu, X., Wang, Y., Lu, L., & Wei, L. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172797 · Cited by 196 · see citing works
- Authors
- Pober, J. S., & Sessa, W. C.
- Affiliations
- Yale University (US)
- Corresponding author
- Pober, Jordan S.
- Venue
- Nature Reviews Immunology
- Published
- 2007-10
- Volume
- 7
- Issue
- 10
- Pages
- 803-815
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2171783221
- Cited by
- 2,022
- References
- 99
- Citations by year
- 2026: 147 · 2025: 138 · 2024: 163 · 2023: 138 · 2022: 185 · 2021: 194 · 2020: 151 · 2019: 100 · 2018: 104 · 2017: 120 · 2016: 75 · 2015: 100 · 2014: 78 · 2013: 74 · 2012: 77
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- endothelial cells, inflammation, acute and chronic inflammation, leukocyte-endothelium interaction, vascular inflammation, anti-inflammatory therapy, inflammatory mediators
- MeSH terms
- Animals, Anti-Inflammatory Agents, Communicable Diseases, Histamine, Humans, Inflammation, Wounds and Injuries, Signal Transduction, Cytokines, Endothelial Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review