The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Gender differences in sepsis: Cardiovascular and immunological aspects
Open accessAbstract
During sepsis, a complex network of cytokine, immune, and endothelial cell interactions occur and disturbances in the microcirculation cause organ dysfunction or even failure leading to high mortality in those patients. In this respect, numerous experimental and clinical studies indicate sex-specific differences in infectious diseases and sepsis. Female gender has been demonstrated to be protective under such conditions, whereas male gender may be deleterious due to a diminished cell-mediated immune response and cardiovascular functions. Male sex hormones, i.e., androgens, have been shown to be suppressive on cell-mediated immune responses. In contrast, female sex hormones exhibit protective effects which may contribute to the natural advantages of females under septic conditions. Thus, the hormonal status has to be considered when treating septic patients. Therefore, potential therapies could be derived from this knowledge. In this respect, administration of female sex hormones (estrogens and their precursors) may exert beneficial effects. Alternatively, blockade of male sex hormone receptors could result in maintained immune responses under adverse circulatory conditions. Finally, administration of agents that influence enzymes synthesizing female sex hormones which attenuate the levels of pro-inflammatory agents might exert salutary effects in septic patients. Prospective patient studies are required for transferring those important experimental findings into the clinical arena.
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Cites
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
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Cited by
Suppressive effects of androgens on the immune system
Trigunaite, A., Dimo, J., & Jørgensen, T. N. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.02.004 · Cited by 551
Köhler-Forsberg, O., Buttenschøn, H. N., Tansey, K. E., Maier, W., Hauser, J., Dernovsek, M. Z., Henigsberg, N., Souery, D., Farmer, A., Rietschel, M., et al. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.02.020 · Cited by 283
Influence of Androgens on Immunity to Self and Foreign: Effects on Immunity and Cancer
Ben-Batalla, I., Vargas-Delgado, M. E., von Amsberg, G., Janning, M., & Loges, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01184 · Cited by 149
“Remarkably, in preclinical models, administration of the anti-androgen flutamide after the induction of sepsis, was able not only to reestablish the low cytokine released levels by splenic macrophages and splenocytes, but also significantly decreased the mortality of post-hemorrhaged mice (68).”
BackgroundMorales, M. G., Olguín, H., Di Capua, G., Brandan, E., Simon, F., & Cabello-Verrugio, C. (2015) · Clinical Science · doi:10.1042/cs20140840 · Cited by 62
Köhler, O., Sylvia, L. G., Bowden, C. L., Calabrese, J. R., Thase, M., Shelton, R. C., McInnis, M., Tohen, M., Kocsis, J. H., Ketter, T. A., et al. (2017) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867416644508 · Cited by 33
Lee, S., Oh, S. S., Jang, S.-I., & Park, E.-C. (2019) · Scientific Reports · doi:10.1038/s41598-018-36402-3 · Cited by 29
Köhler-Forsberg, O., Sylvia, L., Deckersbach, T., Ostacher, M. J., McInnis, M., Iosifescu, D., Bowden, C., McElroy, S., Calabrese, J., Thase, M., et al. (2018) · Acta Neuropsychiatrica · doi:10.1017/neu.2017.34 · Cited by 15
Metadata
- Authors
- Angele, M. K., Pratschke, S., Hubbard, W. J., & Chaudry, I. H.
- Venue
- Virulence
- Publisher
- Informa UK Limited
- Published
- 2013-11-05
- Volume
- 5
- Issue
- 1
- Pages
- 12-19
- ISSN
- 2150-5594 (ISSN-L)
- 2150-5608
- OpenAlex
- W2081415485
- Cited by
- 344
- References
- 3
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
