Viral Infections and associated factors that promote acute exacerbations of asthma
Open accessAbstract
Despite asthma being the most common chronic childhood ailment, there is still much to learn about the disease. Early childhood infections with well-known or emerging viruses can lay the pathophysiologic framework for asthma development and exacerbation later in life, which may be due partly to alteration of the airway microbiome. Once asthma is established, acute exacerbations are usually associated with infections with respiratory viruses, such as rhinoviruses (RVs). Once again, there are bidirectional interactions between viruses and airway bacteria that appear to influence the severity of illness and the likelihood of exacerbation. Studies employing recent advances in viral and bacterial identification analytic techniques will clarify these new concepts and may provide the basis for new treatments or prevention or respiratory infection-associated exacerbation. This paper is a review of the associations among respiratory viruses, bacteria, inflammatory mechanisms, and asthma exacerbation.
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Impaired innate anti-viral immunity with diminished interferon induction to rhinovirus has been reported in both children and adults with severe asthma.
“Impaired innate anti-viral immunity with diminished interferon induction to rhinovirus has been reported in both children and adults with severe asthma (77–79).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [78]
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Associated Factors for Asthma Severity in Korean Children: A Korean Childhood Asthma Study
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Association of Genetic Variants of NLRP4 with Exacerbation of Asthma: The Effect of Smoking
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- Authors
- Kim, C.-K., Callaway, Z., & Gern, J. E.
- Affiliations
- Inje University Sanggye Paik Hospital (KR)
- University of Ulsan (KR)
- University of Wisconsin–Madison (US)
- Corresponding author
- Gern, James E.
- Venue
- Allergy, Asthma & Immunology Research
- Publisher
- XMLink
- Published
- 2018
- Volume
- 10
- Issue
- 1
- Pages
- 12
- ISSN
- 2092-7355 (ISSN-L)
- 2092-7363
- PMC
- PMC5705478
- OpenAlex
- W2767101280
- Cited by
- 59
- References
- 70
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 6 · 2020: 11 · 2019: 13 · 2018: 10
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Allergy Asthma and Immunology Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Inje University
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- asthma exacerbations, respiratory viruses, rhinovirus, airway microbiome, viral-bacterial interactions, airway bacteria, pediatric infection, asthma pathogenesis, airway inflammation, emerging viruses
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