Effects of a novel dental gel on plaque and gingivitis: a comparative study
Open accessAbstract
OBJECTIVES: The goal of this prospective, randomized, controlled, double-blinded study was to evaluate the effects of a novel dental gel on plaque and gingival health. The dental gel was designed to (1) break up and prevent re-accumulation of microbial biofilm, and (2) inhibit metal mediated inflammation. MATERIALS AND METHODS: Twenty-five subjects with moderate gingival inflammation (Löe and Silness Gingival Index ≥2) and pocket depths <4 were randomly assigned to brush twice daily for 21 days with the test or the control dental gel. On Days 0, 7, 14 and 21, plaque levels (Quigley-Hein, Turesky Modification Plaque Index), gingival inflammation (Löe and Silness Gingival Index) and gingival bleeding (modified Sulcus Bleeding Index) were determined by one blinded, investigator using a pressure sensitive probe. RESULTS: After 3 weeks, all 3 clinical indices were significantly improved in both groups (P<0.05) and significantly lower in the test group (P<0.05). CONCLUSION: The novel dental gel formulation was provided effective plaque control and reduced gingival inflammation. CLINICAL RELEVANCE: A novel dentifrice formulation may be an effective tool for plaque removal and maintaining gingival health.
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Prior investigations of 2.6% EDTA dentifrice lacked fluoride in the formulation.
“These previous investigations of 2.6% EDTA containing dentifrice lacked the inclusion of fluoride in the formulation.”
From Better living through chemistry? A randomized, double-blind controlled study evaluating the efficacy of plaque control and gingival health impacts of a novel stannous fluoride-containing gel (2023) · cites this paper as [22]
The Introduction identifies the tested dentifrice as containing 2.6% activated edathamil, and the Clinical Protocol identifies it as Livionex Dental Gel. Our copy does not say whether that formulation contained fluoride, so it does not support the claim that fluoride was absent. (LLM, conf=0.78)
Experimental — accuracy not yet measuredThe comparative efficacy of a similar dentifrice formulation without stannous fluoride in plaque and gingival inflammatory reduction is consistent across studies.
“While only one of these reports evaluates a formulation that includes stannous fluoride, 26 the comparative efficacy of a similar dentifrice formulation without stannous fluoride in plaque and gingival inflammatory reduction is consistent across studies. 20-26”
From A randomized double-blind clinical trial evaluating comparative plaque and gingival health associated with commercially available stannous fluoride-containing dentifrices as compared to a sodium fluoride control dentifrice (2023) · cites this paper as [20]
The Results (page not provided) report greater reductions in plaque and gingival inflammation with the test gel than with the control. The Introduction identifies activated edathamil in the test formulation, but the paper does not establish that comparative efficacy is consistent across studies or explicitly confirm the absence of stannous fluoride. (LLM, conf=0.84)
Experimental — accuracy not yet measuredPrevious studies have demonstrated enhanced plaque reduction and improved gingival health in patients with gingivitis using the D1 dentifrice formulated without fluoride.
“These studies have demonstrated enhanced plaque reduction and improved gingival health in patients with gingivitis. 20,31”
From A randomized double-blind clinical trial evaluating comparative plaque and gingival health associated with commercially available stannous fluoride-containing dentifrices as compared to a sodium fluoride control dentifrice (2023) · cites this paper as [20]
The Results report greater plaque reduction and improvement in gingival inflammation with the test gel than with the control gel in participants who had gingival inflammation. The Clinical Protocol identifies the test product as Livionex Dental Gel; our copy does not identify it as D1 or establish that it was formulated without fluoride. (LLM, conf=0.86)
Experimental — accuracy not yet measuredPrevious investigations lacked comparison between multiple commercially-available dentifrices, including a direct comparison with other stannous fluoride formulations.
“A critique of previous investigations included a lack of comparison between multiple commercially-available dentifrices, including a direct comparison with other stannous fluoride formulations. 20-26”
From A randomized double-blind clinical trial evaluating comparative plaque and gingival health associated with commercially available stannous fluoride-containing dentifrices as compared to a sodium fluoride control dentifrice (2023) · cites this paper as [20]
The Clinical Protocol describes this paper’s comparison of a novel dental gel with Colgate Total, and the Discussion calls for further study of those two dentifrices. Neither passage critiques previous investigations for failing to compare multiple commercial dentifrices or other stannous fluoride formulations (searched those terms and paraphrases). (LLM, conf=0.75)
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Cites
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Toothbrush efficacy for plaque removal
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Flagged first, then by citations
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Cited by
Sorted by citations
Kaur, M., Geurs, N. C., Cobb, C. M., Otomo‐Corgel, J., Takesh, T., Lee, J. H., Lam, T. M., Lin, K., Nguyen, A., Nguyen, B. L., et al. (2021) · Journal of Periodontology · doi:10.1002/jper.20-0721 · Cited by 11 · see citing works
Plaque Removal and Gingival Health after Use of a Novel Dental Gel: A Clinical Study
Nayudu, A., & Lam, T. (2016) · Dentistry · doi:10.4172/2161-1122.1000396 · Cited by 10 · see citing works
“These results are supported by data from previous imaging and clinical studies which indicate that the test gel very effectively reduces plaque levels in the oral cavity, as well as inflammation and bleeding [34].”
ResultTakesh, T., Goshtasbi, A., Lin, K., Yang, S. M., Wink, C., Geisinger, M. L., & Wilder‐Smith, P. (2023) · Journal of Periodontology · doi:10.1002/jper.22-0254 · Cited by 4 · see citing works
Geisinger, M. L., Geurs, N. C., Novy, B., Otomo‐Corgel, J., Cobb, C. M., Jacobsen, P. L., Takesh, T., & Wilder‐Smith, P. (2023) · Journal of Periodontology · doi:10.1002/jper.22-0675 · Cited by 3 · see citing works
- Authors
- Smith P, W.
- Venue
- Dentistry
- Publisher
- OMICS Publishing Group
- Published
- 2014
- Volume
- 04
- Issue
- 06
- Pages
- 239-239
- ISSN
- 2161-1122 (ISSN-L)
- PMC
- PMC4454341
- OpenAlex
- W2186587329
- Cited by
- 13
- References
- 3
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 1
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Dentistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion, cc-by)
- PubMed Central (acceptedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (R21DA031571)
- National Institute of Biomedical Imaging and Bioengineering (R03EB014852, P41EB015890)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
- Keywords
- dental gel, toothpaste, dental plaque, gingivitis, gingival bleeding, biofilm, plaque control, gingival health
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