Retinal examination for the diagnosis of Alzheimer's disease
Abstract
We examined 20 patients with mild cognitive impairment (MCI). In the patients in whom we found hyper or hypo fluorescent lesions on fundus auto fluorescence (FAF), optical scanning tomography (OCT) was performed through these regions to reveal depositions in the retina. Drusen like spots- dots were noticed in different parts of the retina. 10 randomly chosen patients and 10 age-matched healthy controls were given curcumin to check for the changes in FAF and OCT.
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Systemic administration of curcumin to AD mice resulted in specific in vivo labeling of retinal Aβ plaques.
“In relation to this last point, it has been demonstrated that the systemic administration of curcumin to AD mice resulted in specific in vivo labeling of retinal Aβ plaques.”
From The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma. (2017) · cites this paper as Kayabasi et al., 2014
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The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.
Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466 · see citing works
- Authors
- Kayabasi, U.
- Corresponding author
- Kayabasi, Umur
- Venue
- International Journal of Ophthalmic & Pathology
- Publisher
- OMICS Publishing Group
- Published
- 2014
- Volume
- 03
- Issue
- 04
- ISSN
- 2324-8599 (ISSN-L)
- OpenAlex
- W2123965734
- Cited by
- 34
- References
- 17
- Citations by year
- 2025: 2 · 2024: 1 · 2021: 3 · 2020: 8 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 2
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Ophthalmic Pathology (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- Alzheimer's disease, mild cognitive impairment, retinal examination, fundus autofluorescence, optical coherence tomography, curcumin, retinal biomarkers
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