Effect of Heated Humidification on CPAP Therapy Adherence in Subjects With Obstructive Sleep Apnea With Nasopharyngeal Symptoms
Open accessAbstract
BACKGROUND: The addition of heated humidification to CPAP has been shown to improve nasal adverse effects in subjects with obstructive sleep apnea (OSA). However, current data regarding improvement in CPAP adherence is conflicting. Furthermore, there are no data from a tropical climate area with a high humidity level. METHODS: In this prospective randomized crossover study conducted in Thailand, subjects with moderate to severe OSA with nasopharyngeal symptoms post-split-night study were enrolled in the study. Subjects were randomly assigned to receive CPAP with or without heated humidification for 4 weeks and then crossed over. Information on CPAP adherence, quality of life assessed by the Functional Outcomes of Sleep Questionnaire, nasopharyngeal symptoms assessed by a modified XERO questionnaire, and bedroom ambient humidity and temperature data were obtained. RESULTS: Data were collected on 20 subjects with OSA during the period of January to December 2014. Although the addition of heated humidification appeared to improve average hours of use for all days when compared with conventional CPAP, the difference was not statistically significant (CPAP with heated humidification = 4.6 ± 1.7 h/night; conventional CPAP = 4.0 ± 1.7 h/night, P = .1). However, the addition of heated humidification improved CPAP adherence on the days of use (5.5 ± 1.5 h/night) compared with conventional CPAP (5.2 ± 1.4 h/night), P = .033. Quality of life was also improved according to the Functional Outcomes of Sleep Questionnaire score (median 17.6 [interquartile range 3.5]) in the heated humidification group compared with conventional CPAP group (median 17.6 [interquartile range 4.5]), P = .046. Significant reduction in the dry throat/sore throat symptom was noted only when CPAP with heated humidification was used. CONCLUSIONS: Even in a tropical climate area, CPAP adherence and quality of life appeared to improve when heated humidification was employed in subjects with moderate to severe OSA with nasopharyngeal symptoms post-split-night polysomnography. The improvement may be related to a reduction in the dry throat/sore throat symptom.
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The studies assessed only participants with newly diagnosed OSA with no prior history of treatment and only one study specifically recruited individuals with nasal symptoms.
“The studies assessed only participants with newly diagnosed OSA with no prior history of treatment and only one study 266 specifically recruited individuals with nasal symptoms.”
In one study, while overall nasopharyngeal scores were not significantly different, complaints of dry or sore throat were significantly less with humidified than non-humidified PAP.
“In one study, while overall nasopharyngeal scores were not significantly different, complaints of dry or sore throat were significantly less with humidified than non-humidified PAP.266”
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- Authors
- Soudorn, C., Muntham, D., Reutrakul, S., & Chirakalwasan, N.
- Affiliations
- Thai Red Cross Society (TH)
- Mahidol University (TH)
- Venue
- Respiratory Care
- Publisher
- SAGE Publications
- Published
- 2016-05-24
- Volume
- 61
- Issue
- 9
- Pages
- 1151-1159
- ISSN
- 0020-1324 (ISSN-L)
- OpenAlex
- W2396398978
- Semantic Scholar
- f5384416b9b0c3afac90d3df364f1e437802cd2f
- Cited by
- 26
- References
- 22
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 3 · 2016: 1
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Respiratory Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sanofi
- Chulalongkorn University
- Fisher and Paykel Healthcare
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Keywords
- heated humidification, CPAP therapy, obstructive sleep apnea, CPAP adherence, dry throat, sore throat, quality of life, tropical climate, high humidity
- MeSH terms
- Adult, Female, Hot Temperature, Humans, Humidity, Male, Middle Aged, Patient Compliance, Pharyngitis, Prospective Studies, Quality of Life, Temperature, Thailand, Xerostomia, Nasal Obstruction, Cross-Over Studies, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure
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