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Cited by 81Sinusitis and nasal conditionsNasal Surgery and Airway StudiesOlfactory and Sensory Function Studies

Nasal obstruction and smell impairment in nasal polyp disease: correlation between objective and subjective parameters

Hox, V., Bobic, S., Callebaux, I., Jorissen, M., Hellings, P.W.·2010·Rhinology journal
DOI 10.4193/rhino10.049
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Abstract

Background: Chronic rhinosinusitis with nasal polyposis (NP) represents an invalidating disorder that causes mainly nasal blockage and loss of smell. The aim of this study is to investigate correlations between individual subjective and objective parameters of stable NP disease. Methods: 65 NP patients scored their sinonasal symptoms on a visual analogue scale (VAS) and questionnaires (SNOT-22 and SF-36). Peak nasal inspiratory flow (PNIF) measurement, Sniffinatm Sticks (SS) smell test, blood analysis for eosinophilia, total IgE and culture for Staphylococcus aureus (SA) were performed. Results: VAS scores for nasal blockage correlated with the SNOT-22 and SF-36 scores, which was not observed for VAS of other symptoms. VAS scores for nasal blockage correlated well with PNIF values as well as VAS scores for smell dysfunction and SS results (both p<0.001). NP size correlated with VAS scores for nasal blockage (p<0.01) but not with VAS for other symptoms. NP size showed an inverse correlation with PNIF and SS scores (both p<0.05). Blood eosinophilia correlated with subjective smell reduction (p<0.05). The presence of SA or total IgE levels were not associated with symptoms of NP disease. Conclusion: PNIF and SS are good tools to evaluate symptoms of nasal obstruction and smell reduction in NP disease. Nasal blockage is the only symptom that correlates well with NP size and SNOT-22 scores, whereas smell reduction correlates with blood eosinophilia.

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  • A study in 65 patients with nasal polyposis revealed a significant but weak inverse correlation (r=-0.29) between PNIF and polyp size based on endoscopic findings.

    “A study conducted in 65 patients with NP revealed a significant but weak inverse correlation (r=-0.29) between PNIF and polyp size based on endoscopic findings [82].”

    From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [82]

  • A moderate correlation was detected between the endoscopic size of polyps and evaluation of NO by VAS in patients with nasal polyposis.

    “A moderate correlation was detected between the endoscopic size of the polyps and the evaluation of NO by VAS [82] in patients with NP.”

    From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [82]

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Authors
Hox, V., Bobic, S., Callebaux, I., Jorissen, M., & Hellings, P. W.
Affiliations
KU Leuven (BE)
ORCID
Venue
Rhinology journal
Publisher
Stichting Nase
Published
2010-12-01
Volume
48
Issue
4
Pages
426-432
ISSN
0300-0729 (ISSN-L)
DOI
10.4193/rhino10.049
OpenAlex
W107044012
Cited by
81
References
1
Citations by year
2026: 2 · 2025: 6 · 2024: 8 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 5 · 2012: 3
FWCI
3.21
Type
journal article
Language
en
Open access
closed
Locations
  • Rhinology Journal (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
Topics
  • Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
  • Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords
nasal polyps, chronic rhinosinusitis, nasal obstruction, smell impairment, peak nasal inspiratory flow, SNOT-22, SF-36, eosinophilia, total IgE, Staphylococcus aureus
MeSH terms
Administration, Intranasal, Adrenal Cortex Hormones, Adult, Aged, Anti-Inflammatory Agents, Chronic Disease, Cross-Sectional Studies, Eosinophilia, Female, Humans, Male, Middle Aged, Nasal Polyps, Pain Measurement, Surveys and Questionnaires, Rhinitis, Severity of Illness Index, Sinusitis, Smell, Staphylococcus aureus, Tomography, X-Ray Computed, Nasal Obstruction, Treatment Outcome, Patient Satisfaction

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