Expression and significance of plasma 3-NT and ox-LDL in patients with Alzheimer's disease
Open accessAbstract
To examine the expression and clinical significance of plasma 3-nitrotyrosine (3-NT) and oxidized low-density lipoprotein (ox-LDL) levels in patients with Alzheimer's disease (AD), we examined 48 AD patients and 37 healthy control subjects. The Mini-Mental State Examination, Activities of Daily Living Scale, and Hachinski Ischemic Scale were examined in all subjects. AD patients were classified using the Global Deterioration Scale. The concentrations of plasma 3-NT and ox-LDL were detected using an enzyme-linked immunosorbent assay. We found that the plasma 3-NT concentration in the AD group (119.46 ± 21.82 nM) was significantly higher than that in the control group (55.09 ± 9.63 nM) (P < 0.05). Spearman analysis showed that plasma 3-NT level was negatively associated with the Mini-Mental State Examination results of AD patients. Plasma ox-LDL level in the AD group (112.25 ± 17.81 mg/L) was significantly higher than that in the control group (47.46 ± 10.04 mg/L) (P < 0.05). Spearman analysis showed that plasma ox-LDL level was positively correlated with AD severity in AD patients. However, plasma 3-NT level in the AD group was not associated with plasma ox-LDL level. Therefore, plasma 3-NT and ox-LDL levels in AD patients were significantly increased, which may be related to the degree of AD severity in AD patients.
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Elevated 3-NT levels in age-related diseases such as AD and PD indicate the impact of 3-NT accumulation in human aging.
“elevated 3-NT levels in age-related diseases, such as AD and PD, indicate the impact of 3-NT accumulation in human aging”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [192]
The Plasma 3-NT and ox-LDL level section and Table 3 report significantly higher plasma 3-NT in AD patients than in healthy controls. The paper does not report elevated 3-NT in PD or establish that 3-NT accumulation affects human aging; its findings concern AD and AD severity. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIn AD patients, plasma 3-NT concentrations are higher compared to healthy subjects (ELISA).
“Higher plasma 3-NT concentrations in AD patients”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [192]
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- Authors
- Zhao, Z., Zhou, H., Peng, Y., Qiu, C. H., Sun, Q. Y., Wang, F., & Xie, H. N.
- Affiliations
- Nanjing Medical University (CN)
- Venue
- Genetics and Molecular Research
- Publisher
- Genetics and Molecular Research
- Published
- 2014
- Volume
- 13
- Issue
- 4
- Pages
- 8428-8435
- ISSN
- 1676-5680 (ISSN-L)
- OpenAlex
- W2330917979
- Cited by
- 19
- References
- 21
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2017: 3 · 2016: 1 · 2015: 1
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genetics and Molecular Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- Alzheimer's disease, nitrotyrosine, oxidized LDL, oxidative stress, plasma biomarkers, disease severity, cognitive impairment, lipid peroxidation
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Lipoproteins, LDL, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Tyrosine, Gene Expression, Case-Control Studies
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