Cited by 19Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAntioxidant Activity and Oxidative Stress

Expression and significance of plasma 3-NT and ox-LDL in patients with Alzheimer's disease

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Zhao, Z., Zhou, H., Peng, Y., Qiu, C.H., Sun, Q.Y., Wang, F., Xie, H.N.·2014·Genetics and Molecular Research

Abstract

To examine the expression and clinical significance of plasma 3-nitrotyrosine (3-NT) and oxidized low-density lipoprotein (ox-LDL) levels in patients with Alzheimer's disease (AD), we examined 48 AD patients and 37 healthy control subjects. The Mini-Mental State Examination, Activities of Daily Living Scale, and Hachinski Ischemic Scale were examined in all subjects. AD patients were classified using the Global Deterioration Scale. The concentrations of plasma 3-NT and ox-LDL were detected using an enzyme-linked immunosorbent assay. We found that the plasma 3-NT concentration in the AD group (119.46 ± 21.82 nM) was significantly higher than that in the control group (55.09 ± 9.63 nM) (P < 0.05). Spearman analysis showed that plasma 3-NT level was negatively associated with the Mini-Mental State Examination results of AD patients. Plasma ox-LDL level in the AD group (112.25 ± 17.81 mg/L) was significantly higher than that in the control group (47.46 ± 10.04 mg/L) (P < 0.05). Spearman analysis showed that plasma ox-LDL level was positively correlated with AD severity in AD patients. However, plasma 3-NT level in the AD group was not associated with plasma ox-LDL level. Therefore, plasma 3-NT and ox-LDL levels in AD patients were significantly increased, which may be related to the degree of AD severity in AD patients.

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Crossref · 10.4238/2014.october.20.19

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  • Elevated 3-NT levels in age-related diseases such as AD and PD indicate the impact of 3-NT accumulation in human aging.

    “elevated 3-NT levels in age-related diseases, such as AD and PD, indicate the impact of 3-NT accumulation in human aging”

    From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [192]

    The Plasma 3-NT and ox-LDL level section and Table 3 report significantly higher plasma 3-NT in AD patients than in healthy controls. The paper does not report elevated 3-NT in PD or establish that 3-NT accumulation affects human aging; its findings concern AD and AD severity. (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • In AD patients, plasma 3-NT concentrations are higher compared to healthy subjects (ELISA).

    “Higher plasma 3-NT concentrations in AD patients”

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Authors
Zhao, Z., Zhou, H., Peng, Y., Qiu, C. H., Sun, Q. Y., Wang, F., & Xie, H. N.
Affiliations
Nanjing Medical University (CN)
Venue
Genetics and Molecular Research
Published
2014
Volume
13
Issue
4
Pages
8428-8435
ISSN
1676-5680 (ISSN-L)
OpenAlex
W2330917979
Cited by
19
References
21
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2017: 3 · 2016: 1 · 2015: 1
FWCI
1.27
Type
journal article
Language
en
Open access
Locations
  • Genetics and Molecular Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
Alzheimer's disease, nitrotyrosine, oxidized LDL, oxidative stress, plasma biomarkers, disease severity, cognitive impairment, lipid peroxidation
MeSH terms
Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Lipoproteins, LDL, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Tyrosine, Gene Expression, Case-Control Studies

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