Adrenomedullin and diabetes
Open accessAbstract
Adrenomedullin (ADM) is a peptide hormone widely expressed in different tissues, especially in the vasculature. Apart from its vasodilatatory and hypotensive effect, it plays multiple roles in the regulation of hormonal secretion, glucose metabolism and inflammatory response. ADM regulates insulin balance and may participate in the development of diabetes. The plasma level of ADM is increased in people with diabetes, while in healthy individuals the plasma ADM concentration remains low. Plasma ADM levels are further increased in patients with diabetic complications. In type 1 diabetes, plasma ADM level is correlated with renal failure and retinopathy, while in type 2 diabetes its level is linked with a wider range of complications. The elevation of ADM level in diabetes may be due to hyperinsulinemia, oxidative stress and endothelial injury. At the same time, a rise in plasma ADM level can trigger the onset of diabetes. Strategies to reduce ADM level should be explored so as to reduce diabetic complications.
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ADM secretion is induced by inflammation, hypoxia and insulin resistance, and CVD and type 2 diabetes are linked to increased ADM levels.
“Secretion of ADM is induced in response to inflammation, hypoxia and insulin resistance such that CVD and type 2 diabetes (T2D) are linked to increased levels of ADM (4, 5).”
From Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS (2018) · cites this paper as [4]
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- Authors
- Wong, H. K.
- Affiliations
- University of Hong Kong (HK)
- Corresponding author
- Wong, Hoi Kin
- Venue
- World Journal of Diabetes
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 5
- Issue
- 3
- Pages
- 364
- ISSN
- 1948-9358 (ISSN-L)
- PMC
- PMC4058740
- OpenAlex
- W2064397364
- Cited by
- 51
- References
- 72
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 7 · 2015: 2
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Diabetes (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- adrenomedullin, diabetes mellitus, type 1 diabetes, type 2 diabetes, diabetes complications, insulin regulation, glucose metabolism, hyperinsulinemia, oxidative stress, endothelial injury, renal failure, diabetic retinopathy, vasodilation, plasma hormone levels
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