Cited by 52Neuropeptides and Animal PhysiologyAdipokines, Inflammation, and Metabolic DiseasesPancreatic function and diabetes

Adrenomedullin and diabetes

Open access
Wong, Hoi Kin·2014·World Journal of Diabetes

Abstract

Adrenomedullin (ADM) is a peptide hormone widely expressed in different tissues, especially in the vasculature. Apart from its vasodilatatory and hypotensive effect, it plays multiple roles in the regulation of hormonal secretion, glucose metabolism and inflammatory response. ADM regulates insulin balance and may participate in the development of diabetes. The plasma level of ADM is increased in people with diabetes, while in healthy individuals the plasma ADM concentration remains low. Plasma ADM levels are further increased in patients with diabetic complications. In type 1 diabetes, plasma ADM level is correlated with renal failure and retinopathy, while in type 2 diabetes its level is linked with a wider range of complications. The elevation of ADM level in diabetes may be due to hyperinsulinemia, oxidative stress and endothelial injury. At the same time, a rise in plasma ADM level can trigger the onset of diabetes. Strategies to reduce ADM level should be explored so as to reduce diabetic complications.

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Registry

Crossref · 10.4239/wjd.v5.i3.364

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  • ADM secretion is induced by inflammation, hypoxia and insulin resistance, and CVD and type 2 diabetes are linked to increased ADM levels.

    “Secretion of ADM is induced in response to inflammation, hypoxia and insulin resistance such that CVD and type 2 diabetes (T2D) are linked to increased levels of ADM (4, 5).”

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Authors
Wong, H. K.
Affiliations
University of Hong Kong (HK)
Corresponding author
Wong, Hoi Kin
Venue
World Journal of Diabetes
Published
2014
Volume
5
Issue
3
Pages
364
ISSN
1948-9358 (ISSN-L)
OpenAlex
W2064397364
Cited by
51
References
72
Citations by year
2026: 1 · 2025: 6 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 7 · 2015: 2
FWCI
1.68
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Diabetes (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords
adrenomedullin, diabetes mellitus, type 1 diabetes, type 2 diabetes, diabetes complications, insulin regulation, glucose metabolism, hyperinsulinemia, oxidative stress, endothelial injury, renal failure, diabetic retinopathy, vasodilation, plasma hormone levels

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