Cardiac stress testing and coronary artery disease in liver transplantation candidates: meta-analysis
Open accessAbstract
AIM: To evaluate the diagnostic value of dobutamine stress echocardiography (DSE) and myocardial perfusion scintigraphy (MPS) in predicting coronary artery disease (CAD) in cirrhotic patients listed for liver transplantation (LT), using invasive coronary angiography (ICA) as gold-standard. METHODS: Retrieval of studies was based on Medical Subject Headings and Health Sciences Descriptors, which were combined using Boolean operators. Searches were run on the electronic databases Scopus, Web of Science, EMBASE, MEDLINE (PubMed), BIREME (Biblioteca Regional de Medicina), LILACS (Latin American and Caribbean Health Sciences Literature), Cochrane Library for Systematic Reviews and Opengray.eu. There was no language or date of publication restrictions. The reference lists of the studies retrieved were searched manually. RESULTS: The search strategy retrieved 322 references for DSE and 90 for MPS. In the final analysis, 10 references for DSE and 10 for MPS were included. Pooled sensitivity was 28% and 61% for DSE and MPS and specificity was 82% and 74%, for diagnosis of CAD using ICA as gold-standard, respectively. CONCLUSION: DSE and MPS do not have adequate sensitivity for determination of whether CAD is present, despite having significant specificity.
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A meta-analysis found low sensitivities of 28% for stress echocardiography and 61% for myocardial perfusion scintigraphy for detection of coronary artery disease in liver transplant candidates.
“However, a meta-analysis found low sensitivities of 28% for stress echocardiography and 61% for myocardial perfusion scintigraphy for detection of coronary artery disease in liver transplant candidates. 492”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [492]
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- Authors
- Soldera, J., Camazzola, F., Rodríguez, S., & Brandão, A.
- Affiliations
- Universidade de Caxias do Sul (BR)
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- Venue
- World Journal of Hepatology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2018-11-27
- Volume
- 10
- Issue
- 11
- Pages
- 877-886
- ISSN
- 1948-5182 (ISSN-L)
- PMC
- PMC6280161
- OpenAlex
- W2902208579
- Cited by
- 33
- References
- 51
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 3 · 2014: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Hepatology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- dobutamine stress echocardiography, myocardial perfusion scintigraphy, coronary artery disease, liver transplant candidates, liver cirrhosis, diagnostic accuracy, sensitivity and specificity, invasive coronary angiography, cardiac stress testing
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