Rapid Decrease of Precipitating and Reaginic Antibodies in Dirofilaria Immitis-Infected Dogs Which Develop Severe Adverse Reactions Following Treatment with Diethylcarbamazine
Abstract
Dirofilaria immitis-infected dogs were treated with diethylcarbamazine. Measurement of the level of IgG precipitating antibody was carried out by counterimmunoelectrophoresis and that of IgE by passive cutaneous anaphylaxis in pre-treatment and post-treatment serum samples. In dogs showing severe to moderate adverse reactions to the drug there were pronounced decreases of both antibodies to a "metabolic" antigen prepared from the medium in which adult female worms had been incubated. These antibody levels did not decline in non-reacting dogs. Precipitating antibody levels to somatic antigens extracted from adult worms and microfilariae remained unaltered in both reactive and non-reactive animals.
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Massive antigen release after adulticide treatment correlates with increasing immunopathogenic responses.
“the subsequent massive antigen release after treatment correlates with increasing immunopathogenic responses (111).”
From Human and animal dirofilariasis: The emergence of a zoonotic mosaic (2012) · cites this paper as [111]
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Human and animal dirofilariasis: The emergence of a zoonotic mosaic
Simón, F., Siles-Lucas, M., Morchón, R., González-Miguel, J., Mellado, I., Carretón, E., & Montoya-Alonso, J. A. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.00012-12 · Cited by 834 · see citing works
“An increase in antibody responses after treatment with adulticides has been reported (416), and the subsequent massive antigen release after treatment correlates with increasing immunopathogenic responses (111).”
BackgroundMehta, K., Sindhu, R. K., Subrahmanyam, D., et al. (1980) · PubMed · Cited by 52 · see citing works
KNIGHT, D. H. (1987) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/s0195-5616(87)50012-2 · Cited by 39 · see citing works
Guerra-Caceres, J. G., Bryceson, A. D. M., Quakyi, I. A., et al. (1980) · Parasite Immunology · doi:10.1111/j.1365-3024.1980.tb00048.x · Cited by 27 · see citing works
Dennis, V. A., Klei, T. R., Miller, M. A., et al. (1992) · Veterinary Parasitology · doi:10.1016/0304-4017(92)90105-i · Cited by 20 · see citing works
Immunoglobulin interactions with surfaces of sheathed and unsheathed microfilariae
Hammerberg, B., Rikihisa, Y., & King, M. W. (1984) · Parasite Immunology · doi:10.1111/j.1365-3024.1984.tb00813.x · Cited by 20 · see citing works
Dirofilaria immitis: Diethylcarbamazine-induced anaphylactoid reactions in infected dogs
Hamilton, R. G., Wagner, E. M., April, M., et al. (1986) · Experimental Parasitology · doi:10.1016/0014-4894(86)90197-9 · Cited by 14 · see citing works
Atwell, R. B., & Boreham, P. F. L. (1983) · Journal of Small Animal Practice · doi:10.1111/j.1748-5827.1983.tb00357.x · Cited by 12 · see citing works
Immunopathology of Parasitic Diseases: A Conceptual Approach
Phillips, S. M., & Fox, E. G. (1984) · Springer eBooks · doi:10.1007/978-1-4684-4571-8_11 · Cited by 7 · see citing works
Carme, B., Richard-Lenoble, D., Amgar, A., et al. (1982) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(82)90133-x · Cited by 6 · see citing works
Studies on Alteration in Antibody Level of Filarious Host Following Diethylcarbamazine Treatment
Misra, S. B., Singh, D., & Chatterjee, R. K. (1988) · Institutional Repositories DataBase (IRDB)
- Authors
- Desowitz, R. S., Barnwell, J. W., Palumbo, N. E., Una, S. R., & Perri, S. F.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 1978-11
- Volume
- 27
- Issue
- 6
- Pages
- 1148-1151
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2340809971
- Cited by
- 11
- References
- 0
- Citations by year
- 2012: 1
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Keywords
- Dirofilaria immitis, canine heartworm disease, diethylcarbamazine, adverse drug reactions, precipitating antibodies, IgE, IgG, antibody levels, metabolic antigens, somatic antigens, microfilariae, antifilarial treatment
- MeSH terms
- Animals, Antibodies, Diethylcarbamazine, Dirofilaria immitis, Dirofilariasis, Dogs, Filarioidea
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