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Single Dose Mebendazole Therapy for Soil-Transmitted Nematodes
Abstract
Four hundred and fifty subjects were included in a study of the prevalence of soil-transmitted nematodes in Ujung Pandang, South-Sulawesi, Indonesia. Trichuriasis was the most prevalent infection (93.3%), followed by ascariasis (80.2%) and hookworm infection (19.5%). Among 156 subjects who were given 500 mg of mebendazole in a single dose, treatment resulted in cure rates of 93.4%, 77.6%, and 91.1%, and average egg-count reduction rates of 99.0%, 92.8%, and 98.3%, for ascariasis, trichuriasis, and hookworm infections, respectively. Mebendazole appeared to be equally effective against necatoriasis and ancylostomiasis. The drug was well tolerated and almost no side effects were observed. Single dose mebendazole treatment appears to be relatively inexpensive, convenient, and effective in mass treatment for the control of intestinal nematode infections, especially in highly infected communities.
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“On the other hand, a trial using 500 mg single dose of mebendazole was reported to be highly effective for ascariasis with 93.4% CR and 99.0% ERR [50].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [50]
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Efficacy of Current Drugs Against Soil-Transmitted Helminth Infections
Keiser, J., & Utzinger, J. (2008) · JAMA · doi:10.1001/jama.299.16.1937 · Cited by 801
Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286
Control strategies for human intestinal nematode infections.
Albonico, M., Crompton, D., & Savioli, L. (1999) · Advances in Parasitology · doi:10.1016/s0065-308x(08)60151-7 · Cited by 249
de Silva, N. D., Guyatt, H., & Bundy, D. A. P. (1997) · Drugs · doi:10.2165/00003495-199753050-00004 · Cited by 81
Albonico, M., Bickle, Q., Haji, H., Ramsan, M., Khatib, K. J., Montresor, A., Savioli, L., & Taylor, M. (2002) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(02)90352-4 · Cited by 60
Metadata
- Authors
- Abadi, K.
- Corresponding author
- Abadi, K.
- ORCID
- Abadi, K.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 1985-01-01
- Volume
- 34
- Issue
- 1
- Pages
- 129-133
- ISSN
- 0002-9637 (ISSN-L)
- 1476-1645
- OpenAlex
- W2337632612
- Cited by
- 22
- References
- 0
- Citations by year
- 2021: 1 · 2018: 1 · 2017: 1 · 2016: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- mebendazole, single-dose therapy, soil-transmitted nematodes, trichuriasis, ascariasis, hookworm infection, intestinal nematode infection, mass drug administration, cure rate, egg count reduction, drug tolerability, prevalence, Makassar
- MeSH terms
- Ascariasis, Benzimidazoles, Feces, Hookworm Infections, Humans, Mebendazole, Nematode Infections, Parasite Egg Count, Trichuriasis
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- CoChat. (2026). Citation check: Single Dose Mebendazole Therapy for Soil-Transmitted Nematodes. https://app.cochat.ai/papers/10.4269/ajtmh.1985.34.129
- The paper
- Abadi, K. (1985). Single Dose Mebendazole Therapy for Soil-Transmitted Nematodes. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.1985.34.129
