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Neuropsychiatric Side Effects after the use of Mefloquine
Abstract
This study describes neuropsychiatric side effects in patients after treatment with mefloquine. Reactions consisted mainly of seizures, acute psychoses, anxiety neurosis, and major disturbances of sleep-wake rhythm. Side effects occurred after both therapeutic and prophylactic intake and were graded from moderate to severe. In a risk analysis of neuropsychiatric side effects in Germany, it is estimated that one of 8,000 mefloquine users suffers from such reactions. The incidence calculation revealed that one of 215 therapeutic users had reactions, compared with one of 13,000 in the prophylaxis group, making the risk of neuropsychiatric reactions after mefloquine treatment 60 times higher than after prophylaxis. Therefore, certain limitations for malaria prophylaxis and treatment with mefloquine are recommended.
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Citations
Cited by
World Health Organization (2000) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(00)90300-6 · Cited by 1,085
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Foley, M. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00012-6 · Cited by 592
(2014) · Tropical Medicine & International Health · doi:10.1111/tmi.12313_2 · Cited by 543
Overbosch, D., Schilthuis, H., Bienzle, U., Behrens, R. H., Kain, K. C., Clarke, P. D., Toovey, S., Knobloch, J., Nothdurft, H. D., Shaw, D., et al. (2001) · Clinical Infectious Diseases · doi:10.1086/322694 · Cited by 256
Briand, V., Bottero, J., Noël, H., Masse, V., Cordel, H., Guerra, J., Kossou, H., Fayomi, B., Ayemonna, P., Fievet, N., et al. (2009) · The Journal of Infectious Diseases · doi:10.1086/605474 · Cited by 98
Metadata
- Authors
- Weinke, T., Trautmann, M., Held, T., Weber, G., Eichenlaub, D., Fleischer, K., Kern, W., & Pohle, H. D.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 1991-07
- Volume
- 45
- Issue
- 1
- Pages
- 86-91
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W1823594715
- Cited by
- 204
- References
- 0
- FWCI
- 20.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Neuropsychiatric Side Effects after the use of Mefloquine. https://app.cochat.ai/papers/10.4269/ajtmh.1991.45.86
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- Weinke, T., Trautmann, M., Held, T., Weber, G., Eichenlaub, D., Fleischer, K., Kern, W., & Pohle, H. D. (1991). Neuropsychiatric Side Effects after the use of Mefloquine. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.1991.45.86
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
