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Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers.
Abstract
Recent evidence suggest that resistance to praziquantel (PZQ) may be developing. This would not be surprising in countries like Egypt where the drug has been used aggressively for more that 10 years. The classic phenotype of drug resistance is a significant increase in the 50% effective dose value of isolates retrieved from patients not responding to the drug. In a previous publication, we reported that such phenotypes have been isolated from humans infected with Schistosoma mansoni. Since the action of PZQ may be dependent upon the drug and host factors, most notably the immune system, we analyzed the quantitative effects of PZQ on single worms that differed in their response to PZQ when maintained in mice. Our hypothesis was that the in vitro action of the drug would correlate with it in vivo action. We confirmed this hypothesis and conclude that the in vitro action of the drug is related to its in vivo action. Knowing this relationship will assist in our ability to detect or survey for the PZQ resistant phenotype in human populations.
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Citations
Cited by
Drug Resistance in Human Helminths: Current Situation and Lessons from Livestock
Geerts, S., & Gryseels, B. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.2.207 · Cited by 355
Marek, M., Kannan, S., Hauser, A.-T., Moraes Mourão, M., Caby, S., Cura, V., Stolfa, D. A., Schmidtkunz, K., Lancelot, J., Andrade, L., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003645 · Cited by 173
Anthelmintic resistance in human helminths: a review
Geerts, S., & Gryseels, B. (2001) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.2001.00774.x · Cited by 163
Heimburg, T., Chakrabarti, A., Lancelot, J., Marek, M., Melesina, J., Hauser, A.-T., Shaik, T. B., Duclaud, S., Robaa, D., Erdmann, F., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01478 · Cited by 124
Bayer, T., Chakrabarti, A., Lancelot, J., Shaik, T. B., Hausmann, K., Melesina, J., Schmidtkunz, K., Marek, M., Erdmann, F., Schmidt, M., et al. (2018) · ChemMedChem · doi:10.1002/cmdc.201800238 · Cited by 23
Metadata
- Authors
- Ismail, M., Botros, S., Metwally, A., William, S., Farghally, A., Tao, L. F., Day, T. A., & Bennett, J. L.
- Venue
- The American journal of tropical medicine and hygiene
- Published
- 1999-06
- Volume
- 60
- Issue
- 6
- Pages
- 932-935
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2187144093
- Cited by
- 495
- References
- 0
- FWCI
- 7.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers. https://app.cochat.ai/papers/10.4269/ajtmh.1999.60.932
- The paper
- Ismail, M., Botros, S., Metwally, A., William, S., Farghally, A., Tao, L. F., Day, T. A., & Bennett, J. L. (1999). Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers. The American journal of tropical medicine and hygiene. https://doi.org/10.4269/ajtmh.1999.60.932
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
