The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy.
Open accessAbstract
The safety of daily application of N, N-diethyl-m-toluamide (DEET) (1.7 g of DEET/day) in the second and third trimesters of pregnancy was assessed as part of a double-blind, randomized, therapeutic trial of insect repellents for the prevention of malaria in pregnancy (n = 897). No adverse neurologic, gastrointestinal, or dermatologic effects were observed for women who applied a median total dose of 214.2 g of DEET per pregnancy (range = 0-345.1 g). DEET crossed the placenta and was detected in 8% (95% confidence interval = 2.6-18.2) of cord blood samples from a randomly selected subgroup of DEET users (n = 50). No adverse effects on survival, growth, or development at birth, or at one year, were found. This is the first study to document the safety of DEET applied regularly in the second and third trimesters of pregnancy. The results suggest that the risk of DEET accumulating in the fetus is low and that DEET is safe to use in later pregnancy.
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Cites
Malaria during pregnancy in an area of unstable endemicity.
Nosten, F., ter Kuile, F., Maelankirri, L., Decludt, B., & White, N. J. (1991) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(91)90205-d · Cited by 294
Self-citationMcGready, R., Simpson, J. A., Htway, M., White, N. J., Nosten, F., & Lindsay, S. W. (2001) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(01)90137-3 · Cited by 44
Self-citationNeonatal neurological testing in resource-poor settings
McGready, R., Simpson, J., Panyavudhikrai, S., Loo, S., Mercuri, E., Haataja, L., Kolatat, T., Nosten, F., & Dubowitz, L. (2000) · Annals of Tropical Paediatrics · doi:10.1080/02724936.2000.11748154 · Cited by 37
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Cited by
Insect repellents: Historical perspectives and new developments
Katz, T. M., Miller, J. H., & Hebert, A. A. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.10.005 · Cited by 455
Malaria in pregnancy in the Asia-Pacific region
Rijken, M. J., McGready, R., Boel, M. E., Poespoprodjo, R., Singh, N., Syafruddin, D., Rogerson, S., & Nosten, F. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70315-2 · Cited by 181
Self-citationReducing the burden of malaria in pregnancy by preventive strategies
Menéndez, C., D'Alessandro, U., & ter Kuile, F. O. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70024-5 · Cited by 188
Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes
Panchaud, A., Stojanov, M., Ammerdorffer, A., Vouga, M., & Baud, D. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-16 · Cited by 171
Prevention of malaria in pregnancy
Desai, M., Hill, J., Fernandes, S., Walker, P., Pell, C., Gutman, J., Kayentao, K., Gonzalez, R., Webster, J., Greenwood, B., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30064-1 · Cited by 153
Metadata
- Authors
- McGready, R., Hamilton, K. A., Simpson, J. A., Cho, T., Luxemburger, C., Edwards, R., Looareesuwan, S., White, N. J., Nosten, F., & Lindsay, S. W.
- Venue
- The American journal of tropical medicine and hygiene
- Published
- 2001-10
- Volume
- 65
- Issue
- 4
- Pages
- 285-289
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2149746703
- Cited by
- 195
- References
- 3
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy. https://app.cochat.ai/papers/10.4269/ajtmh.2001.65.285
- The paper
- McGready, R., Hamilton, K. A., Simpson, J. A., Cho, T., Luxemburger, C., Edwards, R., Looareesuwan, S., White, N. J., Nosten, F., & Lindsay, S. W. (2001). Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy. The American journal of tropical medicine and hygiene. https://doi.org/10.4269/ajtmh.2001.65.285
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
